AGEs derived from high-sugar diets induce functional impairment of odontogenic stem cells via RAGE-mediated endoplasmic reticulum stress

Bernabé E, Ballantyne H, Longbottom C, Pitts NB (2020) Early introduction of sugar-sweetened beverages and caries trajectories from age 12 to 48 months. J Dent Res 99(8):898–906

Article  PubMed  PubMed Central  Google Scholar 

Cheever VJ, Mohajeri A, Patel K, Burris RC, Hung M (2025) Impact of free sugar consumption on dental caries: a cross-sectional analysis of children in the United States. Dent J (Basel) 13(2):48

Article  PubMed  PubMed Central  Google Scholar 

Feldens CA, Pinheiro LL, Cury JA et al (2022) Added sugar and oral health: a position paper of the Brazilian Academy of Dentistry. Front Oral Health 3:869112

Article  PubMed  PubMed Central  Google Scholar 

Guo R, Yu JH (2022) Multipotency and immunomodulatory benefits of stem cells from human exfoliated deciduous teeth. Front Dent Med 3:874896

Article  Google Scholar 

Hetz C (2012) The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13(2):89–102

Article  CAS  PubMed  Google Scholar 

Hudson BI, Lippman ME (2018) Targeting RAGE signaling in inflammatory disease. Annu Rev Med 69:349–364

Article  CAS  PubMed  Google Scholar 

Jiang T, Huang M, Jiang T et al (2020) Stem cell aging is linked to the cell’s redox state. Curr Stem Cell Res Ther 15(8):695–703

Google Scholar 

Kume S, Kato S, Yamagishi SI et al (2005) Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. J Bone Miner Res 20(9):1647–1658

Article  CAS  PubMed  Google Scholar 

Lechowska K, Wojtyla L, Quinet M, Kubala S, Lutts S, Garnczarska M (2021) Endogenous polyamines and ethylene biosynthesis in relation to germination of osmoprimed Brassica napus seeds under salt stress. Int J Mol Sci 23(1):349

Article  PubMed  PubMed Central  Google Scholar 

Lin YC, Li YJ, Rui YF, Dai GC, Teng GJ (2017) The effects of high glucose on tendon-derived stem cells: implications of the pathogenesis of diabetic tendon disorders. Oncotarget 8(11):17518–17528

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Huang K, Cai GY et al (2014) Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling. Cell Signal 26(1):110–121

Article  PubMed  Google Scholar 

Liu Y, Cheng J, Wan LJ, Chen W (2022) Total and added sugar intakes are increasing among children and adolescents in China: findings from CHNS 1997–2011. Nutrients 14(16):3340

Article  PubMed  PubMed Central  Google Scholar 

Meng J, Ma X, Wang N et al (2015) Activation of GLP-1 receptor promotes bone marrow stromal cell osteogenic differentiation through β-Catenin. Stem Cell Rep 4(4):579–591

Article  Google Scholar 

Miura M, Gronthos S, Zhao MR et al (2003) SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 100(10):5807–5812

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moores CJ, Kelly SAM, Moynihan PJ (2022) Systematic review of the effect on caries of sugars intake: ten-year update. J Dent Res 101(9):1034–1045

Article  CAS  PubMed  Google Scholar 

Nor NHM, Mansor NI, Kashim M, Mokhtar MH, Hatta FAM (2023) From teeth to therapy: a review of therapeutic potential within the secretome of stem cells from human exfoliated deciduous teeth. Int J Mol Sci 24(14):11763

Article  Google Scholar 

Ogen-Shtern N, Ben David T, Lederkremer GZ (2016) Protein aggregation and ER stress. Brain Res 1648(Pt B):658–666

Article  CAS  PubMed  Google Scholar 

Senatus LM, Schmidt AM (2017) The AGE-RAGE axis: implications for age-associated arterial diseases. Front Genet 8:187

Article  PubMed  PubMed Central  Google Scholar 

Tang QY, Markby GR, MacNair AJ et al (2023) TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease. Cell Prolif 56(6):e13435

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tobón-Velasco JC, Cuevas E, Torres-Ramos MA (2014) Receptor for AGEs (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress. CNS Neurol Disord Drug Targets 13(9):1615–1626

Article  PubMed  Google Scholar 

Wan XQ, Zhang H, Tian JF et al (2024) The cGAS-STING/PERK-eIF2α: individual or potentially collaborative signaling transduction in cardiovascular diseases. Int J Biol Sci 20(15):5868–5887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu KS, Zhang L, Yu N et al (2023) Effects of advanced glycation end products (AGEs) on the differentiation potential of primary stem cells: a systematic review. Stem Cell Res Ther 14(1):74

Article  PubMed  PubMed Central  Google Scholar 

Yang P, Shen WB, Albert Reece E, Chen X, Yang P (2016) High glucose suppresses embryonic stem cell differentiation into neural lineage cells. Biochem Biophys Res Commun. https://doi.org/10.1016/j.bbrc.2016.02.117

Article  PubMed  PubMed Central  Google Scholar 

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