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Molecular basis for the biosynthesis of the siderophore coprogen in the cheese-ripening fungus Penicillium roqueforti
Molecular basis for the biosynthesis of the siderophore coprogen in the cheese-ripening fungus Penicillium roqueforti
Iron is an essential nutrient for microorganisms, including fungi, which have evolved strategies to acquire it. The most c...
Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging
Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging
The paravertebral muscles play a critical role in maintaining dynamic spinal stability and physiological function. With ag...
Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity
Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity
Maintenance of nucleosome-free regions at gene regulatory regions conform a relevant aspect within chromatin dynamics. In ...
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare...
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
NADPH oxidases (NOX) are membrane-bound proteins involved in the localized generation of reactive oxygen species (ROS) at ...
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap ...
Are we cultivating the perfect storm for a human avian influenza pandemic?
Are we cultivating the perfect storm for a human avian influenza pandemic?
The emergence of highly pathogenic avian influenza (HPAI) A H5N1 virus in dairy cattle marks a troubling new chapter in th...
Regional Hereditary Cancer Program in Chile: A scalable model of genetic counseling and molecular diagnosis to improve clinical outcomes for patients with hereditary cancer across Latin America
Regional Hereditary Cancer Program in Chile: A scalable model of genetic counseling and molecular diagnosis to improve clinical outcomes for patients with hereditary cancer across Latin America
Breast cancer is a leading cause of cancer-related mortality worldwide, with hereditary forms accounting for approximately...
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome ...
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial s...
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG...
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo ...
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to med...
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the ...
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies sugg...
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced ...
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been...
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Anther development and pollen fertility of cytoplasmic male sterility (CMS) conditioned by Gossypium harknessii cytoplasm ...
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disord...
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated ...
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
In vitro incubation of epididymal and vas deferens sperm with Mn2+ induces Sperm Chromatin Fragmentation (SCF), a mechanis...
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An as...
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
Angiotensin converting enzyme 2 (ACE2) plays a crucial role in the infection cycle of SARS-CoV-2 responsible for formation...
Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery
Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery
Ischemic stroke is a severe type of stroke with high disability and mortality rates. In recent years, microglial exosome-d...
S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis
S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis
Nitric oxide is produced by different nitric oxide synthases isoforms. NO activates two signaling pathways, one dependent ...
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis
Intracranial aneurysm (IA) is the most common cerebrovascular disease, and subarachnoid hemorrhage caused by its rupture c...
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
The endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic termi...
Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway
Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway
To elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose uptake and apoptosis) of gestational diabetes ...
Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem ...
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture...
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