DiMeglio, L. A., Evans-Molina, C. & Oram, R. A. Type 1 diabetes. Lancet 391, 2449–2462 (2018).
Article PubMed PubMed Central Google Scholar
Lam, C. J. et al. β-cell mass in type 1 diabetes: A decade of progress. Curr. Opin. Endocrinol. Diab Obes. 26, 19–27 (2019).
International Diabetes Federation. IDF Diabetes Atlas 11th ed. (International Diabetes Federation, 2023).
Al-Kazraj, N. H., Al-Shammaree, S. A. W. & Al-Janabi, J. M. Epidemiology of type 1 diabetes mellitus among children in Iraq: A systematic review and meta-analysis. Diab Res. Clin. Pract. 172, 108636 (2021).
Khan, M. A. et al. Epidemiology of type 1 diabetes - A systematic review of country-level data from the Middle East and North Africa region. Clin. Epidemiol. 12, 989–1007 (2020).
Robertson, C. C. et al. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat. Genet. 53, 962–971 (2021).
Article CAS PubMed PubMed Central Google Scholar
Jacobsen, L. M. et al. Immune mechanisms and pathways targeted in type 1 diabetes. Curr. Diab Rep. 20, 1–11 (2020).
Atkinson, M. A., Campbell-Thompson, M., Kusmartseva, I. & Kaestner, K. H. Organization of the human pancreas in health and disease. Diabetologia 65, 932–942 (2022).
Chen, Y. G., Cabrera, S. M. & Dickson, B. M. Molecular profiles of islet inflammation associated with progression to type 1 diabetes. Diabetes 70, 1760–1772 (2021).
Coppieters, K. T. et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J. Exp. Med. 209, 51–60 (2012).
Article CAS PubMed PubMed Central Google Scholar
Zoka, A. et al. Altered immune regulation in type 1 diabetes. Clin. Dev. Immunol. 2019, 1–10 (2019).
Fatima, N. et al. Role of pro-inflammatory cytokines and biochemical markers in the pathogenesis of type 1 diabetes: Correlation with age and glycemic condition in diabetic human subjects. PLoS One 15, e0228006 (2020).
Abdullah, M. et al. Role of inflammatory cytokines in pathogenesis of type 1 diabetes: A review of current evidence. Clin. Exp. Immunol. 205, 30–41 (2021).
Alnek, K. et al. Increased blood levels of growth factors, proinflammatory cytokines, and Th17 cytokines in patients with newly diagnosed type 1 diabetes. PLoS One 15, e0233737 (2020).
Carlos, D. et al. The Th17 pathway in type 1 diabetes: Mechanisms and therapeutic perspectives. Front. Immunol. 12, 721955 (2021).
Mahmoud, F. et al. Elevated concentrations of interleukins IL-17 and IL-23 in type 1 diabetes mellitus: A study in patients from Kuwait. Immunol. Lett. 226, 22–29 (2020).
Zatterale, F. et al. Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes. Front. Physiol. 10, 1607 (2020).
Article PubMed PubMed Central Google Scholar
Rigby, M. R. et al. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diab Endocrinol. 1, 284–294 (2013).
Quattrin, T. et al. Golimumab and beta-cell function in youth with new-onset type 1 diabetes. N. Engl. J. Med. 383, 2007–2017 (2020).
Article CAS PubMed Google Scholar
Rigby, M. R. et al. Two-year follow-up from the T1GER study: Continued off-therapy metabolic improvements in children and young adults with new-onset T1D treated with golimumab and characterization of responders. Diab Care 46, 561–569 (2023).
Moran, A. et al. Interleukin-1 antagonism in type 1 diabetes of recent onset: Two multicentre, randomised, double-blind, placebo-controlled trials. Lancet 381, 1905–1915 (2013).
Article CAS PubMed PubMed Central Google Scholar
Hahn, M., Ghanbari, M. & van Meurs, J. B. The role of DNA methylation in the development of type 1 diabetes. Clin. Epigenetics 13, 1–15 (2021).
Li, Y. Y. et al. Role of gut microbiota in type 1 diabetes and its treatment. J. Diab Investig. 12, 1794–1806 (2021).
Abdulrazzaq, A. M., Al-Gazally, M. E. & Alkafaji, H. M. Assessment of serum IL-17 and IL-10 levels in children and adolescents with type 1 diabetes mellitus. Med. J. Babylon. 16, 136–140 (2019).
Ahmed, S. A., Raouf, M. & Al-Shammary, A. M. IL-17A, IL-21, and TGF-β levels in Iraqi patients with type 1 diabetes mellitus: Association with disease parameters. J. Diab Res. 2020, 3958456 (2020).
Ali, R. M., Al-Mayah, Q. S. & Jebur, M. S. Genetic variants in IL-6 and IL-10 genes and susceptibility to type 1 diabetes mellitus in Iraqi children. Meta Gene 26, 100784 (2020).
Al-Yasiri, I. K., Zghair, K. H. & Al-Sharifi, L. M. Interleukin-6 gene polymorphism is associated with increased risk of type 1 diabetes mellitus in Iraqi children. Gene Rep. 17, 100523 (2019).
American Diabetes Association Classification and diagnosis of diabetes: Standards of medical care in diabetes-2023. Diab Care 46, S19–S40 (2023).
Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2^(-ΔΔCT) method. Methods 25, 402–408 (2001).
Article CAS PubMed Google Scholar
Bellini, S. et al. Immunometabolic modulation of immune cells in type 1 diabetes: Novel insights and therapeutic perspectives. Biomedicines 12, 395 (2024).
D’Agostino, S., Valentini, G. & Dolci, M. Exploring interleukin levels in type 1 diabetes and periodontitis: A review with a focus on childhood. Child. (Basel) 11, 238 (2024).
Skyler, J. S. et al. Differentiation of diabetes by pathophysiology, natural history, and prognosis. Diabetes 71, 698–707 (2022).
Al-Shuwaikh, A. M., Abdul-Hassan, I. A. & Al-Tu’ma, F. J. Association of interleukin-6 and interleukin-10 gene polymorphisms with type 1 diabetes mellitus in Iraqi children. Meta Gene 29, 100904 (2021).
Kumar, L., Gupta, A. & Kumar, N. Association of interleukin-10 (-1082A>G) gene polymorphism with the risk of type 1 diabetes in Asian population: A meta-analysis. Cytokine 124, 154569 (2019).
Zhang, S., Wang, Q., Zhao, H. & Peng, X. Influence of the interleukin-17A gene polymorphism on susceptibility to type 1 diabetes mellitus. Diab Res. Clin. Pract. 168, 108370 (2020).
Hassan, M. M. et al. Circulating CXCL10 and IL-17 in relation to insulin requirements in children with type 1 diabetes mellitus. J. Pediatr. Endocrinol. Metab. 34, 101–107 (2021).
Katsarou, A. et al. Predictors of development of type 1 diabetes in children with islet autoimmunity: A population-based and registry study. Diab Care 45, 1327–1336 (2022).
Mubarak, A. et al. Association of cytokines gene polymorphisms with type 1 diabetes mellitus in Saudi children. PeerJ 8, e9358 (2020).
Fuhrman, C. A. et al. Quantitative profiling of immune cells in type 1 diabetes using mass cytometry. Diabetologia 64, 1599–1612 (2021).
Fathi, R. A. et al. Environmental pollution by depleted uranium in Iraq with special reference to Mosul and possible effects on cancer and birth defect rates. Med. Confl. Surviv. 29, 7–25 (2013).
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