Breaking fungal biofilms and multidrug resistance using intelligent ciclopirox-based nanotechnology: Design and experimental validation

Al-Nuaimi, B. N. (2024). Evaluation of susceptibility of Candida species to six antifungal drugs in Iraqi specimens. Journal of Communicable Diseases, 56(2), 53–61.

Anselmo, A. C., & Mitragotri, S. (2019). Nanoparticles in the clinic: An update. Bioengineering and Translational Medicine, 4(3), e10143.

Arendrup, M. C., & Patterson, T. F. (2017). Multidrug-resistant Candida: Epidemiology, molecular mechanisms, and treatment. The Journal of Infectious Diseases, 216(S3), S445–S451.

Baptista, P. V., McCusker, M. P., Carvalho, A., Ferreira, D. A., Mohan, N. M., Martins, M., & Fernandes, A. R. (2018). Nano-strategies to fight multidrug resistant bacteria – “A battle of the titans.” Frontiers in Microbiology, 9, 1441.

Bongomin, F., Gago, S., Oladele, R., & Denning, D. (2017). Global and multi-national prevalence of fungal diseases – estimate precision. Journal of Fungi, 3(4), 57.

Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012). Hidden killers: Human fungal infections. Science Translational Medicine, 4(165), 13.

Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., & Mozafari, M. R. (2018). Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics, 10(2), 57.

Denning, D. W. (2024). Global incidence and mortality of severe fungal disease. The Lancet Infectious Diseases, 24(7), e428–e438.

Domb, A. J., Sharifzadeh, G., Nahum, V., & Hosseinkhani, H. (2021). Safety evaluation of nanotechnology products. Pharmaceutics, 13(10), 1615.

Ghaima, K. K., Kamal, I. M. A., & Mohammed, A. A. (2020). Prevalence and molecular identification of Candida spp. isolated from vulvovaginitis in Baghdad, Iraq. Journal of Disease and Global Health, 13(1), 21–27.

Gholami-Shabani, M., Shams-Ghahfarokhi, M., Jamzivarl, F., & Razzaghi-Abyaneh, M. (2023). Fungal biofilms in nanotechnology era diagnosis, drug delivery, and treatment strategies. In: Gholami-Shabani, M., Shams-Ghahfarokhi, M., Jamzivarl, F., & Razzaghi-Abyaneh, M. (Eds.). Myconanotechnology. CRC Press, Boca Raton. Pp. 129–168.

Khalaf, H. Y., Noomi, B. S., Aiub, M. M., Mohammed, A. Y., & Aifa, S. (2025). Incidence and characterization of Candida species belonging to Iraqi hospitalized patients. Access Microbiology, in press.

Li, J., & Mooney, D. J. (2016). Designing hydrogels for controlled drug delivery. Nature Reviews Materials, 1, 16071.

Lohse, M. B., Gulati, M., Johnson, A. D., & Nobile, C. J. (2017). Development and regulation of single- and multi-species Candida albicans biofilms. Nature Reviews Microbiology, 16(1), 19–31.

Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024). Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions. Signal Transduction and Targeted Therapy, 9, 166.

Mohammad, K. A., Ismail, H. M., Shekhany, K. A. M., Yashooa, R. K., Younus, D. A., Abdullah, S. K., Alatraqchi, A. A. F., Aldabbagh, R., & Denning, D. W. (2024). Fungal disease incidence and prevalence in Iraq – Preliminary estimates. Journal of Medical Mycology, 34(4), 101516.

Mucha, P., Borkowski, B., Erkiert-Polguj, A., & Budzisz, E. (2024). Ciclopirox and ciclopirox olamine: Antifungal agents in dermatology with expanding therapeutic potential. Applied Sciences, 14(24), 11859.

Mura, S., Nicolas, J., & Couvreur, P. (2013). Stimuli-responsive nanocarriers for drug delivery. Nature Materials, 12(11), 991–1003.

Ostrowska-Czubenko, J., Gierszewska, M., & Pieróg, M. (2015). pH-responsive hydrogel membranes based on modified chitosan: Water transport and kinetics of swelling. Journal of Polymer Research, 22(8), 153.

Pelgrift, R. Y., & Friedman, A. J. (2013). Nanotechnology as a therapeutic tool to combat microbial resistance. Advanced Drug Delivery Reviews, 65(13–14), 1803–1815.

Peulen, T.-O., & Wilkinson, K. J. (2011). Diffusion of nanoparticles in a biofilm. Environmental Science and Technology, 45(8), 3367–3373.

Ramage, G., Kean, R., Rautemaa-Richardson, R., Williams, C., & Lopez-Ribot, J. L. (2025). Fungal biofilms in human health and disease. Nature Reviews Microbiology, 23(6), 355–370.

Rodríguez-Rodríguez, R., Carreón-Álvarez, C., Cruz-Medina, C. A., Knauth, P., López, Z., Fletes-Vargas, G., & Sahagún, M. R. (2025). A review of pH-responsive chitosan-based hydrogels for drug delivery applications. European Polymer Journal, 237, 114173.

Sonthalia, S., Agrawal, M., & Sehgal, V. (2019). Topical Ciclopirox olamine 1%: Revisiting a unique antifungal. Indian Dermatology Online Journal, 10(4), 481–485.

World Health Organization (2022). WHO fungal priority pathogens list to guide research, development and public health action. World Health Organization, Geneva.

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