Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner

Balleine BW, O’Doherty JP. Human and rodent homologies in action control: corticostriatal determinants of goal-directed and habitual action. Neuropsychopharmacology. 2010;35:48–69.

Article  PubMed  PubMed Central  Google Scholar 

Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, et al. Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcohol Clin Exp Res. 2011;35:1739–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gass JT, Glen WB, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, et al. Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood. Neuropsychopharmacology. 2014;39:2570–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ragozzino ME, Ragozzino KE, Mizumori SJ, Kesner RP. Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning. Behav Neurosci. 2002;116:105–15.

Article  PubMed  PubMed Central  Google Scholar 

Abrahao KP, Salinas AG, Lovinger DM. Alcohol and the brain: neuronal molecular targets, synapses, and circuits. Neuron. 2017;96:1223–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DePoy L, Daut R, Brigman JL, MacPherson K, Crowley N, Gunduz-Cinar O, et al. Chronic alcohol produces neuroadaptations to prime dorsal striatal learning. Proc Natl Acad Sci USA. 2013;110:14783–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imbriani P, Sciamanna G, El Atiallah I, Cerri S, Hess EJ, Pisani A. Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia. FEBS J. 2022;289:5834–49.

Article  CAS  PubMed  Google Scholar 

Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35:217–38.

Article  PubMed  Google Scholar 

Zachry JE, Nolan SO, Brady LJ, Kelly SJ, Siciliano CA, Calipari ES. Sex differences in dopamine release regulation in the striatum. Neuropsychopharmacology. 2021;46:491–99.

Article  PubMed  Google Scholar 

Yin HH, Park BS, Adermark L, Lovinger DM. Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum. Eur J Neurosci. 2007;25:3226–32.

Article  PubMed  Google Scholar 

Yin HH, Knowlton BJ. Contributions of striatal subregions to place and response learning. Learn Mem. 2004;11:459–63.

Article  PubMed  PubMed Central  Google Scholar 

Yin HH, Knowlton BJ. The role of the basal ganglia in habit formation. Nat Rev Neurosci. 2006;7:464–76.

Article  CAS  PubMed  Google Scholar 

Yin HH, Ostlund SB, Knowlton BJ, Balleine BW. The role of the dorsomedial striatum in instrumental conditioning. Eur J Neurosci. 2005;22:513–23.

Article  PubMed  Google Scholar 

Huang Z, Chen R, Ho M, Xie X, Gangal H, Wang X, et al. Dynamic responses of striatal cholinergic interneurons control behavioral flexibility. Sci Adv. 2024;10:eadn2446.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma T, Huang Z, Xie X, Cheng Y, Zhuang X, Childs MJ, et al. Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility. J Clin Invest. 2022;132;e154969.

Barker JM, Taylor JR. Habitual alcohol seeking: modeling the transition from casual drinking to addiction. Neurosci Biobehav Rev. 2014;47:281–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ostlund SB, Maidment NT, Balleine BW. Alcohol-paired contextual cues produce an immediate and selective loss of goal-directed action in rats. Front Integr Neurosci. 2010;4:19.

Wise RA, Robble MA. Dopamine and addiction. Annu Rev Psychol. 2020;71:79–106.

Article  PubMed  Google Scholar 

Siciliano CA, Karkhanis AN, Holleran KM, Melchior JR, Jones SR. Cross-species alterations in synaptic dopamine regulation after chronic alcohol exposure. Handb Exp Pharm. 2018;248:213–38.

Article  Google Scholar 

Charlet K, Beck A, Heinz A. The dopamine system in mediating alcohol effects in humans. In: Sommer WH, Spanagel R, editors. Behavioral neurobiology of alcohol addiction. Berlin, Heidelberg: Springer Berlin Heidelberg; 2013. pp. 461–88.

Barrios N, Riordan W, Garcia-Rivas V, Peltier MR, Roberts W, Verplaetse TL, et al. Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. Biol Sex Differ. 2025;16:24.

Article  PubMed  PubMed Central  Google Scholar 

Becker JB, Hu M. Sex differences in drug abuse. Front Neuroendocrinol. 2008;29:36–47.

Article  CAS  PubMed  Google Scholar 

Salinas AG, Mateo Y, Carlson VCC, Stinnett GS, Luo G, Seasholtz AF, et al. Long-term alcohol consumption alters dorsal striatal dopamine release and regulation by D2 dopamine receptors in rhesus macaques. Neuropsychopharmacology. 2021;46:1432–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berke JD. What does dopamine mean? Nat Neurosci. 2018;21:787–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greenstreet F, Vergara HM, Johansson Y, Pati S, Schwarz L, Lenzi SC, et al. Dopaminergic action prediction errors serve as a value-free teaching signal. Nature. 2025;643:1333–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kutlu MG, Zachry JE, Melugin PR, Cajigas SA, Chevee MF, Kelly SJ, et al. Dopamine release in the nucleus accumbens core signals perceived saliency. Curr Biol. 2021;31:4748–61.e8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kutlu MG, Zachry JE, Melugin PR, Tat J, Cajigas S, Isiktas AU, et al. Dopamine signaling in the nucleus accumbens core mediates latent inhibition. Nat Neurosci. 2022;25:1071–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeong H, Taylor A, Floeder JR, Lohmann M, Mihalas S, Wu B, et al. Mesolimbic dopamine release conveys causal associations. Science. 2022;378:eabq6740.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takahashi YK, Stalnaker TA, Mueller LE, Harootonian SK, Langdon AJ, Schoenbaum G. Dopaminergic prediction errors in the ventral tegmental area reflect a multithreaded predictive model. Nat Neurosci. 2023;26:830–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharpe MJ, Chang CY, Liu MA, Batchelor HM, Mueller LE, Jones JL, et al. Dopamine transients are sufficient and necessary for acquisition of model-based associations. Nat Neurosci. 2017;20:735–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langdon AJ, Sharpe MJ, Schoenbaum G, Niv Y. Model-based predictions for dopamine. Curr Opin Neurobiol. 2018;49:1–7.

Article  CAS  PubMed  Google Scholar 

Niv Y, Daw ND, Joel D, Dayan P. Tonic dopamine: opportunity costs and the control of response vigor. Psychopharmacology. 2007;191:507–20.

Article  CAS  PubMed  Google Scholar 

da Silva JA, Tecuapetla F, Paixão V, Costa RM. Dopamine neuron activity before action initiation gates and invigorates future movements. Nature. 2018;554:244–48.

Article  PubMed 

Comments (0)

No login
gif