Hepcidin-25 as a Diagnostic and Oxidative Stress-Linked Biomarker in Pediatric with Early Iron Deficiency

Piskin E, Cianciosi D, Gulec S, Tomas M, Capanoglu E. Iron absorption: factors, limitations, and improvement methods. ACS Omega. 2022;7:20441–56. https://doi.org/10.1021/acsomega.2c01833.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Woźniak D, Podgórski T, Krzyżanowska-Jankowska P, Dobrzyńska M, Wichłacz-Trojanowska N, Przysławski J, et al. The influence of intensive nutritional education on the iron status in infants. Nutrients. 2022;14. https://doi.org/10.3390/nu14122453.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armitage AE, Moretti D. The importance of iron status for young children in low- and middle-income countries: a narrative review. Pharmaceuticals. 2019;12. https://doi.org/10.3390/ph12020059.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pasricha S-R, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. Lancet. 2021;397:233–48. https://doi.org/10.1016/S0140-6736(20)32594-0.

Article  CAS  PubMed  Google Scholar 

Georgieff MK. Iron deficiency in pregnancy. Am J Obstet Gynecol. 2020;223:516–24. https://doi.org/10.1016/j.ajog.2020.03.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar SB, Arnipalli SR, Mehta P, Carrau S, Ziouzenkova O. Iron deficiency anemia: efficacy and limitations of nutritional and comprehensive mitigation strategies. Nutrients. 2022. https://doi.org/10.3390/nu14142976.

Article  PubMed  PubMed Central  Google Scholar 

Armishty F, Mohammed L, Ibrahim R, Haji I, Omar A, Jameel D, et al. The prevalence of anemia and associated factors among children under 5 years in Zakho City, Kurdistan Region, Iraq. Passer Journal of Basic and Applied Sciences. 2023;5:391–7. https://doi.org/10.24271/psr.2023.390463.1287.

Article  Google Scholar 

Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ. Iron deficiency anaemia: pathophysiology, assessment, practical management. BMJ Open Gastroenterol. 2022;9. https://doi.org/10.1136/bmjgast-2021-000759.

Article  PubMed  PubMed Central  Google Scholar 

Owaidah T, Al-Numair N, Al-Suliman A, Zolaly M, Hasanato R, Al Zahrani F, et al. Iron deficiency and iron deficiency anemia are common epidemiological conditions in Saudi Arabia: report of the national epidemiological survey. Anemia. 2020;2020:1–8. https://doi.org/10.1155/2020/6642568.

Article  CAS  Google Scholar 

Prentice AM, Bah A, Jallow MW, Jallow AT, Sanyang S, Sise EA, et al. Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children. Sci Adv. 2019. https://doi.org/10.1126/sciadv.aav9020.

Article  PubMed  PubMed Central  Google Scholar 

Camaschella C. Iron deficiency. Blood. 2019;133:30–9. https://doi.org/10.1182/blood-2018-05-815944.

Article  CAS  PubMed  Google Scholar 

Gedfie S, Getawa S, Melku M. Prevalence and associated factors of iron deficiency and iron deficiency anemia among under-5 children: a systematic review and meta-analysis. Glob Pediatr Health. 2022;9. https://doi.org/10.1177/2333794X221110860.

Article  Google Scholar 

Banerjee S, Katiyar P, Kumar L, Kumar V, Saini SS, Krishnan V, et al. Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway. Free Radic Biol Med. 2021;168:189–202. https://doi.org/10.1016/j.freeradbiomed.2021.03.019.

Article  CAS  PubMed  Google Scholar 

Ginzburg YZ. Hepcidin and its multiple partners: Complex regulation of iron metabolism in health and disease 2023:249–84. https://doi.org/10.1016/bs.vh.2023.03.001.

Fillebeen C, Charlebois E, Wagner J, Katsarou A, Mui J, Vali H, et al. Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Blood. 2019;133:344–55. https://doi.org/10.1182/blood-2018-05-850404.

Article  CAS  PubMed  Google Scholar 

Kowdley KV, Gochanour EM, Sundaram V, Shah RA, Handa P. Hepcidin signaling in health and disease: ironing out the details. Hepatol Commun. 2021;5:723–35. https://doi.org/10.1002/hep4.1717.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nemeth E, Ganz T. Hepcidin-ferroportin interaction controls systemic iron homeostasis. Int J Mol Sci. 2021;22. https://doi.org/10.3390/ijms22126493.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dignass A, Farrag K, Stein J. Limitations of serum ferritin in diagnosing iron deficiency in inflammatory conditions. Int J Chronic Dis. 2018;2018:1–11. https://doi.org/10.1155/2018/9394060.

Article  Google Scholar 

Orrico F, Laurance S, Lopez AC, Lefevre SD, Thomson L, Möller MN, et al. Oxidative stress in healthy and pathological red blood cells. Biomolecules. 2023;13. https://doi.org/10.3390/biom13081262.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jewad AM, Albakaa AAH, Khalaf WS, Shwayel AJ. Impact of iron supplementation on the state of oxidative stress in pregnant women suffering from iron-deficient anemia. J Appl Hematol. 2024;15:197–203. https://doi.org/10.4103/joah.joah_61_24.

Article  Google Scholar 

Allameh A, Niayesh-Mehr R, Aliarab A, Sebastiani G, Pantopoulos K. Oxidative stress in liver pathophysiology and disease. Antioxidants. 2023. https://doi.org/10.3390/antiox12091653.

Article  PubMed  PubMed Central  Google Scholar 

Moscheo C, Licciardello M, Samperi P, La Spina M, Di Cataldo A, Russo G. New insights into iron deficiency anemia in children: a practical review. Metabolites. 2022;12. https://doi.org/10.3390/metabo12040289.

Article  CAS  PubMed  PubMed Central  Google Scholar 

N R. Iron Metabolism. Tietz Textb. Lab. Med. Seventh Ed, Saunders; 2022, p. 1865–1891.

Halwachs-Baumann G. Diagnosis of anaemia: old things rearranged. Wien Med Wochenschr. 2012;162:478–88. https://doi.org/10.1007/s10354-012-0149-1.

Article  PubMed  Google Scholar 

Hadwan MH, Abed HN. Data supporting the spectrophotometric method for the estimation of catalase activity. Data Brief. 2016;6:194–9. https://doi.org/10.1016/j.dib.2015.12.012.

Article  PubMed  Google Scholar 

El-Asheer OM, Naeem MS, Abdel-Hafez FA, Abdou MAA, Mohamed KA. Iron deficiency in preschool non-anemic Egyptian children. Egypt Pediatr Assoc Gaz. 2021;69. https://doi.org/10.1186/s43054-021-00081-z.

Article  Google Scholar 

Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811–9. https://doi.org/10.1074/jbc.M008923200.

Article  CAS  PubMed  Google Scholar 

Babaei M, Shafiei S, Bijani A, Heidari B, Hosseyni SR, Vakili Sadeghi M. Ability of serum ferritin to diagnose iron deficiency anemia in an elderly cohort. Rev Bras Hematol Hemoter. 2017;39:223–8. https://doi.org/10.1016/j.bjhh.2017.02.002.

Article  PubMed  PubMed Central  Google Scholar 

Uijterschout L, Domellöf M, Berglund SK, Abbink M, Vos P, Rövekamp L, et al. Serum hepcidin in infants born after 32 to 37 wk of gestational age. Pediatr Res. 2016;79:608–13. https://doi.org/10.1038/pr.2015.258.

Article  CAS  PubMed  Google Scholar 

Dewan P, Dixit A, Gomber S, Kotru M, Banerjee BD, Tyagi V, et al. Serum and urinary hepcidin for diagnosing iron-deficiency anemia in under-5 children. J Pediatr Hematol Oncol. 2019;41:e216–20. https://doi.org/10.1097/MPH.0000000000001320.

Article  CAS  PubMed  Google Scholar 

Ganz T. Hepcidin and the global burden of iron deficiency. Clin Chem. 2015;61:577–8.

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