Li M, Cao S, Xu RH. Global trends and epidemiological shifts in gastrointestinal cancers: insights from the past four decades. Cancer Commun (Lond). 2025;45:774–88. https://doi.org/10.1002/cac2.70017.
Kalff MC, Wagner AD, Verhoeven RH, et al. Sex differences in tumor characteristics, treatment, and outcomes of gastric and esophageal cancer surgery: nationwide cohort data from the Dutch upper GI cancer audit. Gastric Cancer. 2022;25:22–32.
Lou L, Wang L, Zhang Y, et al. Sex difference in incidence of gastric cancer: an international comparative study based on the Global Burden of Disease Study 2017. BMJ Open. 2020;10:e033323.
Article PubMed PubMed Central Google Scholar
Xing Y, Hosaka H, Moki F, et al. Gender differences in patients with gastric adenocarcinoma. J Clin Med. 2024;13:2524.
Article PubMed PubMed Central Google Scholar
Pala L, De Pas T, Conforti F. Under-representation of women in Randomized Clinical Trials testing anticancer immunotherapy may undermine female patients care. A call to action. Semin Oncol. 2022;49:400–4. https://doi.org/10.1053/j.seminoncol.2022.09.004.
Wang S, Zheng R, Li J, et al. Global, regional, and national lifetime risks of developing and dying from gastrointestinal cancers in 185 countries: a population-based systematic analysis of GLOBOCAN. Lancet Gastroenterol Hepatol. 2024;9:229–37.
Article PubMed PubMed Central CAS Google Scholar
Gong YQ, Lu CJ, Xiao YR, et al. Epidemiological trends of early-onset gastrointestinal cancers from 1990 to 2021 and predictions for 2036: analysis from the global burden of disease study 2021. Ann Med. 2025;57:2555518.
Article PubMed PubMed Central Google Scholar
Waldmann E, Jiricka L, Zessner-Spitzenberg J, et al. Differences between men and women with respect to colorectal cancer mortality despite screening colonoscopy. Gastrointest Endosc. 2024;99:998–1005.e2.
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.
Gan X, Dai G, Li Y, Xu L, Liu G. Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review. Cancer Biol Med. 2024;21:898–915.
Cook MB, Dawsey SM, Freedman ND, et al. Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev. 2009;18:1174–82.
Article PubMed PubMed Central Google Scholar
Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P. Cancer incidence estimates for 2022 & projection for 2025: Result from National Cancer Registry Programme. India. Indian J Med Res. 2022;156:598–607.
National Cancer Registry Programme Investigator Group, Mathur P, Sathishkumar K, et al. Cancer incidence and mortality across 43 cancer registries in India. JAMA Netw Open. 2025;8:e2527805. https://doi.org/10.1001/jamanetworkopen.2025.27805.
McGlynn K, Sahasrabuddhe V, Campbell P, et al. Reproductive factors, exogenous hormone use and risk of hepatocellular carcinoma among US women: results from the Liver Cancer Pooling Project. Br J Cancer. 2015;112:1266–72.
Article PubMed PubMed Central CAS Google Scholar
Ferlay J, Ervik M, Lam F, et al. Global cancer observatory: Cancer today. Lyon: International Agency for Research on Cancer; 2020. https://gco.iarc.fr/today
Ferlay J, Ervik M, Lam F, et al. Global cancer observatory: cancer today (version 1.1). Lyon: International Agency for Research on Cancer; 2024. https://gco.iarc.who.int/today
Kim SE, Paik HY, Yoon H, Lee JE, Kim N, Sung MK. Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol. 2015;21:5167–75.
Stabellini N, Chandar AK, Chak A, et al. Sex differences in esophageal cancer overall and by histological subtype. Sci Rep. 2022;12:5248.
Article PubMed PubMed Central CAS Google Scholar
Chen CF, Chang HC. Time trend and age-specific gender difference in the incidence of liver cancer from 2009 to 2018 in Taiwan. Adv Dig Med. 2023;10:135-42.
Liu Y, Zheng J, Hao J, et al. Global burden of primary liver cancer by five etiologies and global prediction by 2035 based on global burden of disease study 2019. Cancer Med. 2022;11:1310–23.
Article PubMed PubMed Central CAS Google Scholar
Zhang X, El-Serag HB, Thrift AP. Sex and race disparities in the incidence of hepatocellular carcinoma in the United States examined through age–period–cohort analysis. Cancer Epidemiol Biomarkers Prev. 2020;29:88–94.
Wong MC, Jiang JY, Goggins WB, et al. International incidence and mortality trends of liver cancer: a global profile. Sci Rep. 2017;7:45846.
Article PubMed PubMed Central CAS Google Scholar
Wu EM, Wong LL, Hernandez BY, et al. Gender differences in hepatocellular cancer: disparities in nonalcoholic fatty liver disease/steatohepatitis and liver transplantation. Hepatoma Res. 2018;4:66.
Article PubMed PubMed Central Google Scholar
Pijnappel EN, Schuurman M, Wagner AD, et al. Sex, gender and age differences in treatment allocation and survival of patients with metastatic pancreatic cancer: A nationwide study. Front Oncol. 2022;24:839779. https://doi.org/10.3389/fonc.2022.839779.
Hohla F, Hopfinger G, Romeder F, et al. Female gender may predict response to FOLFIRINOX in patients with unresectable pancreatic cancer: a single institution retrospective review. Int J Oncol. 2013;44:319–26.
Gaddam S, Abboud Y, Oh J, et al. Incidence of pancreatic cancer by age and sex in the US, 2000-2018. JAMA. 2021;326:2075–7.
Article PubMed PubMed Central Google Scholar
Grahovac J, Đurić A, Tanić M, Krivokuća A. Sex-related differences in pancreatic ductal adenocarcinoma progression and response to therapy. Int J Mol Sci. 2024;25:12669.
Article PubMed PubMed Central CAS Google Scholar
Are C, Ahmad H, Ravipati A, et al. Global epidemiological trends and variations in the burden of gallbladder cancer. J Surg Oncol. 2017;115:580–90.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.
Zahm SH, Fraumeni JF Jr. Racial, ethnic, and gender variations in cancer risk: considerations for future epidemiologic research. Environ Health Perspect. 1995;103Suppl 8:283–6.
Edgren G, Liang L, Adami HO, Chang ET. Enigmatic sex disparities in cancer incidence. Eur J Epidemiol. 2012;27:187–96.
Jackson SS, Marks MA, Katki HA, et al. Sex disparities in the incidence of 21 cancer types: Quantification of the contribution of risk factors. Cancer. 2022;128:3531–40.
Haupt S, Caramia F, Klein SL, Rubin JB, Haupt Y. Sex disparities matter in cancer development and therapy. Nat Rev Cancer. 2021;21:393–407.
Dorak MT, Karpuzoglu E. Gender differences in cancer susceptibility: an inadequately addressed issue. Front Genet. 2012;3:268.
Article PubMed PubMed Central Google Scholar
Marino P, Mininni M, Deiana G, et al. Healthy lifestyle and cancer risk: Modifiable risk factors to prevent cancer. Nutrients. 2024;16:800.
GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1223–49.
Thomasson HR. Gender differences in alcohol metabolism. Physiological responses to ethanol. Recent Dev Alcohol. 1995;12:163–79.
Rumgay H, Murphy N, Ferrari P, Soerjomataram I. Alcohol and cancer: epidemiology and biological mechanisms. Nutrients. 2021;13:3173.
Article PubMed PubMed Central CAS Google Scholar
Scherübl H. Tobacco smoking and gastrointestinal cancer risk. Visc Med. 2022;38:217–22.
Article PubMed PubMed Central Google Scholar
Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB, Maisonneuve P. Smoking and colorectal cancer: a meta-analysis. JAMA. 2008;300:2765–78.
Iodice S, Gandini S, Maisonneuve P, Lowenfels AB. Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg. 2008;393:535–45.
Prabhu A, Obi KO, Rubenstein JH. The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis. Am J Gastroenterol. 2014;109:822–7.
Blechter B, Portengen L, Downward G, et al. Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China. Environ Int. 2025;205:109889. https://doi.org/10.1016/j.envint.2025.109889.
Article PubMed PubMed Central CAS Google Scholar
Shridhar K, Krishnatreya M, Kumar R, et al. Household cooking fuel and gallbladder cancer risk: a multi-centre case–control study in India. Cancer Causes Control. 2024;35:281–92.
Shridhar K, Krishnatreya M, Sarkar S, et al. Chronic exposure to drinking water arsenic and gallbladder cancer risk: Preliminary evidence from endemic regions of India. Cancer Epidemiol Biomarkers Prev. 2023;32:406–14.
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