Bitter Bean () Aqueous Extract: A Potential Natural Compound Agent Against Mammary Carcinoma in BALB/c Mice

Aisha A, Abu-Salah KM, Alrokayan SA (2012) Evaluation of antiangiogenic and antioxidant properties of Parkia speciosa Hassk extracts. Pak J Pharm Sci 25:7–14

CAS  PubMed  Google Scholar 

Akram M, Iqbal M, Daniyal M, Khan AU (2017) Awareness and current knowledge of breast cancer. Biol Res 50:33. https://doi.org/10.1186/s40659-017-0140-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alam MM, Naeem M, Masroor MAK, Uddin M (2017) Vincristine and vinblastine anticancer catharanthus alkaloids: pharmacological applications and strategies for yield improvement, in: Catharanthus roseus: Current Research and Future Prospects. Springer International Publishing, pp. 277–307. https://doi.org/10.1007/978-3-319-51620-2_11

Alipanah H, Reza Bigdeli M, Esmaeili MA (2018) Inhibitory effect of Viola odorata extract on tumor growth and metastasis in 4T1 breast cancer model. Iran J Pharm Res 17:276–291

CAS  PubMed  PubMed Central  Google Scholar 

Aneja S, Vats M, Aggarwal S, Sardana S (2013) Phytochemistry and hepatoprotective activity of aqueous extract of Amaranthus tricolor Linn. roots. J Ayurveda Integr Med 4:211–215. https://doi.org/10.4103/0975-9476.123693

Article  PubMed  PubMed Central  Google Scholar 

Asikin Y, Kusumiyati Shikanai T, Wada K (2018) Volatile aroma components and MS-based electronic nose profiles of dogfruit (Pithecellobium jiringa) and stink bean (Parkia speciosa). J Adv Res 9:79–85. https://doi.org/10.1016/j.jare.2017.11.003

Article  CAS  PubMed  Google Scholar 

Azemi AK, Nordin ML, Hambali KA, Noralidin NA, Mokhtar SS, Rasool AHG (2022) Phytochemical contents and pharmacological potential of Parkia speciosa Hassk. for diabetic vasculopathy: a review. Antioxidants 11:431. https://doi.org/10.3390/antiox11020431

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balaji K, Nedumaran SA, Devi T, Sikarwar MS, Fuloria S (2015) Phytochemical analysis and in vitro antioxidant activity of Parkia speciosa. Intl J Green Pharm 9. https://doi.org/10.22377/ijgp.v9i4.587

Banerjee SK, Maulik M, Manchanda SC, Dinda AK, Das TK, Maulik SK (2001) Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food Chem Toxicol 39:793–797. https://doi.org/10.1016/S0278-6915(01)00018-7

Article  CAS  PubMed  Google Scholar 

Chauhan P, Yadav R, Kaushal V, Beniwal P (2016) Evaluation of serum biochemical profile of breast cancer patients. Int J Med Res Health Sci 5:1–7

CAS  Google Scholar 

Chen J, Wang Z, Lu Y, Dalton JT, Miller DD, Li W (2008) Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma. Bioorg Med Chem Lett 18:3183–3187. https://doi.org/10.1016/j.bmcl.2008.04.073

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Arcy MS (2019) Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int 43:582–592. https://doi.org/10.1002/cbin.11137

Article  PubMed  Google Scholar 

De Souza Rosa L, Jordão NA, Da Costa Pereira Soares N, De Mesquita JF, Monteiro M, Teodoro AJ (2018) Pharmacokinetic, antiproliferative and apoptotic effects of phenolic acids in human colon adenocarcinoma cells using in vitro and in silico approaches. Molecules 23:2569. https://doi.org/10.3390/molecules23102569

Article  CAS  Google Scholar 

Fassl A, Brain C, Abu-Remaileh M, Stukan I, Butter D, Stepien P, Feit AS, Bergholz J, Michowski W, Otto T, Sheng Q, Loo A, Michael W, Tiedt R, Deangelis C, Schiff R, Jiang B, Jovanovic B, Nowak K, Ericsson M, Cameron M, Gray N, Dillon D, Zhao JJ, Sabatini DM, Jeselsohn R, Brown M, Polyak K, Sicinski P (2020) Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Sci Adv 6:eabb2210. https://doi.org/10.1126/sciadv.abb2210

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fotsing YSF, Kezetas Jean Jules B, El-Saber Batiha G, Ali I, Ndjakou Bruno L (2022) Extraction of bioactive compounds from medicinal plants and herbs, in: natural medicinal plants. IntechOpen. https://doi.org/10.5772/intechopen.98602

Fridlender M, Kapulnik Y, Koltai H (2015) Plant derived substances with anti-cancer activity: from folklore to practice. Front Plant Sci 6:799. https://doi.org/10.3389/fpls.2015.00799

Article  PubMed  PubMed Central  Google Scholar 

Hausman DM (2019) What is cancer? Perspect Biol Med 62:778–784. https://doi.org/10.1353/pbm.2019.0046

Article  PubMed  Google Scholar 

Holliday DL, Speirs V (2011) Choosing the right cell line for breast cancer research. Breast Cancer Res 13:215. https://doi.org/10.1186/bcr2889

Kang DY, Bae SW, Jang K-J (2025) Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells. Mol Med Rep 31:151. https://doi.org/10.3892/mmr.2025.13516

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khangembam VC, Srivastava SK, Leishangthem GD, Kataria M, Thakuria D (2018) Evaluation of apoptosis inducing ability of Parkia javanica seed extract in cancer cells. Indian J Pharm Sci 80:1069–1077. https://doi.org/10.4172/PHARMACEUTICAL-SCIENCES.1000457

Article  CAS  Google Scholar 

Lin X, Wang G, Liu P, Han L, Wang T, Chen K, Gao Y (2021) Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation. Exp Ther Med 21:638. https://doi.org/10.3892/etm.2021.10070

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Chen P, Zhou M, Wang T, Fang S, Shang X, Fu X (2018) Geographic variation in the chemical composition and antioxidant properties of phenolic compounds from Cyclocarya paliurus (batal) iljinskaja leaves. Molecules 23:2440. https://doi.org/10.3390/molecules23102440

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo KW, Yue GGL, Ko CH, Lee JKM, Gao S, Li LF, Li G, Fung KP, Leung PC, Lau CBS (2014) In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma. Phytomedicine 21:1078–1087. https://doi.org/10.1016/j.phymed.2014.04.020

Article  PubMed  Google Scholar 

Luo H, Zhao L, Li Y, Xia B, Lin Y, Xie J, Wu P, Liao D, Zhang Z, Lin L (2022) An in vivo and in vitro assessment of the anti-breast cancer activity of crude extract and fractions from Prunella vulgaris L. Heliyon 8:e11183. https://doi.org/10.1016/j.heliyon.2022.e11183

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mansur NS, Bakar NAA, Omar M (2022) A preliminary study on young consumer preferences of herbs on daily consumption usage. Med Plants Intl J Phytomed Related Industries 14:484–491. https://doi.org/10.5958/0975-6892.2022.00053.3

Article  Google Scholar 

Noralidin NA, Rajoodorai VK, Hambali KA, Hanif Reduan MF, Mohd Rajdi NZI, Shaharulnizim N, Abdul Hamid FF, Jasni Sabri JS, Ali Al Sultan II, Shaari R, Luqman Nordin M (2022) Cytotoxicity and acute oral toxicity effects of Parkia speciosa seeds extract in C57bl/6 mice. Biomed Pharmacol J 15:123–135. https://doi.org/10.13005/bpj/2348

Article  CAS  Google Scholar 

Nordin ML, Abdul Kadir A, Zakaria ZA, Abdullah R, Abdullah MNH (2018) In vitro investigation of cytotoxic and antioxidative activities of Ardisia crispa against breast cancer cell lines, MCF-7 and MDA-MB-231. BMC Complement Altern Med 18:87. https://doi.org/10.1186/s12906-018-2153-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reihani SFS, Azhar ME (2012) Antioxidant activity and total phenolic content in aqueous extract of selected traditional Malay salads (Ulam). Int Food Res J 19:1439–1444

CAS  Google Scholar 

Şerban C (2015) The story of MCF-7 breast cancer cell line: 40 years of experience in research. Anticancer Res 35:3147–3154

Google Scholar 

Sharma T, Pandey B, Shrestha BK, Koju GM, Thusa R, Karki N (2020) Phytochemical screening of medicinal plants and study of the effect of phytoconstituents in seed germination. Tribhuvan Univ J 35:1–11. https://doi.org/10.3126/tuj.v35i2.36183

Article  Google Scholar 

Singh N, Patel K, Sahoo SK, Kumar R (2018) Human nitric oxide biomarker as potential NO donor in conjunction with superparamagnetic iron oxide @ gold core shell nanoparticles for cancer therapeutics. Colloids Surf B Biointerfaces 163:246–256. https://doi.org/10.1016/j.colsurfb.2017.12.052

Article  CAS  PubMed  Google Scholar 

Siow HL, Gan CY (2013) Extraction of antioxidative and antihypertensive bioactive peptides from Parkia speciosa seeds. Food Chem 141:3435–3442. https://doi.org/10.1016/j.foodchem.2013.06.030

Article  CAS  PubMed 

Comments (0)

No login
gif