Porsbjerg C, Melen E, Lehtimaki L, Shaw D, Asthma (2023) Lancet 401(10379):858–873
Diseases GBD, Injuries C (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet 396(10258):1204–1222
Emmerich SD, Fryar CD, Stierman B, Ogden CL Obesity and Severe Obesity Prevalence in Adults: United States, August 2021-August 2023. NCHS Data Brief. 2024(508)
Collaborators GUOF (2024) National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050. Lancet 404(10469):2278–2298
Beuther DA, Sutherland ER (2007) Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 175(7):661–666
Article PubMed PubMed Central Google Scholar
Al-Lawati F, Al-Mubaihsi SM, Jayakrishnan B, Rizvi S, Al-Abri MA (2022) Obstructive sleep apnea in patients with severe asthma: prevalence and association between severity and asthma control. Ann Thorac Med 17(2):118–123
Article PubMed PubMed Central Google Scholar
Muller TD, Finan B, Bloom SR, D’Alessio D, Drucker DJ, Flatt PR et al (2019) Glucagon-like peptide 1 (GLP-1). Mol Metab 30:72–130
Article PubMed PubMed Central CAS Google Scholar
Foer D, Beeler PE, Cui J, Karlson EW, Bates DW, Cahill KN (2021) Asthma exacerbations in patients with type 2 diabetes and asthma on Glucagon-like Peptide-1 receptor agonists. Am J Respir Crit Care Med 203(7):831–840
Article PubMed PubMed Central CAS Google Scholar
Albogami Y, Cusi K, Daniels MJ, Wei YJ, Winterstein AG (2021) Glucagon-Like peptide 1 receptor agonists and chronic lower respiratory disease exacerbations among patients with type 2 diabetes. Diabetes Care 44(6):1344–1352
Article PubMed PubMed Central CAS Google Scholar
Khan F, Mat A, Hogan AE, Kent BD, Eigenheer S, Corrigan MA et al (2017) Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy. QJM 110(12):853–854
Article PubMed CAS Google Scholar
Goldin J, Hashmi MF, Cataletto ME, Asthma StatPearls. Treasure Island (FL)2025.
Dixon AE, Holguin F, Sood A, Salome CM, Pratley RE, Beuther DA et al (2010) An official American thoracic society workshop report: obesity and asthma. Proc Am Thorac Soc 7(5):325–335
Kuruvilla ME, Lee FE, Lee GB (2019) Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clin Rev Allergy Immunol 56(2):219–233
Article PubMed PubMed Central Google Scholar
Dixon AE, Poynter ME, Garrow OJ, Kaminsky DA, Tharp WG, Bates JHT (2023) Peripheral airway dysfunction in obesity and obese asthma. Chest 163(4):753–762
Article PubMed PubMed Central Google Scholar
Althoff MD, Gaietto K, Holguin F, Forno E (2024) Obesity-related asthma: a Pathobiology-based overview of existing and emerging treatment approaches. Am J Respir Crit Care Med 210(10):1186–1200
Article PubMed PubMed Central CAS Google Scholar
Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID (2002) Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 57(10):875–879
Article PubMed PubMed Central CAS Google Scholar
Hamid Q, Tulic MK, Liu MC, Moqbel R (2003) Inflammatory cells in asthma: mechanisms and implications for therapy. J Allergy Clin Immunol 111(1 Suppl):S5–S12 discussion S-7
Article PubMed CAS Google Scholar
Peebles RS Jr., Aronica MA (2019) Proinflammatory pathways in the pathogenesis of asthma. Clin Chest Med 40(1):29–50
Article PubMed PubMed Central Google Scholar
Peters U, Dixon AE, Forno E (2018) Obesity and asthma. J Allergy Clin Immunol 141(4):1169–1179
Article PubMed PubMed Central Google Scholar
Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC et al (2020) Evidence for exacerbation-Prone asthma and predictive biomarkers of exacerbation frequency. Am J Respir Crit Care Med 202(7):973–982
Article PubMed PubMed Central CAS Google Scholar
Wu TD, Brigham EP, Keet CA, Brown TT, Hansel NN, McCormack MC (2019) Association between prediabetes/diabetes and asthma exacerbations in a claims-based obese asthma cohort. J Allergy Clin Immunol Pract 7(6):1868–73e5
Article PubMed PubMed Central Google Scholar
Price D, Wilson AM, Chisholm A, Rigazio A, Burden A, Thomas M et al (2016) Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice. J Asthma Allergy 9:1–12
PubMed PubMed Central CAS Google Scholar
Egan KB, Ettinger AS, Bracken MB (2013) Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatr 13:121
Article PubMed PubMed Central Google Scholar
Parasuaraman G, Ayyasamy L, Aune D, Sen A, Nagarajan R, Rajkumar P et al (2023) The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies. Sci Rep 13(1):7745
Article PubMed PubMed Central CAS Google Scholar
Maalej S, Yaacoub Z, Fakhfekh R, Yaalaoui S, Kheder AB, Drira I (2012) Association of obesity with asthma severity, control and quality of life. Tanaffos 11(1):38–43
PubMed PubMed Central CAS Google Scholar
Mosen DM, Schatz M, Magid DJ, Camargo CA (2008) Jr. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol 122(3):507–511 e6
Thompson CA, Eslick SR, Berthon BS, Wood LG (2021) Asthma medication use in obese and healthy weight asthma: systematic review/meta-analysis. Eur Respir J. ;57(3)
Holguin F, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Erzurum SC et al (2011) Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol 127(6):1486–1493e2
Article PubMed PubMed Central Google Scholar
Buescher PA, Whitmire JT, Plescia M (2008) Relationship between body mass index and medical care expenditures for North Carolina adolescents enrolled in medicaid in 2004. Prev Chronic Dis 5(1):A04
Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY (2008) Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 178(7):682–687
Article PubMed PubMed Central CAS Google Scholar
Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM (2006) Influence of body mass index on the response to asthma controller agents. Eur Respir J 27(3):495–503
Article PubMed CAS Google Scholar
Liu Y, Zheng J, Zhang HP, Zhang X, Wang L, Wood L et al (2018) Obesity-Associated metabolic signatures correlate to clinical and inflammatory profiles of asthma: A pilot study. Allergy Asthma Immunol Res 10(6):628–647
Article PubMed PubMed Central CAS Google Scholar
Gellert GA, Nowicka A, Marecka M, Gellert GL, Price T, Demographics (2025) Comorbidities, and Care-Seeking intent among individuals with obesity or overweight status using outpatient AI-Based virtual triage. Telemed Rep 6(1):139–147
Comments (0)