Multitarget approach to babesiosis therapy: An in vitro study of therapeutic compounds

Arbon, D., Mach, J., Čadková, A., Sipkova, A., Stursa, J., Klanicová, K., Machado, M., Ganter, M., Levytska, V., Sojka, D., Truksa, J., Werner, L., & Sutak, R. (2024). Chelation of mitochondrial iron as an antiparasitic strategy. ACS Infectious Diseases, 10(2), 676–687.

Bloch, E. M., Tonnetti, L., & Krause, P. J. (2021). Preventing transfusion-transmitted babesiosis. Pathogens, 10(9), 1176.

Bock, R. E., Jackson, L. A., de Vos, A. J., & Jorgensen, W. K. (2008). Babesiosis of cattle. In: Bowman, A. J., & Nuttall, P. A. (Eds.). Ticks: Biology, disease and control. Cambridge University Press. Pp. 281–307.

Cardillo, N. M., Villarino, N. F., Lacy, P. A., Doggett, J. S., Riscoe, M. K., Suarez, C. E., Ueti, M. W., & Chung, C. J. (2025). Enhanced anti-Babesia efficacy of buparvaquone and imidocarb when combined with ELQ-316 in vitro. Pharmaceuticals, 18(2), 218.

Carli, E., Trotta, M., Bordin, M., Caldin, M., & Solano-Gallego, L. (2025). Therapeutic approaches to canine babesiosis: Advances and challenges. Veterinary Parasitology, 325, 109122.

Ganz, T., & Nemeth, E. (2012). Iron metabolism: Interactions with normal and disordered erythropoiesis. Cold Spring Harbor Perspectives in Medicine, 2(5), a011668.

Gray, J. S., Estrada-Peña, A., & Zintl, A. (2019). Vectors of babesiosis. Annual Review of Entomology, 64, 149–165.

Guswanto, A., Sivakumar, T., Rizk, M. A., Elsayed, S. A. E., Youssef, M. A., Elsaid, E. E. S., Yokoyama, N., & Igarashi, I. (2014). Evaluation of a fluorescence-based method for antibabesial drug screening. Antimicrobial Agents and Chemotherapy, 58(8), 4713–4717.

Hildebrandt, A., Zintl, A., Montero, E., Hunfeld, K.-P., & Gray, J. (2021). Human babesiosis in Europe. Pathogens, 10(9), 165.

Jefferies, R., Ryan, U. M., Jardine, J., Robertson, I. D., & Irwin, P. J. (2007). Babesia gibsoni: Detection during experimental infections and after combined atovaquone and azithromycin therapy. Experimental Parasitology, 117(2), 115–123.

Korsinczky, M., McFadden, G. I., & Cowman, A. F. (2022). Advances in quinolone-based therapies against Babesia. Frontiers in Cellular and Infection Microbiology, 12, 874321.

Krause, P. J., Menon, S., Telford, S. R., Lantos, P. M., & Spielman, A. (2019). Human babesiosis. International Journal for Parasitology, 49(2), 165–176.

Lemieux, J. E., Tran, A. D., Freimark, L., Schaffner, S. F., Goethert, H., Andersen, K. G., & Rosenberg, E. (2016). A global map of genetic diversity in Babesia microti. PLoS One, 11(9), e0162892.

Lobo, C. A., Cursino-Santos, J. R., Alhassan, A., & Rodrigues, M. (2013). Babesia: An emerging infectious threat in transfusion medicine. PLoS Pathogens, 9(7), e1003387.

Munkhjargal, T., AbouLaila, M., Terkawi, M. A., Sivakumar, T., Ichikawa, M., Davaasuren, B., Nyamsuren, O., Batmagnai, E., Zhou, M., & Yokoyama, N. (2013). Development and optimization of a fluorescence-based assay for large-scale drug screening against Babesia parasites. Journal of Microbiological Methods, 93(2), 95–101.

Nguyen, T. T., Aboge, G. O., Terada, Y., Miyazaki, Y., Zulfiqar, M. F., & Xuan, X. (2019). Initiation of sexual stages of Babesia ovata under in vitro conditions and analysis using imaging flow cytometry. Pathogens, 8(3), 104.

Renard, I., & Ben Mamoun, C. (2021). Treatment of human babesiosis: Then and now. Pathogens, 10(9), 1120.

Rimal, S., Kumari Sah, R., Shakya, S., Acharya, M. M., & El-Dakhly, K. M. (2025). Bovine babesiosis: A clinical review. Mathews Journal of Veterinary Science, 9(5), 81.

Rizk, M. A., El-Sayed, S. A., Matter, R. M., Yokoyama, N., & Igarashi, I. (2016). Large-scale drug screening against Babesia divergens using a fluorescence-based high-throughput assay. Veterinary Parasitology, 220, 51–59.

Rizk, Y. S., Abbasi, I., Lieske, C., Dunford, M., & Ben Mamoun, C. (2015). Optimization of a fluorescence-based assay for large-scale drug screening against Babesia and Theileria parasites. PLoS One, 10(5), e0125276.

Simon, M. S., Westblade, L. F., Dziedziech, A., Visone, J. E., Furman, R. R., Jenkins, S. G., Schuetz, A. N., & Kirkman, L. A. (2017). Clinical and molecular evidence of atovaquone and azithromycin resistance in relapsed Babesia microti infection. Clinical Infectious Diseases, 65(7), 1222–1225.

Tuvshintulga, B., Sivakumar, T., Yokoyama, N., & Igarashi, I. (2019). Development of unstable resistance to diminazene aceturate in Babesia bovis. International Journal for Parasitology: Drugs and Drug Resistance, 9, 87–92.

Comments (0)

No login
gif