ER stress affects proliferation and induces polyploidization of cultured human HaCaT and A431 cells

Abhari BA, McCarthy N, Le Berre M, Kilcoyne M, Joshi L, Agostinis P, Fulda S (2019) Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress. Cell Death Dis 10:155. https://doi.org/10.1038/s41419-019-1381-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adams J, Palombella VJ, Sausville EA, Johnson J, Destree A, Lazarus DD, Maas J, Pien CS, Prakash S, Elliott PJ (1999) Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 59:2615–2622

CAS  PubMed  Google Scholar 

Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, Leuzzi B, Luís A, McCarthy N, Montibeller L, More S, Papaioannou A, Püschel F, Sassano ML, Skoko J, Agostinis P, de Belleroche J, Eriksson LA, Fulda S, Gorman AM, Healy S, Kozlov A, Muñoz-Pinedo C, Rehm M, Chevet E, Samali A (2019) Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. FEBS J 286:241–278. https://doi.org/10.1111/febs.14608

Article  CAS  PubMed  Google Scholar 

Baek HA, Kim DS, Park HS, Jang KY, Kang MJ, Lee DG, Moon WS, Chae HJ, Chung MJ (2012) Involvement of endoplasmic reticulum stress in myofibroblastic differentiation of lung fibroblasts. Am J Respir Cell Mol Biol 46:731–739. https://doi.org/10.1165/rcmb.2011-0121OC

Article  CAS  PubMed  Google Scholar 

Banerjee DK, Seijo Lebrón A, Baksi K (2022) Glycotherapy: a new paradigm in breast cancer research. Biomolecules 12:487. https://doi.org/10.3390/biom12040487

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bavi P, Uddin S, Ahmed M, Jehan Z, Bu R, Abubaker J, Sultana M, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Prabhakaran S, Hussain AR, Al-Kuraya KS (2011) Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma. Am J Pathol 178:2109–2120. https://doi.org/10.1016/j.ajpath.2011.01.034

Article  PubMed  PubMed Central  Google Scholar 

Blanchard G, Pich C, Hohl D (2022) HaCaT cells as a model system to study primary cilia in keratinocytes. Exp Dermatol 31:1276–1280. https://doi.org/10.1111/exd.14626

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonvini P, Zorzi E, Basso G, Rosolen A (2007) Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia 21:838–842. https://doi.org/10.1038/sj.leu.2404528

Article  CAS  PubMed  Google Scholar 

Brewer JW, Hendershot LM, Sherr CJ, Diehl JA (1999) Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci U S A 96:8505–8510. https://doi.org/10.1073/pnas.96.15.8505

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bullenkamp J, Raulf N, Ayaz B, Walczak H, Kulms D, Odell E, Thavaraj S, Tavassoli M (2014) Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism. Cell Death Dis 5:e1489. https://doi.org/10.1038/cddis.2014.455

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Ricker JL, Malhotra PS, Nottingham L, Bagain L, Lee TL, Yeh NT, Van Waes C (2008) Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-κB and activator protein-1 related mechanisms. Mol Cancer Ther 7:1949–1960. https://doi.org/10.1158/1535-7163.MCT-07-2046

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH (2014) XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 508:103–107. https://doi.org/10.1038/nature13119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y-C, Chen B-C, Huang H-M, Lin S-H, Lin C-H (2019) Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: inhibitory effects of curcumin. J Cell Physiol 234:15977–15988. https://doi.org/10.1002/jcp.28256

Article  CAS  PubMed  Google Scholar 

Chen K, Wang Z, Liu C, Yang X, Jiang J (2022) Sphingosine-1-phosphate attenuates endoplasmic reticulum stress-induced cardiomyocyte apoptosis through sphingosine-1-phosphate receptor 1. Arch Med Res 53:562–573. https://doi.org/10.1016/j.arcmed.2022.08.002

Article  CAS  PubMed  Google Scholar 

Chu H-S, Peterson C, Chamling X, Berlinicke C, Zack D, Jun AS, Foster J (2022) Integrated stress response regulation of corneal epithelial cell motility and cytokine production. Invest Ophthalmol vis Sci 63:1. https://doi.org/10.1167/iovs.63.8.1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cleland WW (1964) Dithiothreitol, a new protective reagent for SH groups. Biochemistry 3:480–482. https://doi.org/10.1021/bi00892a002

Article  CAS  PubMed  Google Scholar 

Cole DW, Svider PF, Shenouda KG, Lee PB, Yoo NG, McLeod TM, Mutchnick SA, Yoo GH, Kaufman RJ, Callaghan MU, Fribley AM (2019) Targeting the unfolded protein response in head and neck and oral cavity cancers. Exp Cell Res 382:111386. https://doi.org/10.1016/j.yexcr.2019.04.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deyrieux AF, Wilson VG (2007) In vitro culture conditions to study keratinocyte differentiation using the HaCaT cell line. Cytotechnology 54:77. https://doi.org/10.1007/s10616-007-9076-1

Article  PubMed  PubMed Central  Google Scholar 

Fang J, de Bruin A, Villunger A, Schiffelers R, Lei Z, Sluijter JPG (2022) Cellular polyploidy in organ homeostasis and regeneration. Protein Cell 14:560–578. https://doi.org/10.1093/procel/pwac064

Article  CAS  Google Scholar 

Freije A, Ceballos L, Coisy M, Barnes L, Rosa M, De Diego E, Blanchard JM, Gandarillas A (2012) Cyclin E drives human keratinocyte growth into differentiation. Oncogene 31:5180–5192. https://doi.org/10.1038/onc.2012.22

Article  CAS  PubMed  Google Scholar 

Gandarillas A, Davies D, Blanchard JM (2000) Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication. Oncogene 19:3278–3289. https://doi.org/10.1038/sj.onc.1203630

Article  CAS  PubMed  Google Scholar 

Gandarillas A, Sanz-Gómez N, Freije A (2019) Polyploidy and the mitosis path to epidermal cell fate. Cell Cycle 18:359–362. https://doi.org/10.1080/15384101.2019.1568766

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gebert M, Sobolewska A, Bartoszewska S, Cabaj A, Crossman DK, Króliczewski J, Madanecki P, Dąbrowski M, Collawn JF, Bartoszewski R (2021) Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor. Cell Mol Life Sci 78:7061–7080. https://doi.org/10.1007/s00018-021-03952-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo Y, Han B, Yang T, Chen Y, Yang Y, Liang C, Li J, Yang Q, Xie R (2022) Dithiothreitol promotes apoptosis in rat hepatocytes by inhibiting family with sequence similarity 134 member B (FAM134B)-mediated endoplasmic reticulophagy. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38:1104–1110

PubMed  Google Scholar 

Han X, Zhang X, Li H, Huang S, Zhang S, Wang F, Shi Y (2015) Tunicamycin enhances the antitumor activity of trastuzumab on breast cancer in vitro and in vivo. Oncotarget 6:38912–38925. https://doi.org/10.18632/oncotarget.5334

Article  PubMed  PubMed Central  Google Scholar 

He D, Sassa S, Lim HW (1993) Effect of UVA and blue light on porphyrin biosynthesis in epidermal cells. Photochem Photobiol 57:825–829. https://doi.org/10.1111/j.1751-1097.1993.tb09218.x

Article  CAS  PubMed 

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