Early recognition of atypical hemolytic uremic syndrome to prevent irreversible kidney injury: cardiac failure and refractory hypertension as critical clues in young patients

Manrique-Caballero CL, et al. Typical and atypical hemolytic uremic syndrome in the critically ill. Crit Care Clin. 2020;36(2):333–56.

Article  PubMed  Google Scholar 

Tsai HM. Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. Am J Med. 2013;126(3):200–9.

Article  PubMed  Google Scholar 

Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001;60(3):831–46.

Article  CAS  PubMed  Google Scholar 

Yenerel MN. Atypical hemolytic uremic syndrome: differential diagnosis from TTP/HUS and management. Turk J Haematol. 2014;31(3):216–25.

PubMed  PubMed Central  Google Scholar 

Jokiranta TS. HUS and atypical HUS. Blood. 2017;129(21):2847–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cody EM, Dixon BP. Hemolytic uremic syndrome. Pediatr Clin North Am. 2019;66(1):235–46.

Article  PubMed  Google Scholar 

Fakhouri F, et al. Haemolytic uraemic syndrome. Lancet. 2017;390(10095):681–96.

Article  PubMed  Google Scholar 

Loirat C, Frémeaux-Bacchi V. Atypical hemolytic uremic syndrome. Orphanet J Rare Dis. 2011;6(1):60.

Article  PubMed  PubMed Central  Google Scholar 

Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002;347(8):589–600.

Article  CAS  PubMed  Google Scholar 

Noris M, Remuzzi G. Cardiovascular complications in atypical haemolytic uraemic syndrome. Nat Rev Nephrol. 2014;10(3):174–80.

Article  PubMed  Google Scholar 

Remuzzi G, Ruggenenti P, Bertani T. Renal pathology: with clinical and functional correlations. Philadelphia: JB Lippincott Company; 1994. p. 1154.

Google Scholar 

Noris M, Remuzzi G. Atypical hemolytic–uremic syndrome. N Engl J Med. 2009;361(17):1676–87.

Article  CAS  PubMed  Google Scholar 

Legendre C, et al. Terminal complement inhibitor eculizumab in atypical hemolytic–uremic syndrome. N Engl J Med. 2013;368(23):2169–81.

Article  CAS  PubMed  Google Scholar 

Joseph A, et al. Shiga toxin-associated hemolytic uremic syndrome: a narrative review. Toxins (Basel). 2020;12(2):1–46.

Article  Google Scholar 

Liu Y, et al. Diagnosis and treatment for Shiga toxin-producing Escherichia coli associated hemolytic uremic syndrome. Toxins (Basel). 2022;15(1):1–28.

Article  Google Scholar 

Nester CM, Thomas CP. Atypical hemolytic uremic syndrome: What is it, how is it diagnosed, and how is it treated? Hematol 2010, Am Soc Hematol Educ Program. 2012;2012(1):617–625.

Zuber J, et al. Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies. Nat Rev Nephrol. 2012;8(11):643–57.

Article  CAS  PubMed  Google Scholar 

Noris M, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010;5(10):1844–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bu F, et al. Comprehensive genetic analysis of complement and coagulation genes in atypical hemolytic uremic syndrome. J Am Soc Nephrol. 2014;25(1):55–64.

Article  CAS  PubMed  Google Scholar 

Loirat C, Noris M, Fremeaux-Bacchi V. Complement and the atypical hemolytic uremic syndrome in children. Pediatr Nephrol. 2008;23(11):1957–72.

Article  PubMed  PubMed Central  Google Scholar 

Campbell CM, et al. Atypical haemolytic uraemic syndrome: a case report of a rare cause of reversible cardiomyopathy. Eur Heart J Case Rep. 2020;4(2):1–6.

Article  PubMed  PubMed Central  Google Scholar 

Hu H, et al. Eculizumab in atypical haemolytic uraemic syndrome with severe cardiac and neurological involvement. Pediatr Nephrol. 2014;29(6):1103–6.

Article  PubMed  Google Scholar 

Leventoglu E, et al. Secondary Cardiorenal syndromes in children: focus on Type 3 to 5 cardiorenal syndrome. Cardiorenal Med. 2025;15(1):358–73.

Article  CAS  PubMed  Google Scholar 

Marzuillo P, et al. Acquired long QT syndrome: a focus for the general pediatrician. Pediatr Emerg Care. 2014;30(4):257–61.

Article  PubMed  Google Scholar 

Dubois EA, Cohen AF. Eculizumab. Br J Clin Pharmacol. 2009;68(3):318–9.

Article  PubMed  PubMed Central  Google Scholar 

Chen FY, Chen CH, Lin CC. Hypertensive crisis and refractory hypertension caused by atypical hemolytic uremic syndrome and effect of eculizumab. Acta Cardiol Sin. 2018;34(5):446–9.

PubMed  PubMed Central  Google Scholar 

Gami AS, et al. Incidence and prognosis of acute heart failure in the thrombotic microangiopathies. Am J Med. 2005;118(5):544–7.

Article  PubMed  Google Scholar 

Nester CM, et al. Atypical aHUS: state of the art. Mol Immunol. 2015;67(1):31–42.

Article  CAS  PubMed  Google Scholar 

Licht C, et al. Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies. Kidney Int. 2015;87(5):1061–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vaughn JL, Moore JM, Cataland SR. Acute systolic heart failure associated with complement-mediated hemolytic uremic syndrome. Case Rep Hematol. 2015;2015(1):327980.

PubMed  PubMed Central  Google Scholar 

Filip C, et al. Cardiovascular complications of hemolytic uremic syndrome in children. Maedica (Bucur). 2020;15(3):305–9.

PubMed  PubMed Central  Google Scholar 

Ivanova E, et al. POS-008 extrarenal manifestations of atypical hemolytic uremic syndrome: cardiac and lung involvement. Kidney Int Rep. 2022;7(6):S440.

Article  Google Scholar 

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