Grasso G, Torregrossa F. The impact of cerebrospinal fluid shunting on quality of life in idiopathic normal pressure hydrocephalus: a long-term analysis. Neurosurg Focus. 2023;54(4):E7. https://doi.org/10.3171/2023.1.Focus22643.
Luciano M, Holubkov R, Williams MA, et al. Placebo-controlled effectiveness of idiopathic normal pressure hydrocephalus shunting: a randomized pilot trial. Neurosurgery. 2023;92(3):481–9. https://doi.org/10.1227/neu.0000000000002225.
Kazui H, Miyajima M, Mori E, Ishikawa M. Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial. Lancet Neurol. 2015;14(6):585–94. https://doi.org/10.1016/s1474-4422(15)00046-0.
Hereitová I, Griffa A, Allali G, Dorňák T. Gait characteristics in idiopathic normal pressure hydrocephalus: a review on the effects of CSF tap test and shunt surgery. Eur J Med Res. 2024;29(1):633. https://doi.org/10.1186/s40001-024-02162-2.
Article PubMed Central PubMed Google Scholar
Wikkelsø C, Hellström P, Klinge PM, Tans JT. The European iNPH multicentre study on the predictive values of resistance to CSF outflow and the CSF tap test in patients with idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 2013;84(5):562–8. https://doi.org/10.1136/jnnp-2012-303314.
Petersen J, Hellström P, Wikkelsø C, Lundgren-Nilsson A. Improvement in social function and health-related quality of life after shunt surgery for idiopathic normal-pressure hydrocephalus. J Neurosurg. 2014;121(4):776–84. https://doi.org/10.3171/2014.6.Jns132003.
Ishii K, Kanda T, Harada A, et al. Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus. Eur Radiol. 2008;18(11):2678–83. https://doi.org/10.1007/s00330-008-1044-4.
Neikter J, Agerskov S, Hellström P, et al. Ventricular volume is more strongly associated with clinical improvement than the Evans index after shunting in idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2020;41(7):1187–92. https://doi.org/10.3174/ajnr.A6620.
Article CAS PubMed Central PubMed Google Scholar
Thavarajasingam SG, El-Khatib M, Vemulapalli K, et al. Radiological predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. Acta Neurochir (Wien). 2023;165(2):369–419. https://doi.org/10.1007/s00701-022-05402-8.
Wu D, Moghekar A, Shi W, Blitz AM, Mori S. Systematic volumetric analysis predicts response to CSF drainage and outcome to shunt surgery in idiopathic normal pressure hydrocephalus. Eur Radiol. 2021;31(7):4972–80. https://doi.org/10.1007/s00330-020-07531-z.
Article PubMed Central PubMed Google Scholar
Bradley WG Jr. CSF flow in the brain in the context of normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2015;36(5):831–8. https://doi.org/10.3174/ajnr.A4124.
Article CAS PubMed Google Scholar
MacAulay N, Keep RF, Zeuthen T. Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited. Fluids Barriers CNS. 2022;19(1):26. https://doi.org/10.1186/s12987-022-00323-1.
Article PubMed Central PubMed Google Scholar
Hattori T, Ito K, Aoki S, et al. White matter alteration in idiopathic normal pressure hydrocephalus: tract-based spatial statistics study. AJNR Am J Neuroradiol. 2012;33(1):97–103. https://doi.org/10.3174/ajnr.A2706.
Article CAS PubMed Google Scholar
Sarica A, Quattrone A, Mechelli A, Vaccaro MG, Morelli M, Quattrone A. Corticospinal tract abnormalities and ventricular dilatation: a transdiagnostic comparative tractography study. NeuroImage: Clinical. 2021;32:102862. https://doi.org/10.1016/j.nicl.2021.102862.
Article PubMed Central PubMed Google Scholar
Lotan E, Damadian BE, Rusinek H, et al. Quantitative imaging features predict spinal tap response in normal pressure hydrocephalus. Neuroradiology. 2022;64(3):473–81. https://doi.org/10.1007/s00234-021-02782-z.
Laticevschi T, Lingenberg A, Armand S, Griffa A, Assal F, Allali G. Can the radiological scale “iNPH Radscale” predict tap test response in idiopathic normal pressure hydrocephalus? J Neurol Sci. 2021;420:117239. https://doi.org/10.1016/j.jns.2020.117239.
Shentu W, Kong Q, Zhang Y, et al. Functional abnormalities of the glymphatic system in cognitive disorders. Neural Regen Res. 2025;20(12):3430–47. https://doi.org/10.4103/nrr.Nrr-d-24-01049.
Article CAS PubMed Central PubMed Google Scholar
Choi JD, Moon Y, Kim HJ, Yim Y, Lee S, Moon WJ. Choroid plexus volume and permeability at brain MRI within the Alzheimer disease clinical spectrum. Radiology. 2022;304(3):635–45. https://doi.org/10.1148/radiol.212400.
Jiang J, Zhuo Z, Wang A, et al. Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum. Alzheimers Res Ther. 2024;16(1):149. https://doi.org/10.1186/s13195-024-01520-w.
Article CAS PubMed Central PubMed Google Scholar
Dhawan SS, Hacein-Bey L, Massoud TF. Choroid plexus enlargement in idiopathic normal pressure hydrocephalus and concept proposal for noninvasive volume-reductive therapies. Brain Res. 2025;1857:149593. https://doi.org/10.1016/j.brainres.2025.149593.
Article CAS PubMed Google Scholar
Nakajima M, Yamada S, Miyajima M, et al. Guidelines for management of idiopathic normal pressure hydrocephalus (Third Edition): endorsed by the Japanese Society of Normal Pressure Hydrocephalus. Neurol Med Chir (Tokyo). 2021;61(2):63–97. https://doi.org/10.2176/nmc.st.2020-0292.
Article PubMed Central PubMed Google Scholar
Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98. https://doi.org/10.1016/0022-3956(75)90026-6.
Article CAS PubMed Google Scholar
Podsiadlo D, Richardson S. The timed up & go: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–8. https://doi.org/10.1111/j.1532-5415.1991.tb01616.x.
Article CAS PubMed Google Scholar
Löfgren N, Berglund L, Giedraitis V, et al. Extracted step parameters during the timed up and go test discriminate between groups with different levels of cognitive ability-a cross-sectional study. BMC Geriatr. 2025;25(1):182. https://doi.org/10.1186/s12877-025-05828-6.
Article PubMed Central PubMed Google Scholar
Agathos CP, Velisar A, Shanidze NM. A Comparison of Walking Behavior during the Instrumented TUG and Habitual Gait. Sensors. 2023. https://doi.org/10.3390/s23167261.
Article PubMed Central PubMed Google Scholar
Sundström N, Rydja J, Virhammar J, Kollén L, Lundin F, Tullberg M. The timed up and go test in idiopathic normal pressure hydrocephalus: a nationwide study of 1300 patients. Fluids Barriers CNS. 2022;19(1):4. https://doi.org/10.1186/s12987-021-00298-5.
Article CAS PubMed Central PubMed Google Scholar
Nicolosi S, Todisco M, Paoletti M, et al. Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus. Front Aging Neurosci. 2025;17:1554642. https://doi.org/10.3389/fnagi.2025.1554642.
Article PubMed Central PubMed Google Scholar
Huntley JD, Gould RL, Liu K, Smith M, Howard RJ. Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression. BMJ Open. 2015;5(4):e005247. https://doi.org/10.1136/bmjopen-2014-005247.
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