Effect of Hydroxytyrosol on OTULIN Levels in Testıcular Tıssue in Experımental Dıabetes Model Induced wıth Streptozotocin

Baloglu FK, Tas DG, Yilmaz O, Severcan F. The recovery effect of Vitamin C on structural alterations due to Streptozotocin-Induced diabetes in rat testicular tissues. Spectrochim Acta Part A Mol Biomol Spectrosc. 2023;288:122149.

Article  Google Scholar 

He Z, Yin G, Li QQ, Zeng Q, Duan J. Diabetes mellitus causes male reproductive dysfunction: A review of the evidence and mechanisms. vivo. 2021;35(5):2503–11.

Article  CAS  Google Scholar 

Sampannang A, Arun S, Burawat J, Sukhorum W, Iamsaard S. Testicular histopathology and phosphorylated protein changes in mice with diabetes induced by multiple-low doses of streptozotocin: An experimental study. Int J Reproductive Biomed. 2018;16(4):235.

CAS  Google Scholar 

Nna VU, Abu Bakar AB, Ahmad A, Eleazu CO, Mohamed M. Oxidative stress, NF-κb-mediated inflammation and apoptosis in the testes of streptozotocin–induced diabetic rats: Combined protective effects of malaysian propolis and metformin. Antioxidants. 2019;8(10):465.

Article  PubMed  PubMed Central  Google Scholar 

Condorelli RA, La Vignera S, Mongioì LM, Alamo A, Calogero AE. Diabetes mellitus and infertility: different pathophysiological effects in type 1 and type 2 on sperm function. Front Endocrinol. 2018;9:268.

Article  Google Scholar 

Akarca Dizakar SÖ, Saribas GS, Tekcan A. Effects of ellagic acid in the testes of streptozotocin induced diabetic rats. Drug Chem Toxicol. 2022;45(5):2123–30.

Article  CAS  PubMed  Google Scholar 

Soylu H, Karacor K. The effects of hydroxytyrosol on Prdx6 and insulin expression in diabetic rat pancreases. Histochem Cell Biol. 2023;160(2):127–34.

Article  CAS  PubMed  Google Scholar 

Rodríguez-Morató J, Boronat A, Kotronoulas A, Pujadas M, Pastor A, Olesti E, de la Torre R. Metabolic disposition and biological significance of simple phenols of dietary origin: Hydroxytyrosol and tyrosol. Drug Metab Rev. 2016;48(2):218–36.

Article  PubMed  Google Scholar 

Fuccelli R, Fabiani R, Rosignoli P. Hydroxytyrosol exerts anti-inflammatory and anti-oxidant activities in a mouse model of systemic inflammation. Molecules. 2018;23(12):3212.

Article  PubMed  PubMed Central  Google Scholar 

Echeverría F, Ortiz M, Valenzuela R, Videla LA. Hydroxytyrosol and cytoprotection: A projection for clinical interventions. Int J Mol Sci. 2017;18(5):930.

Article  PubMed  PubMed Central  Google Scholar 

de las Hazas MCL, Godinho-Pereira J, Macià A, Almeida AF, Ventura MR, Motilva MJ, Santos CN. Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells. J Funct Foods. 2018;46:110–7.

Article  Google Scholar 

Kwan HY, Chao X, Su T, Fu X, Tse AKW, Fong WF, Yu ZL. The anticancer and antiobesity effects of Mediterranean diet. Crit Rev Food Sci Nutr. 2017;57(1):82–94.

Article  CAS  PubMed  Google Scholar 

Alsemeh AE, Samak MA, El-Fatah SSA. Therapeutic prospects of hydroxytyrosol on experimentally induced diabetic testicular damage: potential interplay with AMPK expression. Cell Tissue Res. 2020;380:173–89.

Article  CAS  PubMed  Google Scholar 

Sadeghirad M, Soleimanzadeh A, Shalizar-Jalali A, Behfar M. Synergistic protective effects of 3, 4-dihydroxyphenylglycol and hydroxytyrosol in male rats against induced heat stress-induced reproduction damage. Food Chem Toxicol. 2024;190:114818.

Article  CAS  PubMed  Google Scholar 

Sasaki K, Iwai K. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Immunol Rev. 2015;266(1):175–89.

Article  CAS  PubMed  Google Scholar 

Aksentijevich I, Zhou Q. NF-κB pathway in autoinflammatory diseases: dysregulation of protein modifications by ubiquitin defines a new category of autoinflammatory diseases. Front Immunol. 2017;8:399.

Article  PubMed  PubMed Central  Google Scholar 

Kaya S, Yalcın T. In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics. Cell Stress Chaperones. 2023;28(6):811–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keusekotten K, Elliott PR, Glockner L, Fiil BK, Damgaard RB, Kulathu Y, Komander D. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell. 2013;153(6):1312–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caballero-Oteyza A, Crisponi L, Peng XP, Wang H, Mrovecova P, Olla S, Proietti M. OTULIN-related conditions: report of a new case and review of the literature using GenIA. Clin Immunol. 2024;265:110292.

Yalcın T, Kaya S, Kuloğlu T. Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model. Toxicol Mech Methods. 2024;34(1):98–108.

Article  PubMed  Google Scholar 

Wang Q, Wang L, Botchway BO, Zhang Y, Huang M, Liu X. OTULIN can improve spinal cord injury by the NF-κB and Wnt/β-catenin signaling pathways. Mol Neurobiol. 2024;61(11):8820–8830.

Zheng H, Hu Y, Shao M, Chen S, Qi S. Chromium picolinate protects against testicular damage in STZ-induced diabetic rats via anti-inflammation, anti-oxidation, inhibiting apoptosis, and regulating the TGF-β1/Smad pathway. Molecules. 2023;28(22):7669.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodriguez-Pérez MD, Santiago-Corral L, Ortega-Hombrados L, Verdugo C, Arrebola MM, Martín-Aurioles E, González-Correa JA. The effect of the extra virgin olive oil minor phenolic compound 3′, 4′-dihydroxyphenylglycol in experimental diabetic kidney disease. Nutrients. 2023;15(2):377.

Article  PubMed  PubMed Central  Google Scholar 

Yalçın T, Kaya S. The effect of hydroxytyrosol on spexin immunoreactivity in pancreatic islets and serum insulin levels in a Streptozotocin-induced experimental diabetes model in rats. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2024;13(1):28–33.

Article  Google Scholar 

Johnsen SG. Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormone Res Paediatrics. 1970;1(1):2–25.

Article  CAS  Google Scholar 

Yalçın T, Kaya S. Therapeutic potential of the linalool against cadmium-induced testicular tissue damage. J Trace Elem Med Biol. 2024;84:127455.

Article  PubMed  Google Scholar 

Kaya S, Yalçın T, Kuloğlu T. Resveratrol may reduce oxidative stress and apoptosis in doxorubicin-induced cardiotoxicity by regulating meteorin-like and TRPM2 levels. Comp Clin Pathol. 2023;32(3):393–404.

Article  CAS  Google Scholar 

Yalçın T, Kaya S. Thymoquinone may alleviate cisplatin-induced muscle atrophy in rats by regulating mitofusin 2 and meteorin-like levels. Comp Clin Pathol. 2023;32(3):339–45.

Article  Google Scholar 

Kaya S, Yalcın T, Tektemur A, Kuloğlu T. N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury. Cell Stress Chaperones. 2023;28(6):849–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karagüzel E, Kutlu Ö, Yuluğ E, Mungan S, Kazaz İO, Tok DS, Özgür GK. Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. J Pediatr Surg. 2012;47(9):1716–23.

Article  PubMed  Google Scholar 

Yalçın T, Kaya S, Kuloğlu T, Yiğin A. N-acetylcysteine may regulate altered meteorin-like levels in testicular tissue due to aluminum exposure. Biol Trace Elem Res. 2023;201(11):5335–45.

Article  PubMed  Google Scholar 

Memişoğulları R. Diyabette serbest radikallerin rolü ve antioksidanların etkisi. Duzce Med J. 2005;7(3):30–9.

Google Scholar 

Yigitturk G, et al. The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes. Biomed Pharmacother. 2017;87:240–6.

Article  CAS  PubMed  Google Scholar 

Zhao Y, Song W, Wang Z, Wang Z, Jin X, Xu J, Cai L. Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation. Redox Biol. 2018;14:609–17.

Article  CAS  PubMed  Google Scholar 

Khalil ASM, Giribabu N, Yelumalai S, Shahzad H, Kilari EK, Salleh N. Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats. Life Sci. 2021;278:119605.

Comments (0)

No login
gif