Wee WB, Kinghorn B, Davis SD, Ferkol TW, Shapiro AJ (2024) Primary ciliary dyskinesia. Pediatrics. https://doi.org/10.1542/peds.2023-063064
Wijers CD, Chmiel JF, Gaston BM (2017) Bacterial infections in patients with primary ciliary dyskinesia: comparison with cystic fibrosis. Chron Respir Dis 14(4):392–406
Article PubMed PubMed Central Google Scholar
Pereira R, Barbosa T, Cardoso AL, Sá R, Sousa M (2023) Cystic fibrosis and primary ciliary dyskinesia: similarities and differences. Respir Med 209:107169
Flume PA, Chalmers JD, Olivier KN (2018) Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity. Lancet 392(10150):880–890
Article PubMed PubMed Central Google Scholar
Keir HR, Chalmers JD (2021) Pathophysiology of bronchiectasis. Semin Respir Crit Care Med 42(4):499–512
Bush A, Payne D, Pike S, Jenkins G, Henke MO, Rubin BK (2006) Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis. Chest 129(1):118–123
Sagel SD, Kupfer O, Wagner BD, Davis SD, Dell SD, Ferkol TW et al (2023) Airway inflammation in children with primary ciliary dyskinesia. Ann Am Thorac Soc 20(1):67–74
Article PubMed PubMed Central Google Scholar
Ratjen F, Waters V, Klingel M, McDonald N, Dell S, Leahy TR et al (2016) Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia. Eur Respir J 47(3):829–836
Article CAS PubMed Google Scholar
Blanter M, Cockx M, Wittebols L, Abouelasrar Salama S, De Bondt M, Berghmans N et al (2022) Sputum from patients with primary ciliary dyskinesia contains high numbers of dysfunctional neutrophils and inhibits efferocytosis. Respir Res 23(1):359
Article CAS PubMed PubMed Central Google Scholar
Aegerter H, Lambrecht BN, Jakubzick CV (2022) Biology of lung macrophages in health and disease. Immunity 55(9):1564–1580
Article CAS PubMed PubMed Central Google Scholar
Arango Duque G, Descoteaux A (2014) Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol 5:491
Article PubMed PubMed Central Google Scholar
Martinez FO, Gordon S (2014) The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 6:13
Article PubMed PubMed Central Google Scholar
Rőszer T (2015) Understanding the mysterious M2 macrophage through activation markers and effector mechanisms. Mediators Inflamm 2015:816460
Article PubMed PubMed Central Google Scholar
Arora S, Dev K, Agarwal B, Das P, Syed MA (2018) Macrophages: their role, activation and polarization in pulmonary diseases. Immunobiology 223(4–5):383–396
Article CAS PubMed Google Scholar
Almansour S, Dunster JL, Crofts JJ, Nelson MR (2024) Modelling the continuum of macrophage phenotypes and their role in inflammation. Math Biosci 377:109289
Article CAS PubMed Google Scholar
Gaga M, Bentley AM, Humbert M, Barkans J, O’Brien F, Wathen CG et al (1998) Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin 8 positive cells in the airways of patients with bronchiectasis. Thorax 53(8):685–691
Article CAS PubMed PubMed Central Google Scholar
Zheng L, Shum H, Tipoe GL, Leung R, Lam WK, Ooi GC et al (2001) Macrophages, neutrophils and tumour necrosis factor-alpha expression in bronchiectatic airways in vivo. Respir Med 95(10):792–798
Article CAS PubMed Google Scholar
Asakura T, Okuda K, Chen G, Dang H, Kato T, Mikami Y et al (2024) Proximal and distal bronchioles contribute to the pathogenesis of non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 209(4):374–389
Article CAS PubMed Google Scholar
Lucas JS, Gahleitner F, Amorim A, Boon M, Brown P, Constant C et al (2019) Pulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trials. ERJ Open Res. https://doi.org/10.1183/23120541.00147-2018
Article PubMed PubMed Central Google Scholar
Hovold G, Palmcrantz V, Kahn F, Egesten A, Påhlman LI (2018) Heparin-binding protein in sputum as a marker of pulmonary inflammation, lung function, and bacterial load in children with cystic fibrosis. BMC Pulm Med 18(1):104
Article PubMed PubMed Central Google Scholar
Diemer S, Chowdhury S, Sahl C, Happonen L, Påhlman LI (2025) Characterisation of airway inflammation and proteomes associated with cystic fibrosis-related diabetes. ERJ Open Res. https://doi.org/10.1183/23120541.00290-2025
Article PubMed PubMed Central Google Scholar
Schmidt T, Berthold E, Arve-Butler S, Gullstrand B, Mossberg A, Kahn F et al (2020) Children with oligoarticular juvenile idiopathic arthritis have skewed synovial monocyte polarization pattern with functional impairment-a distinct inflammatory pattern for oligoarticular juvenile arthritis. Arthritis Res Ther 22(1):186
Article CAS PubMed PubMed Central Google Scholar
Ohlsson SM, Linge CP, Gullstrand B, Lood C, Johansson A, Ohlsson S et al (2014) Serum from patients with systemic vasculitis induces alternatively activated macrophage M2c polarization. Clin Immunol 152(1–2):10–19
Article CAS PubMed Google Scholar
Almubarak A, Tanagala KKK, Papapanou PN, Lalla E, Momen-Heravi F (2020) Disruption of Monocyte and Macrophage Homeostasis in Periodontitis. Front Immunol 11:330
Article CAS PubMed PubMed Central Google Scholar
Yamaguchi Y, Gibson J, Ou K, Lopez LS, Ng RH, Leggett N et al (2022) PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages. J Immunother Cancer. https://doi.org/10.1136/jitc-2021-004400
Article PubMed PubMed Central Google Scholar
Unuvar Purcu D, Korkmaz A, Gunalp S, Helvaci DG, Erdal Y, Dogan Y et al (2022) Effect of stimulation time on the expression of human macrophage polarization markers. PLoS ONE 17(3):e0265196
Article CAS PubMed PubMed Central Google Scholar
Cutolo M, Campitiello R, Gotelli E, Soldano S (2022) The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis. Front Immunol 13:867260
Article CAS PubMed PubMed Central Google Scholar
Vogel DY, Glim JE, Stavenuiter AW, Breur M, Heijnen P, Amor S et al (2014) Human macrophage polarization in vitro: maturation and activation methods compared. Immunobiology 219(9):695–703
Article CAS PubMed Google Scholar
Perea L, Bottier M, Cant E, Richardson H, Dicker AJ, Shuttleworth M et al (2024) Airway IL-1β is related to disease severity and mucociliary function in bronchiectasis. Eur Respir J. https://doi.org/10.1183/13993003.01966-2023
Schmidt T, Dahlberg A, Berthold E, Król P, Arve-Butler S, Rydén E et al (2023) Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions. Front Immunol 14:1190018
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