Leptin-specific epigenetic modulation of preterm cord blood serves as a candidate biomarker for obesity

Harris, R. B. S. Direct and indirect effects of leptin on adipocyte metabolism. Biochim. Biophys. Acta (BBA) Mol. Basis Dis. 1842, 414–423 (2014).

Article  CAS  Google Scholar 

Palhinha, L. et al. Leptin induces proadipogenic and proinflammatory signaling in adipocytes. Front. Endocrinol. 10, 1–15 (2019).

Article  Google Scholar 

Picó, C., Palou, M., Pomar, C. A., Rodríguez, A. M. & Palou, A. Leptin as a key regulator of the adipose organ. Rev. Endocr. Metab. Disord. 23, 13–30 (2022).

Article  PubMed  Google Scholar 

Salem, H., Rosenfeld, T., Altarescu, G., Grisaru-Granovsky, S. & Birk, R. Maternal and neonatal leptin and leptin receptor polymorphisms associated with preterm birth. Gene 591, 209–213 (2016).

Article  CAS  PubMed  Google Scholar 

Fonseca, V. M., Sichieri, R., Moreira, M. E. & Moura, A. S. Early postnatal growth in preterm infants and cord blood leptin. J. Perinatol. Off. J. Calif. Perinat. Assoc. 24, 751–756 (2004).

CAS  Google Scholar 

Jornayvaz, F. R. et al. Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the colaus study. Cardiovasc. Diabetol. 15, 73 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Casirati, A. et al. Preterm birth and metabolic implications on later life: a narrative review focused on body composition. Front. Nutr. 9, 1–15 (2022).

Article  Google Scholar 

Piyasena, C. et al. Dynamic changes in DNA methylation occur during the first year of life in preterm infants. Front. Endocrinol. 7, 158 (2016).

Iikuni, N., Lam, Q. L., Lu, L., Matarese, G. & La Cava, A. Leptin and Inflammation. Curr. Immunol. Rev. 4, 70–79 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, C. & Li, X. Role of leptin and adiponectin in immune response and inflammation. Int. Immunopharmacol. 161, 115082 (2025).

Article  CAS  PubMed  Google Scholar 

Khwanchuea, R. & Punsawad, C. Associations between body composition, leptin, and vitamin D varied by the body fat percentage in adolescents. Front. Endocrinol. 13, 876231 (2022).

Hwang, C. S., Loftus, T. M., Mandrup, S. & Lane, M. D. Adipocyte differentiation and leptin expression. Annu. Rev. Cell Dev. Biol. 13, 231–259 (1997).

Article  CAS  PubMed  Google Scholar 

Steinbrekera, B. et al. Origins of neonatal leptin deficiency in preterm infants. Pediatr. Res. 85, 1016–1023 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Kadakia, R. et al. Association of cord blood methylation with neonatal leptin: an epigenome wide association study. PLoS ONE 14, e0226555 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mantzoros, C. S. et al. Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study. Pediatrics 123, 682–689 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Tan, K. et al. Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution. Int. J. Obes. 46, 637–645 (2022).

Article  CAS  Google Scholar 

Ong, K. K. et al. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. alspac study team. avon longitudinal study of pregnancy and childhood. J. Clin. Endocrinol. Metab. 84, 1145–1148 (1999).

Article  CAS  PubMed  Google Scholar 

Herman, J. G., Graff, J. R., Myöhänen, S., Nelkin, B. D. & Baylin, S. B. Methylation-specific PCR: a novel pcr assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93, 9821–9826 (1996).

Article  CAS  PubMed  PubMed Central  Google Scholar 

García-Cardona, M. C. et al. DNA methylation of leptin and adiponectin promoters in children is reduced by the combined presence of obesity and insulin resistance. Int. J. Obes. 38, 1457–1465 (2014).

Article  Google Scholar 

Srinivas, V. et al. Maternal N-3 PUFAs deficiency alters uterine artery remodeling and placental epigenome in the mice. J. Nutr. Biochem 96, 108784–108796 (2021).

Article  CAS  PubMed  Google Scholar 

Nogues, P. et al. Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta. Clin. Epigenet. 11, 20 (2019).

Article  Google Scholar 

Jeanrenaud, B. & Rohner-Jeanrenaud, F. Effects of neuropeptides and leptin on nutrient partitioning: dysregulations in obesity. Annu. Rev. Med. 52, 339–351 (2001).

Article  CAS  PubMed  Google Scholar 

Saladin, R. et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527–528 (1995).

Article  CAS  PubMed  Google Scholar 

Fried, S. K., Ricci, M. R., Russell, C. D. & Laferrère, B. Regulation of leptin production in humans. J. Nutr. 130, 3127S–3131S (2000).

Article  CAS  PubMed  Google Scholar 

Lee, M.-J. et al. Acute and chronic regulation of leptin synthesis, storage, and secretion by insulin and dexamethasone in human adipose tissue. Am. J. Physiol. Endocrinol. Metab. 292, E858–E864 (2007).

Article  CAS  PubMed  Google Scholar 

DeLacey, S. et al. Leptin and adiposity measures from birth to later childhood: findings from the hyperglycemia and adverse pregnancy outcomes follow-up study. Pediatr. Obes. 19, e13087 (2024).

Article  PubMed  Google Scholar 

Kadakia, R., Ma, M. & Josefson, J. Neonatal adiposity increases with rising cord blood IGF-1 levels. Clin. Endocrinol. 85, 70–75 (2016).

Li, P. et al. Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: a prospective cohort study. Front. Endocrinol. 13, 1030216 (2022).

Article  Google Scholar 

Martos-Moreno, G. A. et al. Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism. Eur. J. Endocrinol. 161, 381–389 (2009).

Article  CAS  PubMed  Google Scholar 

Chiesa, C. et al. Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: Is there a relationship with fetal growth and neonatal anthropometry? Clin. Chem. 54, 550–558 (2008).

Article  CAS  PubMed  Google Scholar 

Beghini, M. et al. Serum Igf1 and linear growth in children with congenital leptin deficiency before and after leptin substitution. Int. J. Obes. 45, 1448–1456 (2021).

Article  CAS  Google Scholar 

Rustogi, D., Yadav, S., Ramji, S. & Mishra, T. K. Growth patterns in small for gestational age babies and correlation with insulin-like growth factor-1 levels. Indian Pediatr. 55, 975–978 (2018).

Article  PubMed  Google Scholar 

Gruzdeva, O., Borodkina, D., Uchasova, E., Dyleva, Y. & Barbarash, O. Leptin resistance: underlying mechanisms and diagnosis. Diab. Metab. Syndr. Obes. 12, 191–198 (2019).

Article  CAS  Google Scholar 

Liu, J., Lai, F., Hou, Y. & Zheng, R. Leptin signaling and leptin resistance. Med. Rev. 2, 363–384 (2022).

Article  Google Scholar 

Martin, S. S., Qasim, A. & Reilly, M. P. Leptin resistance. J. Am. Coll. Cardiol. 52, 1201–1210 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maffei, M. et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med 1, 1155–1161 (1995).

Article  CAS  PubMed  Google Scholar 

Lappas, M., Permezel, M. & Rice, G. E. Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-Κb, peroxisomal proliferator-activated receptor-γ and extracellularly regulated kinase 1/2. Endocrinology 146, 3334–3342 (2005).

Article  CAS 

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