Baloglu FK, Tas DG, Yilmaz O, Severcan F. The recovery effect of Vitamin C on structural alterations due to Streptozotocin-Induced diabetes in rat testicular tissues. Spectrochim Acta Part A Mol Biomol Spectrosc. 2023;288:122149.
He Z, Yin G, Li QQ, Zeng Q, Duan J. Diabetes mellitus causes male reproductive dysfunction: A review of the evidence and mechanisms. vivo. 2021;35(5):2503–11.
Sampannang A, Arun S, Burawat J, Sukhorum W, Iamsaard S. Testicular histopathology and phosphorylated protein changes in mice with diabetes induced by multiple-low doses of streptozotocin: An experimental study. Int J Reproductive Biomed. 2018;16(4):235.
Nna VU, Abu Bakar AB, Ahmad A, Eleazu CO, Mohamed M. Oxidative stress, NF-κb-mediated inflammation and apoptosis in the testes of streptozotocin–induced diabetic rats: Combined protective effects of malaysian propolis and metformin. Antioxidants. 2019;8(10):465.
Article PubMed PubMed Central Google Scholar
Condorelli RA, La Vignera S, Mongioì LM, Alamo A, Calogero AE. Diabetes mellitus and infertility: different pathophysiological effects in type 1 and type 2 on sperm function. Front Endocrinol. 2018;9:268.
Akarca Dizakar SÖ, Saribas GS, Tekcan A. Effects of ellagic acid in the testes of streptozotocin induced diabetic rats. Drug Chem Toxicol. 2022;45(5):2123–30.
Article CAS PubMed Google Scholar
Soylu H, Karacor K. The effects of hydroxytyrosol on Prdx6 and insulin expression in diabetic rat pancreases. Histochem Cell Biol. 2023;160(2):127–34.
Article CAS PubMed Google Scholar
Rodríguez-Morató J, Boronat A, Kotronoulas A, Pujadas M, Pastor A, Olesti E, de la Torre R. Metabolic disposition and biological significance of simple phenols of dietary origin: Hydroxytyrosol and tyrosol. Drug Metab Rev. 2016;48(2):218–36.
Fuccelli R, Fabiani R, Rosignoli P. Hydroxytyrosol exerts anti-inflammatory and anti-oxidant activities in a mouse model of systemic inflammation. Molecules. 2018;23(12):3212.
Article PubMed PubMed Central Google Scholar
Echeverría F, Ortiz M, Valenzuela R, Videla LA. Hydroxytyrosol and cytoprotection: A projection for clinical interventions. Int J Mol Sci. 2017;18(5):930.
Article PubMed PubMed Central Google Scholar
de las Hazas MCL, Godinho-Pereira J, Macià A, Almeida AF, Ventura MR, Motilva MJ, Santos CN. Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells. J Funct Foods. 2018;46:110–7.
Kwan HY, Chao X, Su T, Fu X, Tse AKW, Fong WF, Yu ZL. The anticancer and antiobesity effects of Mediterranean diet. Crit Rev Food Sci Nutr. 2017;57(1):82–94.
Article CAS PubMed Google Scholar
Alsemeh AE, Samak MA, El-Fatah SSA. Therapeutic prospects of hydroxytyrosol on experimentally induced diabetic testicular damage: potential interplay with AMPK expression. Cell Tissue Res. 2020;380:173–89.
Article CAS PubMed Google Scholar
Sadeghirad M, Soleimanzadeh A, Shalizar-Jalali A, Behfar M. Synergistic protective effects of 3, 4-dihydroxyphenylglycol and hydroxytyrosol in male rats against induced heat stress-induced reproduction damage. Food Chem Toxicol. 2024;190:114818.
Article CAS PubMed Google Scholar
Sasaki K, Iwai K. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Immunol Rev. 2015;266(1):175–89.
Article CAS PubMed Google Scholar
Aksentijevich I, Zhou Q. NF-κB pathway in autoinflammatory diseases: dysregulation of protein modifications by ubiquitin defines a new category of autoinflammatory diseases. Front Immunol. 2017;8:399.
Article PubMed PubMed Central Google Scholar
Kaya S, Yalcın T. In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics. Cell Stress Chaperones. 2023;28(6):811–20.
Article CAS PubMed PubMed Central Google Scholar
Keusekotten K, Elliott PR, Glockner L, Fiil BK, Damgaard RB, Kulathu Y, Komander D. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell. 2013;153(6):1312–26.
Article CAS PubMed PubMed Central Google Scholar
Caballero-Oteyza A, Crisponi L, Peng XP, Wang H, Mrovecova P, Olla S, Proietti M. OTULIN-related conditions: report of a new case and review of the literature using GenIA. Clin Immunol. 2024;265:110292.
Yalcın T, Kaya S, Kuloğlu T. Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model. Toxicol Mech Methods. 2024;34(1):98–108.
Wang Q, Wang L, Botchway BO, Zhang Y, Huang M, Liu X. OTULIN can improve spinal cord injury by the NF-κB and Wnt/β-catenin signaling pathways. Mol Neurobiol. 2024;61(11):8820–8830.
Zheng H, Hu Y, Shao M, Chen S, Qi S. Chromium picolinate protects against testicular damage in STZ-induced diabetic rats via anti-inflammation, anti-oxidation, inhibiting apoptosis, and regulating the TGF-β1/Smad pathway. Molecules. 2023;28(22):7669.
Article CAS PubMed PubMed Central Google Scholar
Rodriguez-Pérez MD, Santiago-Corral L, Ortega-Hombrados L, Verdugo C, Arrebola MM, Martín-Aurioles E, González-Correa JA. The effect of the extra virgin olive oil minor phenolic compound 3′, 4′-dihydroxyphenylglycol in experimental diabetic kidney disease. Nutrients. 2023;15(2):377.
Article PubMed PubMed Central Google Scholar
Yalçın T, Kaya S. The effect of hydroxytyrosol on spexin immunoreactivity in pancreatic islets and serum insulin levels in a Streptozotocin-induced experimental diabetes model in rats. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2024;13(1):28–33.
Johnsen SG. Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormone Res Paediatrics. 1970;1(1):2–25.
Yalçın T, Kaya S. Therapeutic potential of the linalool against cadmium-induced testicular tissue damage. J Trace Elem Med Biol. 2024;84:127455.
Kaya S, Yalçın T, Kuloğlu T. Resveratrol may reduce oxidative stress and apoptosis in doxorubicin-induced cardiotoxicity by regulating meteorin-like and TRPM2 levels. Comp Clin Pathol. 2023;32(3):393–404.
Yalçın T, Kaya S. Thymoquinone may alleviate cisplatin-induced muscle atrophy in rats by regulating mitofusin 2 and meteorin-like levels. Comp Clin Pathol. 2023;32(3):339–45.
Kaya S, Yalcın T, Tektemur A, Kuloğlu T. N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury. Cell Stress Chaperones. 2023;28(6):849–59.
Article CAS PubMed PubMed Central Google Scholar
Karagüzel E, Kutlu Ö, Yuluğ E, Mungan S, Kazaz İO, Tok DS, Özgür GK. Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. J Pediatr Surg. 2012;47(9):1716–23.
Yalçın T, Kaya S, Kuloğlu T, Yiğin A. N-acetylcysteine may regulate altered meteorin-like levels in testicular tissue due to aluminum exposure. Biol Trace Elem Res. 2023;201(11):5335–45.
Memişoğulları R. Diyabette serbest radikallerin rolü ve antioksidanların etkisi. Duzce Med J. 2005;7(3):30–9.
Yigitturk G, et al. The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes. Biomed Pharmacother. 2017;87:240–6.
Article CAS PubMed Google Scholar
Zhao Y, Song W, Wang Z, Wang Z, Jin X, Xu J, Cai L. Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation. Redox Biol. 2018;14:609–17.
Article CAS PubMed Google Scholar
Khalil ASM, Giribabu N, Yelumalai S, Shahzad H, Kilari EK, Salleh N. Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats. Life Sci. 2021;278:119605.
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