Al-Hadyan KS, Storr SJ, Zaitoun AM, Lobo DN, Martin SG (2024) Thioredoxin system protein expression in carcinomas of the pancreas, distal bile duct, and ampulla in the United Kingdom. Diseases. https://doi.org/10.3390/diseases12100227
Article PubMed PubMed Central Google Scholar
Boneberg FM, Brandmann T, Kobel L, van den Heuvel J, Bargsten K, Bammert L, Kutay U, Jinek M (2019) Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. RNA 25(6):685–701. https://doi.org/10.1261/rna.069609.118
Article CAS PubMed PubMed Central Google Scholar
Buonocore F, Clifford-Mobley O, King TFJ, Striglioni N, Man E, Suntharalingham JP, Del Valle I, Lin L, Lagos CF, Rumsby G, Conway GS, Achermann JC (2019) Next-generation sequencing reveals novel genetic variants (SRY, DMRT1, NR5A1, DHH, DHX37) in adults with 46,XY DSD. J Endocr Soc 3(12):2341–2360. https://doi.org/10.1210/js.2019-00306
Article CAS PubMed PubMed Central Google Scholar
Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10(21):7252–7259. https://doi.org/10.1158/1078-0432.CCR-04-0713
Article CAS PubMed Google Scholar
Cancer Genome Atlas Research N, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich D, Sander C, Stuart JM (2013) The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45(10):1113–1120. https://doi.org/10.1038/ng.2764
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401–404. https://doi.org/10.1158/2159-8290.CD-12-0095
Article PubMed PubMed Central Google Scholar
Choudhury P, Hackert P, Memet I, Sloan KE, Bohnsack MT (2019) The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles. RNA Biol 16(1):54–68. https://doi.org/10.1080/15476286.2018.1556149
da Silva TE, Gomes NL, Lerario AM, Keegan CE, Nishi MY, Carvalho FM, Vilain E, Barseghyan H, Martinez-Aguayo A, Forclaz MV, Papazian R, Pedroso de Paula LC, Costa EC, Carvalho LR, Jorge AAL, Elias FM, Mitchell R, Costa EMF, Mendonca BB, Domenice S (2019) Genetic evidence of the association of DEAH-box helicase 37 defects with 46,XY gonadal dysgenesis spectrum. J Clin Endocrinol Metab 104(12):5923–5934. https://doi.org/10.1210/jc.2019-00984
Devasahayam Arokia Balaya R, Kanekar S, Kumar S, Kandasamy RK (2025) Role of DEAD/DEAH-box helicases in immunity, infection and cancers. Cell Commun Signal 23(1):292. https://doi.org/10.1186/s12964-025-02225-9
Article CAS PubMed PubMed Central Google Scholar
Dong MB, Wang G, Chow RD, Ye L, Zhu L, Dai X, Park JJ, Kim HR, Errami Y, Guzman CD, Zhou X, Chen KY, Renauer PA, Du Y, Shen J, Lam SZ, Zhou JJ, Lannin DR, Herbst RS, Chen S (2019) Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells. Cell 178(5):1189-1204 e1123. https://doi.org/10.1016/j.cell.2019.07.044
Article CAS PubMed PubMed Central Google Scholar
Fiorenzani C, Mossa A, De Rubeis S (2025) DEAD/DEAH-box RNA helicases shape the risk of neurodevelopmental disorders. Trends Genet 41(5):437–449. https://doi.org/10.1016/j.tig.2024.12.006
Article CAS PubMed PubMed Central Google Scholar
Fuller-Pace FV (2013) DEAD box RNA helicase functions in cancer. RNA Biol 10(1):121–132. https://doi.org/10.4161/rna.23312
Article CAS PubMed PubMed Central Google Scholar
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6(269):pl1. https://doi.org/10.1126/scisignal.2004088
Article CAS PubMed PubMed Central Google Scholar
Heath AP, Ferretti V, Agrawal S, An M, Angelakos JC, Arya R, Bajari R, Baqar B, Barnowski JHB, Burt J, Catton A, Chan BF, Chu F, Cullion K, Davidsen T, Do PM, Dompierre C, Ferguson ML, Fitzsimons MS, Ford M, Fukuma M, Gaheen S, Ganji GL, Garcia TI, George SS, Gerhard DS, Gerthoffert F, Gomez F, Han K, Hernandez KM, Issac B, Jackson R, Jensen MA, Joshi S, Kadam A, Khurana A, Kim KMJ, Kraft VE, Li S, Lichtenberg TM, Lodato J, Lolla L, Martinov P, Mazzone JA, Miller DP, Miller I, Miller JS, Miyauchi K, Murphy MW, Nullet T, Ogwara RO, Ortuno FM, Pedrosa J, Pham PL, Popov MY, Porter JJ, Powell R, Rademacher K, Reid CP, Rich S, Rogel B, Sahni H, Savage JH, Schmitt KA, Simmons TJ, Sislow J, Spring J, Stein L, Sullivan S, Tang Y, Thiagarajan M, Troyer HD, Wang C, Wang Z, West BL, Wilmer A, Wilson S, Wu K, Wysocki WP, Xiang L, Yamada JT, Yang L, Yu C, Yung CK, Zenklusen JC, Zhang J, Zhang Z, Zhao Y, Zubair A, Staudt LM, Grossman RL (2021) The NCI genomic data commons. Nat Genet 53(3):257–262. https://doi.org/10.1038/s41588-021-00791-5
Article CAS PubMed Google Scholar
Huang K, Pang T, Tong C, Chen H, Nie Y, Wu J, Zhang Y, Chen G, Zhou W, Yang D (2021) Integrative expression and prognosis analysis of DHX37 in human cancers by data mining. BioMed Res Int 2021:6576210. https://doi.org/10.1155/2021/6576210
Article CAS PubMed PubMed Central Google Scholar
Jankowsky E (2011) RNA helicases at work: binding and rearranging. Trends Biochem Sci 36(1):19–29. https://doi.org/10.1016/j.tibs.2010.07.008
Article CAS PubMed PubMed Central Google Scholar
Kobel M, Kang EY, Weir A, Rambau PF, Lee CH, Nelson GS, Ghatage P, Meagher NS, Riggan MJ, Alsop J, Anglesio MS, Beckmann MW, Bisinotto C, Boisen M, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, Deen S, El-Bahrawy MA, Elishaev E, Erber R, Fereday S, Group A, Fischer A, Gayther SA, Barquin-Garcia A, Gentry-Maharaj A, Gilks CB, Gronwald H, Grube M, Harnett PR, Harris HR, Hartkopf AD, Hartmann A, Hein A, Hendley J, Hernandez BY, Huang Y, Jakubowska J, Jimenez-Linan M, Jones ME, Kennedy CJ, Kluz T, Koziak JM, Lesnock J, Lester J, Lubinski J, Longacre TA, Lycke M, Mateoiu C, McCauley BM, McGuire V, Ney B, Olawaiye A, Orsulic S, Osorio A, Paz-Ares L, Ramon YCT, Rothstein JH, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Steed H, Storr SJ, Talhouk A, Traficante N, Wang C, Whittemore AS, Widschwendter M, Wilkens LR, Winham SJ, Benitez J, Berchuck A, Bowtell DD, Candido Dos Reis FJ, Campbell I, Cook LS, DeFazio A, Doherty JA, Fasching PA, Fortner RT, Garcia MJ, Goodman MT, Goode EL, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Kommoss S, Le ND, Martin SG, Menon U, Modugno F, Pharoah PD, Schildkraut JM, Sieh W, Staebler A, Sundfeldt K, Swerdlow AJ, Ramus SJ, Brenton JD (2023) p53 and ovarian carcinoma survival: an ovarian tumor tissue analysis consortium study. J Pathol Clin Res 9(3):208–222. https://doi.org/10.1002/cjp2.311
Article CAS PubMed PubMed Central Google Scholar
Lacey K, Greener MR, Marak TR, Rakha EA, Green AR, Ellis IO, Martin SG, Storr SJ (2024) Protein tyrosine kinase 7 (PTK7) in breast cancer: a retrospective analysis of tumour expression and association with clinical outcome. Cancers (Basel). https://doi.org/10.3390/cancers16183206
Article PubMed PubMed Central Google Scholar
Liu R, Iadevaia V, Averous J, Taylor PM, Zhang Z, Proud CG (2014) Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors. Nucleic Acids Res 42(8):5083–5096. https://doi.org/10.1093/nar/gku130
Article CAS PubMed PubMed Central Google Scholar
Liu Z, Ye Y, Liu Y, Liu Y, Chen H, Shen M, Wang Z, Huang S, Han L, Chen Z, He X (2022) RNA helicase DHX37 facilitates liver cancer progression by cooperating with PLRG1 to drive superenhancer-mediated transcription of Cyclin D1. Cancer Res 82(10):1937–1952. https://doi.org/10.1158/0008-5472.CAN-21-3038
Article CAS PubMed PubMed Central Google Scholar
McElreavey K, Jorgensen A, Eozenou C, Merel T, Bignon-Topalovic J, Tan DS, Houzelstein D, Buonocore F, Warr N, Kay RGG, Peycelon M, Siffroi JP, Mazen I, Achermann JC, Shcherbak Y, Leger J, Sallai A, Carel JC, Martinerie L, Le Ru R, Conway GS, Mignot B, Van Maldergem L, Bertalan R, Globa E, Brauner R, Jauch R, Nef S, Greenfield A, Bashamboo A (2020) Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY Gonadal Dysgenesis and 46,XY Testicular Regression Syndrome. Genet Med 22(1):150–159. https://doi.org/10.1038/s41436-019-0606-y
Article CAS PubMed Google Scholar
Murayama T, Nakayama J, Jiang X, Miyata K, Morris AD, Cai KQ, Prasad RM, Ma X, Efimov A, Belani N, Gerstein ER, Tan Y, Zhou Y, Kim W, Maruyama R, Campbell KS, Chen L, Yang Y, Balachandran S, Canadas I (2024) Targeting DHX9 triggers tumor-intrinsic Interferon response and replication stress in small cell lung cancer. Cancer Discov 14(3):468–491. https://doi.org/10.1158/2159-8290.CD-23-0486
Comments (0)