Diastolic Function Unchanged After Lifestyle Intervention Despite Improved VO in Pediatric Heart Transplant Patients

Colvin MM, Smith JM, Ahn YS et al (2025) OPTN/SRTR 2023 annual data report: heart. Am J Transplant 25(2):S329–S421. https://doi.org/10.1016/j.ajt.2025.01.024

Article  PubMed  PubMed Central  Google Scholar 

Hayes EA, Koehl D, Cantor R et al (2025) Long‐term survival in children following heart transplantation. Pediatr Transplant 29(2):e70042. https://doi.org/10.1111/petr.70042

Article  PubMed  CAS  Google Scholar 

Singh TP, Hsich E, Cherikh WS et al (2025) The international thoracic organ transplant registry of the International Society for Heart and Lung Transplantation: 2025 annual report of heart and lung transplantation. J Heart Lung Transplant. https://doi.org/10.1016/j.healun.2025.04.014

Article  PubMed  Google Scholar 

Peterson S, Su JA, Szmuszkovicz JR, Johnson R, Sargent B (2017) Exercise capacity following pediatric heart transplantation: a systematic review. Pediatr Transplant 21(5):e12922. https://doi.org/10.1111/petr.12922

Article  Google Scholar 

Chen AC, Ramirez FD, Rosenthal DN et al (2020) Healthy hearts via live videoconferencing: an exercise and diet intervention in pediatric heart transplant recipients. J Am Heart Assoc 9(3):e013816. https://doi.org/10.1161/JAHA.119.013816

Article  PubMed  PubMed Central  Google Scholar 

Chen AC, Rosenthal DN, Couch SC et al (2019) Healthy hearts in pediatric heart transplant patients with an exercise and diet intervention via live video conferencing—design and rationale. Pediatr Transplant 23(1):e13316. https://doi.org/10.1111/petr.13316

Article  PubMed  CAS  Google Scholar 

Patel JN, Kavey R, Pophal SG, Trapp EE, Jellen G, Pahl E (2008) Improved exercise performance in pediatric heart transplant recipients after home exercise training. Pediatr Transplant 12(3):336–340. https://doi.org/10.1111/j.1399-3046.2007.00806.x

Article  PubMed  Google Scholar 

Deliva RD, Hassall A, Manlhiot C, Solomon M, McCrindle BW, Dipchand AI (2012) Effects of an acute, outpatient physiotherapy exercise program following pediatric heart or lung transplantation. Pediatr Transplant 16(8):879–886. https://doi.org/10.1111/petr.12003

Article  PubMed  CAS  Google Scholar 

Tallaj JA, Kirklin JK, Brown RN et al (2007) Post-heart transplant diastolic dysfunction is a risk factor for mortality. J Am Coll Cardiol 50(11):1064–1069. https://doi.org/10.1016/j.jacc.2007.06.007

Article  PubMed  Google Scholar 

Eun LY, Gajarski RJ, Graziano JN, Ensing GJ (2005) Relation of left ventricular diastolic function as measured by echocardiography and pulmonary capillary wedge pressure to rejection in young patients (≤31 years) after heart transplantation. Am J Cardiol 96(6):857–860. https://doi.org/10.1016/j.amjcard.2005.04.060

Article  PubMed  Google Scholar 

Lunze FI, Colan SD, Gauvreau K et al (2012) Cardiac allograft function during the first year after transplantation in rejection-free children and young adults. Circ Cardiovasc Imaging 5(6):756–764. https://doi.org/10.1161/CIRCIMAGING.112.976613

Article  PubMed  Google Scholar 

Mahle WT, Cardis BM, Ketchum D, Vincent RN, Kanter KR, Fyfe DA (2006) Reduction in initial ventricular systolic and diastolic velocities after heart transplantation in children: improvement over time identified by tissue doppler imaging. J Heart Lung Transplant 25(11):1290–1296. https://doi.org/10.1016/j.healun.2006.08.003

Article  PubMed  Google Scholar 

Lopez L, Colan SD, Frommelt PC et al (2010) Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the pediatric measurements writing group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr 23(5):465–495. https://doi.org/10.1016/j.echo.2010.03.019

Article  PubMed  Google Scholar 

Broch K, Al-Ani A, Gude E, Gullestad L, Aakhus S (2014) Echocardiographic evaluation of left ventricular filling pressure in heart transplant recipients. Scand Cardiovasc J 48(6):349–356. https://doi.org/10.3109/14017431.2014.981579

Article  PubMed  Google Scholar 

Bech‐Hanssen O, Al‐Habeeb W, Ahmed W et al (2015) Echocardiography detects elevated left ventricular filling pressures in heart transplant recipients. Echocardiography 32(3):411–419. https://doi.org/10.1111/echo.12683

Article  PubMed  Google Scholar 

Ommen SR, Nishimura RA, Appleton CP et al (2000) Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation 102(15):1788–1794. https://doi.org/10.1161/01.CIR.102.15.1788

Article  PubMed  CAS  Google Scholar 

Wisotzkey BL, Haileselassie B, Jorgensen N et al (2022) Estimating filling pressures in paediatric heart transplant recipients using echocardiographic parameters and B-type natriuretic peptide. Cardiol Young 32(4):531–538. https://doi.org/10.1017/S104795112100247X

Article  PubMed  Google Scholar 

Alfares FA, Nanjegowda C, Swaminathan S et al (2024) Echocardiography to predict left ventricular filling pressure for long-term paediatric heart transplant patients. Cardiol Young 34(8):1799–1804. https://doi.org/10.1017/S1047951124000908

Article  PubMed  Google Scholar 

Yeh J, Aiyagari R, Gajarski RJ, Zamberlan MC, Lu JC (2015) Left atrial deformation predicts pulmonary capillary wedge pressure in pediatric heart transplant recipients. Echocardiography 32(3):535–540. https://doi.org/10.1111/echo.12679

Article  PubMed  Google Scholar 

Sachdeva R, Malik S, Seib PM, Frazier EA, Cleves MA (2011) Doppler tissue imaging and catheter-derived measures are not independent predictors of rejection in pediatric heart transplant recipients. Int J Cardiovasc Imaging 27(7):947–954. https://doi.org/10.1007/s10554-010-9747-4

Article  PubMed  Google Scholar 

Lunze FI, Narciso R, Gauvreau K, Blume ED, Colan SD, Singh TP (2019) Is Doppler echocardiography useful for estimating left ventricular filling pressures in pediatric heart transplant recipients? Pediatr Transplant 23(7):e13543. https://doi.org/10.1111/petr.13543

Article  PubMed  Google Scholar 

Savage A, Hlavacek A, Ringewald J, Shirali G (2010) Evaluation of the myocardial performance index and tissue Doppler imaging by comparison to near-simultaneous catheter measurements in pediatric cardiac transplant patients. J Heart Lung Transplant 29(8):853–858. https://doi.org/10.1016/j.healun.2010.03.014

Article  PubMed  Google Scholar 

Panesar DK, Burch M (2017) Assessment of diastolic function in congenital heart disease. Front Cardiovasc Med. https://doi.org/10.3389/fcvm.2017.00005

Article  PubMed  PubMed Central  Google Scholar 

Loar RW, Pignatelli RH, Morris SA et al (2020) Left atrial strain correlates with elevated filling pressures in pediatric heart transplantation recipients. J Am Soc Echocardiogr 33(4):504-511.e1. https://doi.org/10.1016/j.echo.2019.11.004

Article  PubMed  Google Scholar 

Stewart S, Winters GL, Fishbein MC et al (2005) Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 24(11):1710–1720. https://doi.org/10.1016/j.healun.2005.03.019

Article  PubMed  Google Scholar 

Velleca A, Shullo MA, Dhital K et al (2023) The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant 42(5):e1–e141. https://doi.org/10.1016/j.healun.2022.10.015

Article  PubMed  Google Scholar 

Berry GJ, Burke MM, Andersen C et al (2013) The 2013 International Society for Heart and Lung Transplantation working formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. J Heart Lung Transplant 32(12):1147–1162. https://doi.org/10.1016/j.healun.2013.08.011

Article  PubMed  Google Scholar 

Lopez L, Saurers DL, Barker PCA et al (2024) Guidelines for performing a comprehensive pediatric transthoracic echocardiogram: recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr 37(2):119–170. https://doi.org/10.1016/j.echo.2023.11.015

Article  PubMed  Google Scholar 

Badano LP, Kolias TJ, Muraru D et al (2018) Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry task force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging 19(6):591–600. https://doi.org/10.1093/ehjci/jey042

Article  PubMed  Google Scholar 

Friedberg MK, Silverman NH, Dubin AM, Rosenthal DN (2007) Right ventricular mechanical dyssynchrony in children with hypoplastic left heart syndrome. J Am Soc Echocardiogr 20(9):1073–1079. https://doi.org/10.1016/j.echo.2007.02.015

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