Hypolipidemic activity in a series of new hybrids of orotic acid and 1,2,4-triazole

Ballantyne, C. M., & Norata, G. D. (2025). The evolving landscape of targets for lipid lowering: From molecular mechanisms to translational implications. European Heart Journal, 46(44), 4737–4750.

Cao, R., Li, J., Sun, Y., Li, Y., Zhang, X.-L., Ding, H., & Liu, X.-W. (2025). Synthesis, characterization, and in vitro hypolipidemic mechanisms of sugar-SA triazole conjugates as potent pancreatic lipase inhibitors. Food Chemistry, 488, 144876.

Chhabria, M. T., Suhagia, B. N., Brahmkshatriya, P. S., & Raval, P. M. (2011). Synthesis and antihyperlipidemic activity of some novel 4-(substitutedamino)-5-substituted-3-mercapto-(4H)-1,2,4-triazoles. Arzneimittelforschung, 61(8), 452–457.

Cui, D., Yu, X., Guan, Q., Shen, Y., Liao, J., Liu, Y., & Su, Z. (2025). Cholesterol metabolism: Molecular mechanisms, biological functions, diseases, and therapeutic targets. Molecular Biomedicine, 6(1), 72.

Eberhardt, J., Santos-Martins, D., Tillack, A. F., & Forli, S. (2021). AutoDock Vina 1.2.0: New docking methods, expanded force field, and Python bindings. Journal of Chemical Information and Modeling, 61(8), 3891–3898.

Harden, K. K., & Robinson, J. L. (1984). Hypocholesteremia induced by orotic acid: Dietary effects and species specificity. Journal of Nutrition, 114(2), 411–421.

Idrees, G. A., Aly, O. M., Abuo-Rahma, G. E.-D. A., & Radwan, M. F. (2009). Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs. European Journal of Medicinal Chemistry, 44(10), 3973–3980.

Irshad, N., Khan, A. U., Shah, F. A., Nadeem, H., Ashraf, Z., Tipu, M. K., & Li, S. (2021). Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways. Fundamental and Clinical Pharmacology, 35(6), 1119–1132.

Jagtap, U. A., & Paul, A. T. (2025). Synthetic pancreatic lipase inhibitors in obesity treatment: Current updates on in silico design, synthesis, bioactivity, and SAR. RSC Medicinal Chemistry, 16, 5787–5842.

Karpenko, Y. V., Mykhailiuk, Y. O., Shmatenko, O. P., Solomennyi, A. M., Solomenna, O. O., Parchenko, V. V., & Kyrychko, B. P. (2025). Analgesic effectiveness of new 1,2,4-triazole derivatives in an experimental model of visceral pain: prospects for military medical application. Ukrainian Journal of Military Medicine, 6(4), 147–155.

Karpenko, Y., Gamze, T., Parchenko, V., Fadime Aydın, K., Ogloblina, M., Şuheda, Y., Bushuieva, I., Umit M., K., Khilkovets, A., & Burak, T. (2025). Cytotoxic potential of novel triazole-based hybrids: Design, synthesis, in silico evaluation, and in vitro assessment against cancer cell lines. Bioorganic Chemistry, 163, 108749.

Karpenko, Y., Medvedeva, K., Solomennyi, A., Rudenko, O., Panasenko, O., Parchenko, V., & Vasyuk, S. (2025). Design, synthesis, molecular docking, and antioxidant properties of a series of new S-derivatives of ((1,2,4-triazol-3(2H)-yl)methyl)thiopyrimidines. ScienceRise: Pharmaceutical Science, 53, 62–70.

Ma, L., Xie, C., Ran, Y., Liang, X., Huang, L., Pei, H., Chen, J., Liu, J., Sang, Y., Lai, H., Peng, A., Xiang, M., Wei, Y., & Chen, L. (2012). Synthesis and biological evaluation of 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione derivatives for the treatment of obesity-related nonalcoholic fatty liver disease. Journal of Medicinal Chemistry, 55(22), 9958–9972.

Ma, L., Xie, C., Ran, Y., Liang, X., Huang, L., Pei, H., Chen, J., Liu, J., Sang, Y., Lai, H., Peng, A., Xiang, M., Wei, Y., & Chen, L. (2012). Synthesis and biological evaluation of 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione derivatives for the treatment of obesity-related nonalcoholic fatty liver disease. Journal of Medicinal Chemistry, 55(22), 9958–9972.

Mahesh, T. C., Bhanubhai, N. S., Pathik, S. B., & Priyesha, M. R. (2011). Synthesis and antihyperlipidemic activity of some novel 4-(substitutedamino)-5-substituted-3-mercapto-(4H)-1,2,4-triazoles. Arzneimittelforschung, 61(8), 452–457.

Martin, A., Lang, S., Goeser, T., Demir, M., Steffen, H. M., & Kasper, P. (2022). Management of dyslipidemia in patients with non-alcoholic fatty liver disease. Current Atherosclerosis Reports, 24(7), 533–546.

Ohloblina, M. V., Bushuieva, I. V., & Parchenko, V. V. (2022). Analysis of the domestic market of 1,2,4-triazole-containing drugs. Current Issues in Pharmacy and Medicine: Science and Practice, 15(2), 215–222.

Parchenko, V. V., Panasenko, O. I., Karpenko, Y. V., Kyrychko, B. P., Zvenihorodska, T. V., Bigdan, O. A., Samura, T. O., Nahorna, N. O., Mykhailiuk, Y. O., Romanina, D. M., Gutyj, B. V., & Martynyshyn, V. P. (2024). Сontent of 1,2,4-triazole derivatives in cow’s milk, meat samples and animal organs after administration. Regulatory Mechanisms in Biosystems, 15(4), 830–836.

Siegel, P. M., Katzmann, J. L., Weinmann-Menke, J., Landmesser, U., Schunkert, H., Baldus, S., Böhm, M., Laufs, U., Lüscher, T. F., & Hilgendorf, I. (2026). A practical guide to the management of dyslipidaemia. Clinical Research in Cardiology, 115(2), 185–197.

Subramaniyan, V., & Hanim, Y. U. (2025). Role of pancreatic lipase inhibition in obesity treatment: Mechanisms and challenges towards current insights and future directions. International Journal of Obesity, 49(3), 492–506.

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