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Transcriptomic analysis suggests ferroptosis as a potential mechanism of fipronil-induced cytotoxicity in human glioblastoma cells
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18-β-Glycyrrhetinic-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles downregulate the expression LPS-induced proteins mediating tissue remodelling in vitro
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1,25-Dihydroxyvitamin D3 attenuates TGF-β1-induced airway remodeling in asthma by inhibiting IL-33 mediated by the ERK1/2 signaling pathway
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SiO2 dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway
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Assay integration for reproducible toxicity testing of particulate matter in a single well: cytotoxicity, oxidative stress, inflammatory response, and mRNA profiling
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In vitro effects of polystyrene microplastics exposure on adipose tissue dysfunction
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ESTIV 2024: The application of new approach methodologies (NAMs) in drug discovery and drug and chemical safety assessment
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Corrigendum to “Validation of a new 3D epidermis model for the SENS-IS assay to evaluate skin sensitization potency of chemicals” [Toxicol In Vitro, 106 (2025) 106039]
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Antileishmanial activity, cytotoxicity, and immunomodulatory effects of a naphthoquinone derivative
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Sublethal concentrations of PFOS and PFDA differentially impact brood size and gene expression in Caenorhabditis elegans
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Context-dependent effects of high-frequency pulsed electromagnetic fields on cytokine responses in human THP-1 monocytes in vitro
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Carboxylesterase 2 as a potential molecular target for long-chain perfluoroalkyl carboxylic acids.
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Harnessing human colonoid-derived monolayers as an in vitro platform for investigating accumulation, toxicity, and pharmacodynamics of small molecules
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In-vitro study and in-vivo zebrafish model to minimize the toxic effects of implant (CoCrMo particles) by antioxidants
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A human-relevant epithelial–fibroblast co-culture platform for integrated analysis of PHMG-HCl–induced pulmonary fibrogenic responses
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Comparison of two human cell-based in vitro eye hazard assessment methods: the cytotoxicity test for evaluation of eye irritation (CEI) and the OECD 492B method
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Effects of quantum dots on integrin expression and cellular responses in DU145 prostate cancer cells
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Current perspectives on the in vitro cytotoxic effects of tebuconazole, imidacloprid, and microplastics: A comprehensive review
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Testing chemicals for CYP19 inhibition: Comparison of a modified H295R steroidogenesis assay to a commercial fluorometric enzyme inhibition kit
Aromatase (CYP19A1) is a key enzyme that converts androgens to estrogens. Given its central role in estrogen biosynthesis,...
Lupeol-loaded PLGA particles conserve anti-topoisomerase activity and decrease the cytotoxicity of lupeol
Triterpenes and steroids constitute a broad class of compounds, with approximately 4000 structures derived from mevalonic ...
The neuroprotective role of chlorogenic acid and Fisetin in differentiated neuronal cell line-SHSY5Y against amyloid-β-induced neurotoxicity
Autophagy is a conserved catabolic process that helps the body to replenish nutrients under starving conditions, is crucia...
Polystyrene nanoplastic co-exposed to BPA and BPS induces cytotoxicity, genotoxicity, and alters ROS production in HepG2 cells
Plastics are commonly used in food and beverage packaging, pharmaceuticals, cosmetics, cleaning, and chemical products (Ga...
Cytotoxic effects of a LED/UV nail polish dryer in human keratinocytes
Nail polish dryers are radiation-emitting devices designed to dry and cure nail polishes. These devices primarily emit rad...
Computational and spectrofluorimetric validation on glyphosate interactions with zebrafish (Danio rerio) acetylcholinesterase: Mechanistic and ecotoxicological implications
Herbicides are the most widely used agrochemicals worldwide, accounting for approximately 47.5 % of the total utilized in ...
Cytotoxic and immunotoxic profile of HgCl2 involves alterations in purinergic signaling through the P2X7/NLRP3/CASP-1/IL-1β pathway: An in vitro study using human blood immune cells
Mercury (Hg), a chemical pollutant, poses a significant risk to human health globally. It is considered a hazardous substa...
Comparison of the behavior of human lung epithelial cell lines cultured at the air-liquid interface and assessment of their responses after benzo(a)pyrene exposure
The biological effects of air pollution are still not well known, due to its complex mixture of particulate and gaseous co...
Evaluating cannabidiol-induced liver injury with and without valproate using a three-dimensional human hepatocyte spheroid model
Cannabidiol (CBD) and valproate (VPA) are anti-epileptic medications commonly co-prescribed to treat seizures due to Lenno...
Inhibitory potential of phytochemicals on species-specific breast cancer resistance protein transport activity
The use of herbal alternatives in modern agriculture and healthcare offers a sustainable approach to animal and human heal...
Transcriptomic points of departure for 6PPD-Quinone derived from human Caco-2 and HepG2 cells
N-(1,3-Dimethyl butyl)-N′-phenyl-phenylenediamine-quinone (6ppd-quinone) is of emerging concern due to its widespread pres...
Inter-laboratory validation study of an in vitro glucocorticoid receptor transactivation assay for testing potential endocrine disrupting chemicals
The glucocorticoid receptor (GR) belongs to the family of steroid receptors (SRs). These receptors regulate a vast selecti...
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