Merriel SW, D, et al. Retrospective cohort study evaluating clinical, biochemical and Pharmacological prognostic factors for prostate cancer progression using primary care data. BMJ Open. 2021;11:e044420.
Article PubMed PubMed Central Google Scholar
Knight S, Shaw C, Pius R, GlobalSurg, Collaborative, National Institute for Health Research Global Health Research Unit on Global Surgery. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries. Lancet. 2021;397:387–97.
Liu B, et al. Exploring treatment options in cancer: tumor treatment strategies. Signal Transduct Target Therapy. 2024;9:175.
Ratajczak MZ, et al. Cancer from the perspective of stem cells and misappropriated tissue regeneration mechanisms. Leukemia. 2018;32:2519–26.
Article CAS PubMed PubMed Central Google Scholar
Bustan H, Herz A. In vitro determination and differentiation of mouse teratocarcinoma toward myocardiogenesis. Dev Biol. 1977;59:1–11.
Article CAS PubMed Google Scholar
Chaudhary A, Raza SS, Haque R. Transcriptional factors targeting in cancer stem cells for tumor modulation. in YSCB. 2023. Elsevier.
Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer. 2005;5:275–84.
Article CAS PubMed Google Scholar
Krivtsov AV, et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9. Nature. 2006;442:818–22.
Article CAS PubMed Google Scholar
Lin J-H, et al. Oestrogen receptor-regulated glutathione S-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers Tamoxifen resistance on breast cancer cells. Breast Cancer Res Treat. 2018;172:45–59.
Article CAS PubMed Google Scholar
Yu K-D, et al. Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. Breast Cancer Res Treat. 2010;121:485–96.
Article CAS PubMed Google Scholar
Razandi M, et al. Tamoxifen regulates cell fate through mitochondrial Estrogen receptor beta in breast cancer. Oncogene. 2013;32:3274–85.
Article CAS PubMed Google Scholar
Kocdogan AK, et al. Investigation of GST and drug resistance protein expressions in relation to chemotherapy in breast cancer. Health Probl Civiliz. 2025;19:148–62.
Liu R et al. Identifying CTSF and GSTM3 as chemoresistance therapeutic targets in breast cancer through multi-omics MR analysis. iScience. 2025; 28:1–16.
Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003;22:7369–75.
Article CAS PubMed PubMed Central Google Scholar
Depeille P, et al. Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects. Mol Pharmacol. 2004;65:897–905.
Article CAS PubMed Google Scholar
Talib WH, et al. Targeting drug chemo-resistance in cancer using natural products. Biomedicines. 2021;9:1353.
Article CAS PubMed PubMed Central Google Scholar
Seven D, Dalan AB, Bayrak ÖF. Targeting GSTM3 for therapeutic potential in advanced prostate cancer. BMC Cancer. 2025;25:1493.
Article CAS PubMed PubMed Central Google Scholar
Singh RR, Reindl KM. Glutathione S-transferases in cancer. Antioxidants. 2021;10:701.
Article CAS PubMed PubMed Central Google Scholar
Drozd E, et al. Up-regulation of glutathione-related genes, enzyme activities and transport proteins in human cervical cancer cells treated with doxorubicin. Biomed Pharmacother. 2016;83:397–406.
Article CAS PubMed Google Scholar
Zahmatkesh AK, Moqadami A, Khalaj-Kondori M. Insights into the radiotherapy-induced deferentially expressed RNAs in colorectal cancer management. Iran J Basic Med Sci. 2023;26:1380.
Alden RS, et al. Glutamine metabolism and radiosensitivity: beyond the Warburg effect. Front Oncol. 2022;12:1070514.
Article CAS PubMed PubMed Central Google Scholar
McBrayer SK, et al. Transaminase Inhibition by 2-hydroxyglutarate impairs glutamate biosynthesis and redox homeostasis in glioma. Cell. 2018;175:101–16. e25.
Article CAS PubMed PubMed Central Google Scholar
Rashmi R, et al. Glutaminase inhibitors induce thiol-mediated oxidative stress and radiosensitization in treatment-resistant cervical cancers. Mol Cancer Ther. 2020;19:2465–75.
Article CAS PubMed PubMed Central Google Scholar
Wei Z, et al. Metabolism of amino acids in cancer. Front Cell Dev Biology. 2021;8:603837.
Zahmatkesh AK, et al. GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis. EXCLI J. 2023;22:847.
Fu S, et al. Glutamine synthetase promotes radiation resistance via facilitating nucleotide metabolism and subsequent DNA damage repair. Cell Rep. 2019;28:1136–43. e4.
Article CAS PubMed Google Scholar
Peng Y, et al. Glutamine synthetase facilitates cancer cells to recover from irradiation-induced G2/M arrest. Cancer Biol Ther. 2020;21:43–51.
Article CAS PubMed Google Scholar
Vardhana SA, et al. Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metabolism. 2019;1:676–87.
Ma J, et al. Emerging roles for fatty acid oxidation in cancer. Genes Dis. 2025;12:101491.
Article CAS PubMed Google Scholar
Schafer ZT, et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009;461:109–13.
Article CAS PubMed PubMed Central Google Scholar
Carracedo A, et al. A metabolic prosurvival role for PML in breast cancer. J Clin Investig. 2012;122:3088–100.
Article CAS PubMed PubMed Central Google Scholar
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759–67.
Article CAS PubMed Google Scholar
Carethers JM, Jung BH. Genetics and genetic biomarkers in sporadic colorectal cancer. Gastroenterology. 2015;149:1177–90. e3.
Article CAS PubMed PubMed Central Google Scholar
Testa U, Pelosi E, Castelli G. Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. Med Sci. 2018;6:31.
Khalek FJA, Gallicano GI, Mishra L. Colon cancer stem cells. Gastrointest Cancer Research: GCR. 2010; Nov-Dec;(Suppl 1):S16–S.
Ben-Porath I, et al. An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 2008;40:499–507.
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