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Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives
Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives
Joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), ...
ER stress affects proliferation and induces polyploidization of cultured human HaCaT and A431 cells
ER stress affects proliferation and induces polyploidization of cultured human HaCaT and A431 cells
Endoplasmic reticulum (ER) stress is the accumulation of misfolded or defective proteins in the ER. ER stress is capable o...
Fiber type-specific expression of LACTB leverages a function in oxidative metabolism
Fiber type-specific expression of LACTB leverages a function in oxidative metabolism
Skeletal muscle is composed of type I and type II fibers, each characterized by specific metabolic machinery. LACTB is a c...
Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming
Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming
During the conversion of fibroblasts into induced pluripotent stem cells (iPSCs), cellular metabolism shifts from oxidativ...
Oncogenic overexpression of kallikrein-related peptidase 7 is associated with the progression of thyroid cancer
Oncogenic overexpression of kallikrein-related peptidase 7 is associated with the progression of thyroid cancer
Mounting evidence suggests that the kallikrein-related peptidase family is dysregulated in thyroid cancer. However, previo...
Localization of dendritic cells and T cells within the tumor microenvironment in different types of skin cancer
Localization of dendritic cells and T cells within the tumor microenvironment in different types of skin cancer
Immunophenotyping of tumor-infiltrating immune cells is increasingly important for understanding the tumor microenvironmen...
SASP-driven vascular aging: unraveling the transcriptional nexus in endothelial senescence and cardiovascular disease
SASP-driven vascular aging: unraveling the transcriptional nexus in endothelial senescence and cardiovascular disease
Endothelial cell senescence represents a critical mechanistic driver in the initiation and progression of cardiovascular d...
Effects of obesity on DNA methylation and DNA methyltransferases in the reproductive system
Effects of obesity on DNA methylation and DNA methyltransferases in the reproductive system
Obesity is increasingly recognized as a condition with profound systemic and epigenetic consequences. However, the molecul...
Approaches to visualize, quantify, and manipulate phosphoinositides in cells
Approaches to visualize, quantify, and manipulate phosphoinositides in cells
Phosphoinositides are low-abundance regulatory lipids that control a broad range of cellular processes, from membrane traf...
Methodological framework for chromogenic mRNA detection using in situ hybridization chain reaction
Methodological framework for chromogenic mRNA detection using in situ hybridization chain reaction
In situ hybridization chain reaction (HCR) is a highly sensitive method for visualizing single-molecule messenger RNA (mRN...
The peroxisomal importomer can accommodate an intrinsically disordered protein of 1247 residues
The peroxisomal importomer can accommodate an intrinsically disordered protein of 1247 residues
Peroxisomal matrix proteins are nuclear encoded and synthesized in the cytosol. It is well established that folded, cofact...
Artificial intelligence in small tissue biopsies: diagnostic applications, histochemical integration, and methodological challenges in surgical pathology
Artificial intelligence in small tissue biopsies: diagnostic applications, histochemical integration, and methodological challenges in surgical pathology
Small tissue biopsies, including renal core biopsies, bone marrow trephines, gastrointestinal endoscopic samples, prostate...
Modulation of angiogenic, inflammatory, and matrix remodeling responses in type 2 diabetic wounds by a decellularized dermal scaffold and adjunct biophysical stimulation
Modulation of angiogenic, inflammatory, and matrix remodeling responses in type 2 diabetic wounds by a decellularized dermal scaffold and adjunct biophysical stimulation
Impaired wound healing in type 2 diabetes is largely attributed to dysregulated cellular responses, defective extracellula...
DHX37 protein and mRNA expression patterns in breast and ovarian cancer and their prognostic implications
DHX37 protein and mRNA expression patterns in breast and ovarian cancer and their prognostic implications
DEAH-box RNA helicase 37 (DHX37) is a highly conserved RNA helicase involved in ribosome biogenesis, RNA metabolism and im...
Visualisation of peroxisomes: a journey through seven decades
Visualisation of peroxisomes: a journey through seven decades
Peroxisomes are ubiquitous, oxidative organelles in eukaryotes with conserved functions in cellular lipid metabolism and r...
A rapid and robust translational model for testicular aging research
A rapid and robust translational model for testicular aging research
In humans, testicular peritubular cells (TPCs) form a small compartment surrounding the seminiferous tubules and, as shown...
AGEs derived from high-sugar diets induce functional impairment of odontogenic stem cells via RAGE-mediated endoplasmic reticulum stress
AGEs derived from high-sugar diets induce functional impairment of odontogenic stem cells via RAGE-mediated endoplasmic reticulum stress
This investigation sought to determine whether the formation and progressive buildup of advanced glycation end products (A...
The stem cell potential of bovine milk: a comparative study of colostrum and mature milk
The stem cell potential of bovine milk: a comparative study of colostrum and mature milk
Mesenchymal stem cells (MSCs) are widely utilized in regenerative medicine owing to their differentiation potential and pa...
Epigenetic orchestration by DNMT3B and DNMT3L throughout oocyte maturation
Epigenetic orchestration by DNMT3B and DNMT3L throughout oocyte maturation
DNA methylation represents a fundamental epigenetic mechanism regulating gene expression and developmental processes. In t...
Exploring the expression of MMP-2, MT1-MMP, and MMP-9 in the pectoral muscle of Ross chickens during E11, E15, and E19 of fetal development
Exploring the expression of MMP-2, MT1-MMP, and MMP-9 in the pectoral muscle of Ross chickens during E11, E15, and E19 of fetal development
There are pertinent studies on the relationship between matrix metalloproteinases (MMPs) and muscle cell differentiation i...
Secreted Frizzled-related proteins in animal development
Secreted Frizzled-related proteins in animal development
Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and ant...
Development of optimized differentiation media for murine bone marrow multipotent mesenchymal stromal cells
Development of optimized differentiation media for murine bone marrow multipotent mesenchymal stromal cells
Here, we aimed to define adipogenic, osteogenic, and chondrogenic media for the differentiation of murine mesenchymal stro...
Comparative assessment of human chondroprogenitor viability and molecular phenotype in various parenteral transport media
Comparative assessment of human chondroprogenitor viability and molecular phenotype in various parenteral transport media
Chondroprogenitors derived from articular cartilage offer a promising approach for treating cartilage pathologies owing to...
Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification
Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification
Ascl1 (Mash1), a bHLH transcription factor, is widely expressed by neuronal progenitors. The gene plays a key role in the ...
Extracellular matrix reorganization during endometrial decidualization
Extracellular matrix reorganization during endometrial decidualization
Extracellular matrix reorganization, a concurrent process of endometrial decidualization, has garnered widespread recognit...
The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury
The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury
Type 1 diabetes mellitus (T1DM) is associated with oxidative stress and inflammation in the liver, which contribute to hep...
Telocytes: history, origin, identification, structure, distribution, and functions
Telocytes: history, origin, identification, structure, distribution, and functions
Telocytes are specialized interstitial cells characterized by their unique structure, which features a relatively small ce...
Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study
Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study
Oxidative stress is known to have a detrimental effect on wound healing following oral mucosal injuries. Exogenous antioxi...
MyoAnalyst: an ImageJ plugin for accurate and automatic myofiber segmentation and analysis in skeletal muscle cross sections
MyoAnalyst: an ImageJ plugin for accurate and automatic myofiber segmentation and analysis in skeletal muscle cross sections
Quantifying myofiber size is essential for assessing the health and function of skeletal muscle. Although several ImageJ p...
July in focus in HCB
July in focus in HCB
The inhibitor of growth protein family (ING) consists of at least five family members (ING1–5), with a range of proposed a...
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