World Health Organization. Maternal mortality. WHO https://www.who.int/news-room/fact-sheets/detail/maternal-mortality (2025).
Bell, M. J. A historical overview of preeclampsia-eclampsia. J. Obstet. Gynecol. Neonatal Nurs. 39, 510–518 (2010).
Article PubMed PubMed Central Google Scholar
Fishel Bartal, M., Lindheimer, M. D. & Sibai, B. M. Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance. Am. J. Obstet. Gynecol. 226, S819–S834 (2022).
Article CAS PubMed Google Scholar
Staff, A. C. et al. Failure of physiological transformation and spiral artery atherosis: their roles in pre-eclampsia. Am. J. Obstet. Gynecol. 226, S895–S906 (2022).
Article CAS PubMed Google Scholar
Burton, G. J. & Jauniaux, E. Pathophysiology of placental-derived fetal growth restriction. Am. J. Obstet. Gynecol. 218, S745–S761 (2018).
Article CAS PubMed Google Scholar
Magee, L. A. et al. The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens. 27, 148–169 (2022).
Altman, D. et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie trial: a randomised placebo-controlled trial. Lancet 359, 1877–1890 (2002).
von Schmidt auf Altenstadt, J. F., Hukkelhoven, C. W., van Roosmalen, J. & Bloemenkamp, K. W. Pre-eclampsia increases the risk of postpartum haemorrhage: a nationwide cohort study in the Netherlands. PLoS ONE 8, e81959 (2013).
Article PubMed PubMed Central Google Scholar
Khan, S. et al. Pre-eclampsia and eclampsia-specific maternal mortality in Bangladesh: levels, trends, timing, and care-seeking practices. J. Glob. Health. 14, 07003 (2023).
Churchill, D. et al. Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks’ gestation. Cochrane Database Syst. Rev. 10, CD003106 (2018).
PubMed PubMed Central Google Scholar
Awaludin, A., Rahayu, C., Daud, N. A. A. & Zakiyah, N. Antihypertensive medications for severe hypertension in pregnancy: a systematic review and meta-analysis. Healthcare 10, 325 (2022).
Article PubMed PubMed Central Google Scholar
Erez, O. et al. DIC in pregnancy — pathophysiology, clinical characteristics, diagnostic scores, and treatments. J. Blood Med. 13, 21–44 (2022).
Article CAS PubMed PubMed Central Google Scholar
Tita, A. T. et al. Adjunctive azithromycin prophylaxis for cesarean delivery. N. Engl. J. Med. 375, 1231–1241 (2016).
Article PubMed PubMed Central Google Scholar
Havers-Borgersen, E. et al. Pre-eclampsia and long-term risk of venous thromboembolism. JAMA Netw. Open 6, e2343804 (2023).
Article PubMed PubMed Central Google Scholar
Rolnik, D. L. et al. Aspirin versus placebo in pregnancies at high risk for preterm pre-eclampsia. N. Engl. J. Med. 377, 613–622 (2017).
Article CAS PubMed Google Scholar
Askie, L. M., Duley, L., Henderson-Smart, D. J. & Stewart, L. A. & PARIS Collaborative Group. Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data. Lancet 369, 1791–1798 (2007).
Article CAS PubMed Google Scholar
World Bank Group. Maternal mortality ratio (modeled estimate, per 100,000 live births). https://data.worldbank.org/indicator/SH.STA.MMRT?most_recent_value_desc=false (2023).
World Heath Organization Global Health Observatory. SDG Target 3.2: end preventable deaths of newborns and children under 5 years of age. https://www.who.int/data/gho/data/themes/topics/sdg-target-3_2-newborn-and-child-mortality (2023).
World Health Organization Regional Office for Africa, Integrated African Health Observatory. Maternal mortality: the urgency of a systemic and multisectoral approach in mitigating maternal deaths in Africa. https://files.aho.afro.who.int/afahobckpcontainer/production/files/iAHO_Maternal_Mortality_Regional_Factsheet.pdf (2023).
Gordon, A., Raynes-Greenow, C., McGeechan, K., Morris, J. & Jeffery, H. Risk factors for antepartum stillbirth and the influence of maternal age in New South Wales Australia: a population based study. BMC Pregnancy Childbirth 13, 12 (2013).
Article PubMed PubMed Central Google Scholar
Tikkanen, M. Placental abruption: epidemiology, risk factors and consequences. Acta. Obstet. Gynecol. Scand. 90, 140–149 (2011).
Seely, E. W. & Ecker, J. Chronic hypertension in pregnancy. Circulation 129, 1254–61 (2014).
Myers, M. C. et al. Effect of positioning on blood pressure measurement in pregnancy. Pregnancy Hypertens. 27, 110–114 (2022).
Article PubMed PubMed Central Google Scholar
Salazar, M. R. et al. Nocturnal hypertension in high-risk mid-pregnancies predict the development of pre-eclampsia/eclampsia. J. Hypertens. 37, 182–186 (2019).
Article CAS PubMed Google Scholar
Mancia, G., Bombelli, M., Seravalle, G. & Grassi, G. Diagnosis and management of patients with white-coat and masked hypertension. Nat. Rev. Cardiol. 8, 686–693 (2011).
Article CAS PubMed Google Scholar
Roberts, J. M. & Countouris, M. White coat hypertension in pregnancy: the challenge of combining inconsistent data. Hypertension 76, 35–37 (2020).
Article CAS PubMed PubMed Central Google Scholar
Jones, D. W. et al. AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM guideline for the prevention, detection, evaluation and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Hypertension 82, e212–e316 (2025).
Article CAS PubMed Google Scholar
Shanmugalingam, R. et al. A summary of the 2023 Society of Obstetric Medicine of Australia and New Zealand (SOMANZ) hypertension in pregnancy guideline. Med. J. Aust. 220, 582–591 (2024).
Leonard, S. et al. Chronic hypertension during pregnancy: prevalence and treatment in the United States, 2008–2021. Hypertension 8, 1716–1723 (2024).
Malha, L. & August, P. Secondary hypertension in pregnancy. Curr. Hypertens. Rep. 17, 53 (2015).
Mancia, G. et al. Long-term risk of sustained hypertension in white-coat or masked hypertension. Hypertension 54, 226–232 (2009).
Article CAS PubMed Google Scholar
Hadizadeh, S. et al. Development of preeclampsia in pregnant women with white-coat hypertension: a systematic review and meta-analysis. Arch. Gynecol. Obstet. 309, 929–937 (2024).
Salazar, M. R. et al. Masked hypertension and neonatal outcome in high-risk pregnancies. J. Hum. Hypertens. 37, 36–41 (2023).
Article CAS PubMed Google Scholar
Brown, M. A. et al. Ambulatory blood pressure monitoring in pregnancy: what is normal? Am. J. Obstet. Gynecol. 178, 836–842 (1998).
Espeche, W. G. & Salazar, M. R. Ambulatory blood pressure monitoring for diagnosis and management of hypertension in pregnant women. Diagnostics 13, 1457 (2023).
Article CAS PubMed PubMed Central Google Scholar
Pears, S., Makris, A. & Hennessy, A. The chronobiology of blood pressure in pregnancy. Pregnancy Hypertens. 12, 104–109 (2018).
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