World Health Organization. Climate change and noncommunicable diseases: connections. https://www.who.int/news/item/02-11-2023-climate-change-and-noncommunicable-diseases-connections.
World Health Organization. Climate change and health: Draft Global Action Plan on Climate Change and Health. https://apps.who.int/gb/ebwha/pdf_files/WHA78/A78_4Add2-en.pdf (2025).
Global Initiative For Asthma. Global strategy for asthma management and prevention. https://ginasthma.org/ (2025).
Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. https://goldcopd.org (2026).
Halpin, D. M. G. et al. Addressing the global challenges of COPD and asthma: a shared vision from the global initiative for chronic obstructive pulmonary disease (GOLD) and the global initiative for asthma (GINA). Eur. Respir. J. 67, 2502244 (2025).
Weinmayr, G., Romeo, E., De Sario, M., Weiland, S. K. & Forastiere, F. Short-term effects of PM10 and NO2 on respiratory health among children with asthma or asthma-like symptoms: A systematic review and meta-analysis. Environ. Health Perspect. 118, 449–457 (2010).
Dominski, F. H. et al. Effects of air pollution on health: a mapping review of systematic reviews and meta-analyses. Environ. Res.; 201, 111487 (2021).
Manisalidis, I., Stavropoulou, E., Stavropoulos, A. & Bezirtzoglou, E. Environmental and health impacts of air pollution: a review. Front. Public. Heal. 8, 505570 (2020).
Hoek, G. et al. Long-term air pollution exposure and cardio- respiratory mortality: a review. Environ. Heal. 12, 43 (2013).
United Nations. The impact of climate change on the rights of people in vulnerable situations. https://www.ohchr.org/en/climate-change/impact-climate-change-rights-people-vulnerable-situations.
European Commission. Air quality. https://environment.ec.europa.eu/topics/air/air-quality_en.
Li, S. et al. Ambient temperature and lung function in children with asthma in Australia. Eur. Respir. J. 43, 1059–1066 (2013).
Royé, D. et al. Temperature-related effects on respiratory medical prescriptions in Spain. Environ. Res. 202, 111695 (2021).
Han, A. et al. Asthma triggered by extreme temperatures: From epidemiological evidence to biological plausibility. Environ. Res. 216, 114489, https://doi.org/10.1016/J.ENVRES.2022.114489 (2023).
Tseng, C. M. et al. The effect of cold temperature on increased exacerbation of chronic obstructive pulmonary disease: a nationwide study. PLoS One 8, e57066, https://doi.org/10.1371/JOURNAL.PONE.0057066 (2013).
Gronlund, C. J., Zanobetti, A., Schwartz, J. D., Wellenius, G. A. & O’Neill, M. S. Heat, heat waves, and hospital admissions among the elderly in the United States, 1992-2006. Environ. Health Perspect. 122, 1187–1192 (2014).
Scheerens, C. et al. The impact of personal and outdoor temperature exposure during cold and warm seasons on lung function and respiratory symptoms in COPD. ERJ Open. Res. 8, 00574–02021, https://doi.org/10.1183/23120541.00574-2021 (2022).
Mekhuri, S., Quach, S., Barakat, C., Sun, W. & Nonoyama, M. L. A cross-sectional survey on the effects of ambient temperature and humidity on health outcomes in individuals with chronic respiratory disease. Can. J. Respir. Ther.; 59, 256–269 (2023).
Iñiguez, C., Royé, D. & Tobías, A. Contrasting patterns of temperature related mortality and hospitalization by cardiovascular and respiratory diseases in 52 Spanish cities. Environ. Res. 192, 110191 (2021).
Cheng, J. et al. Cardiorespiratory effects of heatwaves: A systematic review and meta-analysis of global epidemiological evidence. Environ. Res.; 177, 108610 (2019).
Zanobetti, A., O’Neill, M. S., Gronlund, C. J. & Schwartz, J. D. Summer temperature variability and long-term survival among elderly people with chronic disease. Proc. Natl. Acad. Sci. USA. 109, 6608–6613 (2012).
Rau, A. et al. Heat and cold wave-related mortality risk among united states veterans with chronic obstructive pulmonary disease: a case-crossover study. Environ. Health Perspect. 132, 27004 (2024).
Yu, K. et al. Association of non-optimum temperature, heatwaves and cold spells with chronic obstructive pulmonary disease mortality: A nationwide time-stratified case-crossover study. Ecotoxicol. Environ. Saf.; 302, 118760 (2025).
Baccini, M. et al. Heat effects on mortality in 15 European cities. Epidemiology 19, 711–719 (2008).
Tran, H. M., Chuang, T. W., Chuang, H. C. & Tsai, F. J. Climate change and mortality rates of COPD and asthma: A global analysis from 2000 to 2018. Environ. Res.; 233, 116448 (2023).
Tran, H. M. et al. Extreme temperature increases the risk of COPD morbimortality: a systematic review and meta-analysis. Sci. Total. Environ.; 958, 178087 (2025).
Rai, M. et al. Temporal variation in the association between temperature and cause-specific mortality in 15 German cities. Environ. Res.; 229, 115668 (2023).
Rau, A. et al. Comorbidities, tobacco exposure, and geography: Added risk factors of heat and cold wave–related mortality among U.S. veterans with chronic obstructive pulmonary disease. Ann. Am. Thorac. Soc. 22, 200–207 (2024).
Lung, S. C. C., Yeh, J. C. J., Hwang, J. S. & Chen, L. S. Diurnal temperature range and cardiopulmonary health in Taiwan: Evaluating impacts, thresholds, and vulnerable groups. Environ. Res. 263, 120083 (2024).
Anderson, G. B. et al. Heat-related emergency hospitalizations for respiratory diseases in the Medicare population. Am. J. Respir. Crit. Care Med. 187, 1098–1103 (2013).
Michelozzi, P. et al. High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities. Am. J. Respir. Crit. Care Med. 179, 383–389 (2009).
Konstantinoudis, G. et al. Ambient heat exposure and COPD hospitalisations in England: a nationwide case-crossover study during 2007-2018. Thorax 77, 1098–1104 (2022).
Lin, S. et al. Extreme high temperatures and hospital admissions for respiratory and cardiovascular diseases. Epidemiology 20, 738–746 (2009).
Hayes, D., Collins, P. B., Khosravi, M., Lin, R.-L. & Lee, L.-Y. Bronchoconstriction triggered by breathing hot humid air in patients with asthma. Am. J. Respir. Crit. Care Med. 185, 1190–1196 (2012).
Mu, Z. et al. Synergistic effects of temperature and humidity on the symptoms of COPD patients. Int. J. Biometeorol. 61, 1919–1925 (2017).
Rau, A. et al. Compound drought and heatwave extreme weather events: Mortality risk in individuals with chronic respiratory disease. Environ. Epidemiol. 9, e389 (2025).
Liu, J. et al. Heat exposure and cardiovascular health outcomes: a systematic review and meta-analysis. Lancet. Planet. Heal.; 6, e484–e495 (2022).
Centers for Disease Control and Prevention. FluView. https://www.cdc.gov/fluview/.
PoshtMashhadi, A., Ijadi Maghsoodi, A. & Wood, L. C. The impact of extreme temperatures on emergency department visits: a systematic review of heatwaves, cold waves, and daily temperature variations. Sci. Total. Environ. 970, 178869 (2025).
Hansel, N. N., McCormack, M. C. & Kim, V. The effects of air pollution and temperature on COPD. COPD 13, 372–379 (2016).
Davie, G. S., Baker, M. G., Hales, S. & Carlin, J. B. Trends and determinants of excess winter mortality in New Zealand: 1980 to 2000. BMC Public. Health 7, 263. https://doi.org/10.1186/1471-2458-7-263 (2007).
Schwartz, J. Who is sensitive to extremes of temperature?: a case-only analysis. Epidemiology 16, 67–72 (2005).
Burkart, K. G. et al. Estimating the cause-specific relative risks of non-optimal temperature on daily mortality: a two-part modelling approach applied to the global burden of disease study. Lancet 398, 685–697 (2021).
McCormack, M. C. et al. Colder temperature is associated with increased COPD morbidity. Eur. Respir. J. 49, 1601501 (2017).
Tamerius, J. D. et al. Socioeconomic and outdoor meteorological determinants of indoor temperature and humidity in New York City dwellings. Weather. Clim. Soc.; 5, 168–179 (2013).
McCormack, M. C. et al. Respiratory effects of indoor heat and the interaction with air pollution in chronic obstructive pulmonary disease. Ann. Am. Thorac. Soc.; 13, 2125–2131 (2016).
Heslin, K. C. et al. Effects of hurricanes on emergency department utilization: an analysis across 7 US storms. Disaster Med. Public. Health Prep. 15, 762–769 (2021).
Lawrence, W. R. et al. After the storm: Short-term and long-term health effects following superstorm sandy among the elderly. Disaster Med. Public. Health Prep. 13, 28–32 (2019).
Chowdhury, M. A. B. et al. Health impact of Hurricanes Irma and Maria on St Thomas and St John, US Virgin Islands, 2017–2018. Am. J. Public. Health 109, 1725–1732 (2019).
Glick, S., Gehrig, R. & Eeftens, M. Multi-decade changes in pollen season onset, duration, and intensity: a concern for public health?. Sci. Total. Environ.; 781, 146382, https://doi.org/10.1016/J.SCITOTENV.2021.146382 (2021).
Anderegg, W. R. L. et al. Anthropogenic climate change is worsening North American pollen seasons. Proc. Natl. Acad. Sci. USA. 118, e2013284118 (2021).
Zhang, Y. & Steiner, A. L. Projected climate-driven changes in pollen emission season length and magnitude over the continental United States. Nat. Commun. 13, 1234 (2022).
Rao, C. Y. et al. Characterization of airborne molds, endotoxins, and glucans in homes in New Orleans after Hurricanes Katrina and Rita. Appl. Environ. Microbiol. 73, 1630–1634 (2007).
Verhoeff, A. P. & Burge, H. A. Health risk assessment of fungi in home environments. Ann. Allergy. Asthma Immunol.; 78, 544–556 (1997).
Gent, J. F. et al. Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. Environ. Health Perspect. 110, A781–A786, https://doi.org/10.1289/EHP.021100781 (2002).
Kearsley J. Regulation 28 report to prevent future deaths. https://www.judiciary.uk/wp-content/uploads/2022/11/Awaab-Ishak-Prevention-of-future-deaths-report-2022-0365_Published.pdf6.
Liu, A., Sheng, W. & Tang, X. Atmospheric pollen concentrations and chronic obstructive pulmonary disease (COPD) patients visits in Beijing: time series analysis using a generalized additive model. Sci. Rep. 14, 3462 (2024).
Tiew, P. Y. et al. Environmental fungal sensitisation associates with poorer clinical outcomes in COPD. Eur. Respir. J. 56, 2000418, https://doi.org/10.1183/13993003.00418-2020 (2020).
Thien, F., Davies, J. M., Douglass, J. A. & Hew, M. Thunderstorm asthma: current perspectives and emerging trends. J. Allergy Clin. Immunol. Pract. 13, 1273–1280, https://doi.org/10.1016/J.JAIP.2025.04.001 (2025).
Diver, S. et al. Under the weather: an epidemic thunderstorm asthma event in Leicester, June 2023. BMJ Open. Respir. Res.; 12, e002588 (2025).
He, Y., Liu, W. J., Jia, N., Richardson, S. & Huang, C. Viral respiratory infections in a rapidly changing climate: the need to prepare for the next pandemic. eBioMedicine 93, 104593 (2023).
Fanelli, A. et al. Assessing the risk of diseases with epidemic and pandemic potential in a changing world. Sci. Adv. 11, eadw6363 (2025).
Petridou, C. & Belfield, A. Impact of climate change and infectious diseases: Implications for healthcare providers in the UK. Futur. Healthc. J.; 12, 100239 (2025).
Hoaas, H. et al. Seasonal variations in objectively assessed physical activity among people with COPD in two Nordic countries and Australia: a cross-sectional study. Int. J. Chron. Obstruct. Pulmon. Dis. 14, 1219–1228 (2019).
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