Associations of the Triglyceride-Glucose Index and Body Fat Composition with Blood Pressure in Children and Adolescents

Jeong SI, Kim SH. Obesity and hypertension in children and adolescents. Clin Hypertens. 2024;30:23.

Article  PubMed  PubMed Central  Google Scholar 

Collaboration NCDRF. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398:957–80.

Article  Google Scholar 

Zhou J, Wu J, Jiang D, Cai S, Zhang C, Ying J, et al. National, regional and provincial prevalence of childhood hypertension in China in 2020: a systematic review and modelling study. Lancet Child Adolesc Health. 2024;8:872–81.

Article  PubMed  Google Scholar 

Price JJ, Urbina EM, Carlin K, Becker R, Daniels SR, Falkner BE, et al. Cardiovascular risk factors and target organ damage in adolescents: the SHIP AHOY study. Pediatrics. 2022. https://doi.org/10.1542/peds.2021-054201.

Article  PubMed  PubMed Central  Google Scholar 

Raitakari OT, Juonala M, Kahonen M, Taittonen L, Laitinen T, Maki-Torkko N, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the cardiovascular risk in young Finns study. JAMA. 2003;290:2277–83.

Article  CAS  PubMed  Google Scholar 

Delvecchio M, Pastore C, Valente F, Giordano P. Cardiovascular implications in idiopathic and syndromic obesity in childhood: an update. Front Endocrinol (Lausanne). 2020;11:330.

Article  PubMed  Google Scholar 

Oh R, Kim S, Park SH, Jang M, Cho SH, Kim JY, et al. Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study. Cardiovasc Diabetol. 2025;24:150.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, Guo H, Sun Z, Zhang D, Lin Y, Huang L, et al. Associations of modified triglyceride-glucose indices and the triglyceride/high-density lipoprotein ratio with all-cause and cause-specific mortality in the general population: an analysis of the UK biobank database. Lipids Health Dis. 2025;24:126.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cabanillas-Lazo M, Quispe-Vicuna C, Pascual-Guevara M, Cruzalegui-Bazan C, Duran-Pecho A, Paz-Ibarra J, et al. Diagnostic accuracy of triglyceride to glucose index and triglyceride/high-density lipoprotein index for insulin resistance among children and adolescents: a systematic review. PLoS ONE. 2025;20:e0326179.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Yang W, Jiang X. Association between triglyceride-glucose index and hypertension: a meta-analysis. Front Cardiovasc Med. 2021;8:644035.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Cao TY, Li JQ, Ding CC, Li JP, Ying HB, et al. Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults. J Geriatr Cardiol. 2022;19:753–60.

CAS  PubMed  PubMed Central  Google Scholar 

Agbaje AO. Arterial stiffness preceding metabolic syndrome in 3862 adolescents: a mediation and temporal causal longitudinal birth cohort study. Am J Physiol-Heart Circul Physiol. 2023;324:H905–11.

Article  CAS  Google Scholar 

He H, Pan L, Du J, Liu F, Jin Y, Ma J, et al. Body composition and serum total calcium were associated with blood pressure among children and adolescents aged 7–18 in China: a cross-sectional study. Front Pediatr. 2019;7:411.

Article  PubMed  PubMed Central  Google Scholar 

Yu S, Zhao S, Tang J, Zhao Y, Xu C, Li M, et al. Fat-free mass may play a dominant role in the association between systolic blood pressure and body composition in children and adolescents. Br J Nutr. 2024;131:622–9.

Article  CAS  PubMed  Google Scholar 

Mao B, Zhang J, Li S, Fan Z, Deng Y, Quan H, et al. Association of body composition with ambulatory blood pressure among Chinese youths. BMC Pediatr. 2024;24:566.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwarteng EA, Shank LM, Faulkner LM, Loch LK, Fatima S, Gupta S, et al. Influence of puberty on relationships between body composition and blood pressure: a cross-sectional study. Pediatr Res. 2023;94:781–8.

Article  PubMed  PubMed Central  Google Scholar 

Yang ZY, Zhang Q, Zhai Y, Xu T, Wang YY, Chen BW, et al. National nutrition and health systematic survey for children 0–17 years of age in China. Biomed Environ Sci. 2021;34:891–9.

CAS  PubMed  Google Scholar 

Simental-Mendia LE, Rodriguez-Moran M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6:299–304.

Article  CAS  PubMed  Google Scholar 

Wu K, Zheng H, Wu W, Chen G, Cai Z, Cai Z, et al. Temporal relationship between triglyceride-glucose index and blood pressure and their joint cumulative effect on cardiovascular disease risk: a longitudinal cohort study. Cardiovasc Diabetol. 2023;22:332.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diez-Fernandez A, Sanchez-Lopez M, Nieto JA, Gonzalez-Garcia A, Miota-Ibarra J, Ortiz-Galeano I, et al. Relationship between cardiorespiratory fitness and blood pressure in young adults: a mediation analysis of body composition. Hypertens Res. 2017;40:511–5.

Article  PubMed  Google Scholar 

Wang D, Li W, Zhou M, Ma J, Guo Y, Yuan J, et al. Association of the triglyceride-glucose index variability with blood pressure and hypertension: a cohort study. QJM. 2024;117:277–82.

Article  CAS  PubMed  Google Scholar 

Gao L, Zhang S, Li S, Luo M, Lin P, Zhao Z, et al. Association of insulin resistance surrogates with disease severity and adverse outcomes in chronic thromboembolic pulmonary hypertension: a multicenter cohort study. Cardiovasc Diabetol. 2025;24:82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hall JE, Do Carmo JM, Da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res. 2015;116:991–1006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rao A, Pandya V, Whaley-Connell A. Obesity and insulin resistance in resistant hypertension: implications for the kidney. Adv Chronic Kidney Dis. 2015;22:211–7.

Article  PubMed  Google Scholar 

Horita S, Seki G, Yamada H, Suzuki M, Koike K, Fujita T. Insulin resistance, obesity, hypertension, and renal sodium transport. Int J Hypertens. 2011;2011:391762.

Article  PubMed  PubMed Central  Google Scholar 

Wheatcroft SB, Williams IL, Shah AM, Kearney MT. Pathophysiological implications of insulin resistance on vascular endothelial function. Diabet Med. 2003;20:255–68.

Article  CAS  PubMed  Google Scholar 

Arlien-Soborg MC, Madsen MA, Dal J, Krusenstjerna-Hafstrom T, Ringgaard S, Skou N, et al. Ectopic lipid deposition and insulin resistance in patients with GH disorders before and after treatment. Eur J Endocrinol. 2023;188:78.

Article  Google Scholar 

Wu FZ, Wu CC, Kuo PL, Wu MT. Differential impacts of cardiac and abdominal ectopic fat deposits on cardiometabolic risk stratification. BMC Cardiovasc Disord. 2016;16:20.

Article  PubMed  PubMed Central  Google Scholar 

Birhanu MM, Zengin A, Joshi R, Evans RG, Kalyanram K, Kartik K, et al. Risk factors for incident cardiovascular events and their population attributable fractions in rural India: the Rishi valley prospective cohort study. Trop Med Int Health. 2024;29:377–89.

Article  PubMed  Google Scholar 

Zhang Q, Kong B, Zhou Z, Liu F, Wen E, Lin B, et al. Association between systemic immune-inflammation index and central obesity in pediatric populations: a cross-sectional and cohort study. Front Immunol. 2025;16:1546612.

Article  CAS 

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