Greer DM, Shemie SD, Lewis A, Torrance S, Varelas P, Goldenberg FD, et al. Determination of brain death/death by neurologic criteria: the World Brain Death Project. JAMA. 2020;324:1078–97.
Lewis A, Bakkar A, Kreiger-Benson E, Kumpfbeck A, Liebman J, Shemie SD, et al. Determination of death by neurologic criteria around the world. Neurology. 2020;95:e299–309.
Su YY, Chen WB, Liu G, Fan LL, Zhang Y, Ye H, et al. An investigation and suggestions for the improvement of brain death determination in China. Chin Med J (Engl). 2018;131:2910–4.
Brain Injury Evaluation Quality Control Center of National Health Commission; Neurocritical Care Committee of the Chinese Society of Neurology (NCC/CSN); Neurocritical Care Committee of China Neurologist Association (NCC/CNA). Criteria and practical guidance for determination of brain death in adults (2nd edition). Chin Med J (Engl). 2019;132:329–35.
Migdady I, Amin M, Shoskes A, Hassett C, Rae-Grant A, Snider SB, et al. Outcomes, time-trends, and factors associated with ancillary study use for the determination of brain death. Crit Care Med. 2021;49:e840–8.
Brain Injury Evaluation Quality Control Center of National Health Commission. Criteria and practical guidance for determination of brain death in children. Zhonghua Er Ke Za Zhi. 2019;57:331–5 (in Chinese).
Greer DM, Kirschen MP, Lewis A, Gronseth GS, Rae-Grant A, Ashwal S, et al. Pediatric and adult brain death/death by neurologic criteria consensus guideline. Neurology. 2023;101:1112–32.
Article PubMed PubMed Central Google Scholar
Shemie SD, Wilson LC, Hornby L, Basmaji J, Baker AJ, Bensimon CM, et al. A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline. Can J Anesth/Journal canadien d’anesthésie. 2023;70:483–557.
Hoffmann O, Tempel H, Wolf S, Gratopp A, Salih F. Loss of cerebral blood flow and cerebral perfusion pressure in brain death: a transcranial Duplex ultrasonography study. J Crit Care. 2022;71:154091.
Michimoto I, Miyashita K, Suzuyama H, Yano K, Kobayashi Y, Saito K, et al. Simulation study on the effects of cancellous bone structure in the skull on ultrasonic wave propagation. Sci Rep. 2021;11:17592.
Article CAS PubMed PubMed Central Google Scholar
Bode H, Wais U. Age dependence of flow velocities in basal cerebral arteries. Arch Dis Child. 1988;63:606–11.
Article CAS PubMed PubMed Central Google Scholar
Lewis A, Liebman J, Kreiger-Benson E, Kumpfbeck A, Bakkar A, Shemie SD, et al. Ancillary testing for determination of death by neurologic criteria around the world. Neurocrit Care. 2021;34:473–84.
Chang JJ, Tsivgoulis G, Katsanos AH, Malkoff MD, Alexandrov AV. Diagnostic accuracy of transcranial Doppler for brain death confirmation: systematic review and meta-analysis. AJNR Am J Neuroradiol. 2016;37:408–14.
Article CAS PubMed PubMed Central Google Scholar
Bode H, Sauer M, Pringsheim W. Diagnosis of brain death by transcranial Doppler sonography. Arch Dis Child. 1988;63:1474–8.
Article CAS PubMed PubMed Central Google Scholar
Qian SY, Fan XM, Yin HH. Transcranial Doppler assessment of brain death in children. Singap Med J. 1998;39:247–50.
Wei X. The application value of TCD combined with 24 h VEEG in the diagnosis of brain death in children. J Med Forum. 2021;42:142–4, f3 (in Chinese).
Ekici B, Ersayoğlu İ, Yazıcı Özkaya P, Cebeci K, Koç G, Eda Turanlı E. Impact of decompressive craniectomy on diagnosing brain death in children. Turk Arch Pediatr. 2024;59:93–7.
Article PubMed PubMed Central Google Scholar
Mataya L, Ross LF, Ghavam A, Paquette ET. Pediatric intensivist and pediatric neurologist perspectives and practices on death by neurologic criteria. J Clin Ethics. 2021;32:195–205.
Article PubMed PubMed Central Google Scholar
Francoeur C, Weiss MJ, MacDonald JM, Press C, Greer DM, Berg RA, et al. Variability in pediatric brain death determination protocols in the United States. Neurology. 2021;97:e310–9.
Singh Y, Tissot C, Fraga MV, Yousef N, Cortes RG, Lopez J, et al. International evidence-based guidelines on point of care ultrasound (POCUS) for critically ill neonates and children issued by the POCUS working group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). Crit Care. 2020;24:65.
Article PubMed PubMed Central Google Scholar
Figueroa LV, Kaltenbach GH, Tassin ME, Cárdenas MM. Survey on the use and practice of transcranial Doppler ultrasound in neurocritical patients in pediatric intensive care units in Argentina. Arch Argent Pediatr. 2022;120:415–9.
Westphal GA, Veiga VC, Franke CA. Diagnosis of brain death in Brazil. Rev Bras Ter Intensiva. 2019;31:403–9.
Article PubMed PubMed Central Google Scholar
Núñez AR, Blanco AP. National recommendations on pediatric donation. Anales de Pediatría (Engl Ed). 2020;93:134.e1–9.
Arsava EM, Demirkaya Ş, Dora B, Giray S, Gökçe M, Güler A, et al. Turkish neurological society diagnostic guidelines for brain death. Turk J Neurol. 2014;20:101–4.
Australian and New Zealand Intensive Care Society (ANZICS). The Australian and New Zealand Intensive Care Society statement on death and organ donation (edition 4.1). Melbourne: ANZICS; 2021.
Orban JC, Ferret E, Jambou P, Ichai C, AzuRéa Group. Confirmation of brain death diagnosis: a study on French practice. Anaesth Crit Care Pain Med. 2015;34:145–50.
Segura T, Calleja S, Irimia P, Tembl JI, Spanish Society of Neurosonology. Recommendations for the use of transcranial Doppler ultrasonography to determine the existence of cerebral circulatory arrest as diagnostic support for brain death. Rev Neurosci. 2009;20:251–9.
Consensus Group on Transcranial Doppler in Diagnosis of Brain Death. Latin American consensus on the use of transcranial Doppler in the diagnosis of brain death. Rev Bras Ter Intensiva. 2014;26:240–52.
Health Council of the Netherlands. Determining death in postmortal organ donation-protocols and criteria, including an updated brain death protocol. The Hague: Health Council of the Netherlands; 2015 (in Dutch).
Tomek A, Školoudík D, Škoda O, Neumann J, Šaňák D, Mikulík R, et al. Protocol for the determination of brain death using transcranial sonography, developed by the Neurosonology Committee and the Cerebrovascular Section of the Czech Neurological Society of the Czech Medical Association (ČLS JEP). 2016. https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2016-5-4/metodika-stanoveni-smrti-mozku-pomoci-transkranialni-sonografie-vypracovana-neurosonologickou-komisi-a-cerebrovaskularni-sekci-ceske-neurologicke-spolecnosti-cls-jep-59150. Accessed 5 Jul 2025 (in Czech).
Parliament of the Czech Republic. Act No. 44/2013 Coll., amending Act No. 285/2002 Coll., on the donation, procurement and transplantation of tissues and organs and on amendments to certain acts (the Transplantation Act), as amended, and other related acts. 2013. https://www.zakonyprolidi.cz/cs/2013-44. Accessed 5 Jul 2025 (in Czech).
Lange MC, Zétola VH, Miranda-Alves M, Moro CH, Silvado CE, Rodrigues DL, et al. Brazilian guidelines for the application of transcranial ultrasound as a diagnostic test for the confirmation of brain death. Arq Neuropsiquiatr. 2012;70:373–80.
Federal Council of Medicine (CFM). Resolution CFM no. 2173, dated November 23, 2017. Defines the criteria for the diagnosis of brain death. 2017. https://sistemas.cfm.org.br/normas/visualizar/resolucoes/BR/2017/2173. Accessed 5 Jul 2025 (in Portuguese).
Swiss Academy Of Medical Sciences. Medical-ethical guidelines: determination of death with regard to organ transplantation and preparations for organ removal. Swiss Med Wkly. 2018;148:w14524.
Article CAS PubMed Google Scholar
Secretariat of Health Government, Ministry of Health and Social Development. National protocol for the determination of the irreversible cessation of brain functions (certification of death). 2019. https://www.boletinoficial.gob.ar/detalleAviso/primera/206448/20190429. Accessed 5 Jul 2025 (in Spanish).
Minister of Health. The procedure and criteria for determining the permanent and irreversible cessation of brain function. 2020. https://monitorpolski.gov.pl/MP/rok/2020/pozycja/73. Accessed 5 Jul 2025 (in Polish).
Bundesärztekammer. Guideline pursuant to § 16 para. 1 sentence 1 no. 1 TPG on the rules for determining death according to § 3 para. 1 sentence 1 no. 2 TPG and the procedural rules for determining the permanent, irreversible cessation of the total function of the cerebrum, cerebellum, and brainstem according to § 3 para. 2 no. 2 TPG, fifth revision. 2022. https://www.wbbaek.de/richtlinien-leitlinien/irreversibler-hirnfunktionsausfall. Accessed 5 Jul 2025 (in German).
Health Austria Ltd. Recommendations for the determination of death due to irreversible cessation of brain function with preserved circulation (“brain death diagnostic recommendations”). 2025. https://transplant.goeg.at/todesfeststellung. Accessed 5 Jul 2025 (in German).
Marinoni M, Trapani S, Cianchi G. Transcranial Doppler confirming of brain death in patients treated with venoarterial extracorporeal membrane oxygenation. ASAIO J. 2020;66:e65.
Brain Injury Evaluation Quality Control Centre of National Health and Family Planning Commission. Criteria and practical guidance for determination of brain death in children (BQCC version). Chin Med J (Engl). 2014;127:4140–4.
Academy of Medical Royal Colleges. A code of practice for the diagnosis and confirmation of death: 2025 update. 2025. https://www.aomrc.org.uk/publication-category/reports-and-guidance. Accessed 5 Jul 2025.
McMenamin JB, Volpe JJ. Doppler ultrasonography in the determination of neonatal brain death. Ann Neurol. 1983;14:302–7.
Article CAS PubMed Google Scholar
Kirkham FJ, Levin SD, Padayachee TS, Kyme MC, Neville BG, Gosling RG. Transcranial pulsed Doppler ultrasound findings in brain stem death. J Neurol Neurosurg Psychiatry. 1987;50:1504–13.
Article CAS PubMed PubMed Central Google Scholar
Glasier CM, Seibert JJ, Chadduck WM, Williamson SL, Leithiser RE Jr. Brain death in infants: evaluation with Doppler US. Radiology. 1989;172:377–80.
Article CAS PubMed Google Scholar
Powers AD, Graeber MC, Smith RR. Transcranial Doppler ultrasonography in the determination of brain death. Neurosurgery. 1989;24:884–9.
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