DHX37 protein and mRNA expression patterns in breast and ovarian cancer and their prognostic implications

Al-Hadyan KS, Storr SJ, Zaitoun AM, Lobo DN, Martin SG (2024) Thioredoxin system protein expression in carcinomas of the pancreas, distal bile duct, and ampulla in the United Kingdom. Diseases. https://doi.org/10.3390/diseases12100227

Article  PubMed  PubMed Central  Google Scholar 

Boneberg FM, Brandmann T, Kobel L, van den Heuvel J, Bargsten K, Bammert L, Kutay U, Jinek M (2019) Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. RNA 25(6):685–701. https://doi.org/10.1261/rna.069609.118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buonocore F, Clifford-Mobley O, King TFJ, Striglioni N, Man E, Suntharalingham JP, Del Valle I, Lin L, Lagos CF, Rumsby G, Conway GS, Achermann JC (2019) Next-generation sequencing reveals novel genetic variants (SRY, DMRT1, NR5A1, DHH, DHX37) in adults with 46,XY DSD. J Endocr Soc 3(12):2341–2360. https://doi.org/10.1210/js.2019-00306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10(21):7252–7259. https://doi.org/10.1158/1078-0432.CCR-04-0713

Article  CAS  PubMed  Google Scholar 

Cancer Genome Atlas Research N, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich D, Sander C, Stuart JM (2013) The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45(10):1113–1120. https://doi.org/10.1038/ng.2764

Article  CAS  Google Scholar 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401–404. https://doi.org/10.1158/2159-8290.CD-12-0095

Article  PubMed  PubMed Central  Google Scholar 

Choudhury P, Hackert P, Memet I, Sloan KE, Bohnsack MT (2019) The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles. RNA Biol 16(1):54–68. https://doi.org/10.1080/15476286.2018.1556149

Article  PubMed  Google Scholar 

da Silva TE, Gomes NL, Lerario AM, Keegan CE, Nishi MY, Carvalho FM, Vilain E, Barseghyan H, Martinez-Aguayo A, Forclaz MV, Papazian R, Pedroso de Paula LC, Costa EC, Carvalho LR, Jorge AAL, Elias FM, Mitchell R, Costa EMF, Mendonca BB, Domenice S (2019) Genetic evidence of the association of DEAH-box helicase 37 defects with 46,XY gonadal dysgenesis spectrum. J Clin Endocrinol Metab 104(12):5923–5934. https://doi.org/10.1210/jc.2019-00984

Article  PubMed  Google Scholar 

Devasahayam Arokia Balaya R, Kanekar S, Kumar S, Kandasamy RK (2025) Role of DEAD/DEAH-box helicases in immunity, infection and cancers. Cell Commun Signal 23(1):292. https://doi.org/10.1186/s12964-025-02225-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong MB, Wang G, Chow RD, Ye L, Zhu L, Dai X, Park JJ, Kim HR, Errami Y, Guzman CD, Zhou X, Chen KY, Renauer PA, Du Y, Shen J, Lam SZ, Zhou JJ, Lannin DR, Herbst RS, Chen S (2019) Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells. Cell 178(5):1189-1204 e1123. https://doi.org/10.1016/j.cell.2019.07.044

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fiorenzani C, Mossa A, De Rubeis S (2025) DEAD/DEAH-box RNA helicases shape the risk of neurodevelopmental disorders. Trends Genet 41(5):437–449. https://doi.org/10.1016/j.tig.2024.12.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fuller-Pace FV (2013) DEAD box RNA helicase functions in cancer. RNA Biol 10(1):121–132. https://doi.org/10.4161/rna.23312

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6(269):pl1. https://doi.org/10.1126/scisignal.2004088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heath AP, Ferretti V, Agrawal S, An M, Angelakos JC, Arya R, Bajari R, Baqar B, Barnowski JHB, Burt J, Catton A, Chan BF, Chu F, Cullion K, Davidsen T, Do PM, Dompierre C, Ferguson ML, Fitzsimons MS, Ford M, Fukuma M, Gaheen S, Ganji GL, Garcia TI, George SS, Gerhard DS, Gerthoffert F, Gomez F, Han K, Hernandez KM, Issac B, Jackson R, Jensen MA, Joshi S, Kadam A, Khurana A, Kim KMJ, Kraft VE, Li S, Lichtenberg TM, Lodato J, Lolla L, Martinov P, Mazzone JA, Miller DP, Miller I, Miller JS, Miyauchi K, Murphy MW, Nullet T, Ogwara RO, Ortuno FM, Pedrosa J, Pham PL, Popov MY, Porter JJ, Powell R, Rademacher K, Reid CP, Rich S, Rogel B, Sahni H, Savage JH, Schmitt KA, Simmons TJ, Sislow J, Spring J, Stein L, Sullivan S, Tang Y, Thiagarajan M, Troyer HD, Wang C, Wang Z, West BL, Wilmer A, Wilson S, Wu K, Wysocki WP, Xiang L, Yamada JT, Yang L, Yu C, Yung CK, Zenklusen JC, Zhang J, Zhang Z, Zhao Y, Zubair A, Staudt LM, Grossman RL (2021) The NCI genomic data commons. Nat Genet 53(3):257–262. https://doi.org/10.1038/s41588-021-00791-5

Article  CAS  PubMed  Google Scholar 

Huang K, Pang T, Tong C, Chen H, Nie Y, Wu J, Zhang Y, Chen G, Zhou W, Yang D (2021) Integrative expression and prognosis analysis of DHX37 in human cancers by data mining. BioMed Res Int 2021:6576210. https://doi.org/10.1155/2021/6576210

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jankowsky E (2011) RNA helicases at work: binding and rearranging. Trends Biochem Sci 36(1):19–29. https://doi.org/10.1016/j.tibs.2010.07.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kobel M, Kang EY, Weir A, Rambau PF, Lee CH, Nelson GS, Ghatage P, Meagher NS, Riggan MJ, Alsop J, Anglesio MS, Beckmann MW, Bisinotto C, Boisen M, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, Deen S, El-Bahrawy MA, Elishaev E, Erber R, Fereday S, Group A, Fischer A, Gayther SA, Barquin-Garcia A, Gentry-Maharaj A, Gilks CB, Gronwald H, Grube M, Harnett PR, Harris HR, Hartkopf AD, Hartmann A, Hein A, Hendley J, Hernandez BY, Huang Y, Jakubowska J, Jimenez-Linan M, Jones ME, Kennedy CJ, Kluz T, Koziak JM, Lesnock J, Lester J, Lubinski J, Longacre TA, Lycke M, Mateoiu C, McCauley BM, McGuire V, Ney B, Olawaiye A, Orsulic S, Osorio A, Paz-Ares L, Ramon YCT, Rothstein JH, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Steed H, Storr SJ, Talhouk A, Traficante N, Wang C, Whittemore AS, Widschwendter M, Wilkens LR, Winham SJ, Benitez J, Berchuck A, Bowtell DD, Candido Dos Reis FJ, Campbell I, Cook LS, DeFazio A, Doherty JA, Fasching PA, Fortner RT, Garcia MJ, Goodman MT, Goode EL, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Kommoss S, Le ND, Martin SG, Menon U, Modugno F, Pharoah PD, Schildkraut JM, Sieh W, Staebler A, Sundfeldt K, Swerdlow AJ, Ramus SJ, Brenton JD (2023) p53 and ovarian carcinoma survival: an ovarian tumor tissue analysis consortium study. J Pathol Clin Res 9(3):208–222. https://doi.org/10.1002/cjp2.311

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lacey K, Greener MR, Marak TR, Rakha EA, Green AR, Ellis IO, Martin SG, Storr SJ (2024) Protein tyrosine kinase 7 (PTK7) in breast cancer: a retrospective analysis of tumour expression and association with clinical outcome. Cancers (Basel). https://doi.org/10.3390/cancers16183206

Article  PubMed  PubMed Central  Google Scholar 

Liu R, Iadevaia V, Averous J, Taylor PM, Zhang Z, Proud CG (2014) Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors. Nucleic Acids Res 42(8):5083–5096. https://doi.org/10.1093/nar/gku130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Ye Y, Liu Y, Liu Y, Chen H, Shen M, Wang Z, Huang S, Han L, Chen Z, He X (2022) RNA helicase DHX37 facilitates liver cancer progression by cooperating with PLRG1 to drive superenhancer-mediated transcription of Cyclin D1. Cancer Res 82(10):1937–1952. https://doi.org/10.1158/0008-5472.CAN-21-3038

Article  CAS  PubMed  PubMed Central  Google Scholar 

McElreavey K, Jorgensen A, Eozenou C, Merel T, Bignon-Topalovic J, Tan DS, Houzelstein D, Buonocore F, Warr N, Kay RGG, Peycelon M, Siffroi JP, Mazen I, Achermann JC, Shcherbak Y, Leger J, Sallai A, Carel JC, Martinerie L, Le Ru R, Conway GS, Mignot B, Van Maldergem L, Bertalan R, Globa E, Brauner R, Jauch R, Nef S, Greenfield A, Bashamboo A (2020) Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY Gonadal Dysgenesis and 46,XY Testicular Regression Syndrome. Genet Med 22(1):150–159. https://doi.org/10.1038/s41436-019-0606-y

Article  CAS  PubMed  Google Scholar 

Murayama T, Nakayama J, Jiang X, Miyata K, Morris AD, Cai KQ, Prasad RM, Ma X, Efimov A, Belani N, Gerstein ER, Tan Y, Zhou Y, Kim W, Maruyama R, Campbell KS, Chen L, Yang Y, Balachandran S, Canadas I (2024) Targeting DHX9 triggers tumor-intrinsic Interferon response and replication stress in small cell lung cancer. Cancer Discov 14(3):468–491. https://doi.org/10.1158/2159-8290.CD-23-0486

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif