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Author Correction: The genetics of hypertension
In the version of this article initially published, there was an error in the third paragraph of the “Hereditary phaeochro...
Selective autophagy in kidney health and disease
Selective autophagy in kidney health and disease
The kidney is a highly metabolically active organ that relies on tightly regulated organelle turnover to maintain cellular...
Anti-neutrophil cytoplasmic antibody-associated vasculitis: biological insights and biomarker-guided disease management
Anti-neutrophil cytoplasmic antibody-associated vasculitis: biological insights and biomarker-guided disease management
Earlier recognition of anti-neutrophil cytoplasmic antibody-associated vasculitis has led to more timely treatment initiat...
Gene–disease relationships for glomerular phenotypes: expert recommendations from ClinGen
Gene–disease relationships for glomerular phenotypes: expert recommendations from ClinGen
Glomerular diseases are complex conditions, many of which have a genetic basis. However, although some genetic variants ca...
The pathophysiology of pre-eclampsia
The pathophysiology of pre-eclampsia
Pre-eclampsia is a serious complication of pregnancy that contributes to maternal and neonatal morbidity and mortality. Ma...
A spatial atlas identifies tertiary lymphoid tissue-like structures in DKD
A new study by Bernhard Dumoulin, Katalin Susztak and colleagues provides insights into the spatial organization of cells ...
HNF1B as a central gatekeeper of tubular homeostasis
HNF1B is a transcription factor important for kidney development, with loss-of-function variants causing a rare, monogenic...
Infrastructure and policy reforms to facilitate collaboration in medical research
Medical research increasingly depends on data-driven, large-scale, multicentric cooperation; however, such cooperation rem...
The kidney harbours a microbiota that may influence lithogenesis
The kidney harbours a microbiota that may influence lithogenesis
A new study provides evidence of an antibiotic-responsive kidney microbiota that may influence the formation of kidney sto...
Artificial intelligence approaches to enable early detection of CKD
The late diagnosis of chronic kidney disease (CKD) is a global problem that limits the opportunity to initiate disease-mod...
Publisher Correction: Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
Department of Paediatric Kidney, Liver, Metabolic and Neurological Diseases, Hannover Medical, School, Hannover, GermanyDi...
Advances and challenges in kidney fibrosis therapeutics
Advances and challenges in kidney fibrosis therapeutics
Chronic kidney disease (CKD) is a major global health burden that affects more than 10% of the adult population. Current t...
Endoplasmic reticulum stress as a driver and therapeutic target for kidney disease
Endoplasmic reticulum stress as a driver and therapeutic target for kidney disease
The endoplasmic reticulum (ER) has crucial roles in metabolically active cells, including protein translation, protein fol...
A personalized vaccine for kidney cancer
Despite the emergence of immune-based therapies, patients who undergo nephrectomy for clear cell renal cell carcinoma (ccR...
Fiji’s rising tide: the growing burden of diabetic kidney disease on emerging nephrology services
A growing burden of diabetic kidney disease in Fiji threatens to overwhelm newly established nephrology services. Greater ...
Progress towards improving blood pressure control
Progress towards improving blood pressure control
Despite the availability of effective therapies, the majority of patients with hypertension have poor blood pressure contr...
Consideration of sex differences is necessary to achieve health equity
Improved understanding of the impact of sex and gender-related factors on human health and disease and the inclusion of pe...
Targeted identification of risk and treatment of diabetic kidney disease
Basic discovery and clinical trials in diabetic kidney disease (DKD) have continued to be reported in 2023 despite the dis...
Differences in the epidemiology, management and outcomes of kidney disease in men and women
Differences in the epidemiology, management and outcomes of kidney disease in men and women
Improved understanding of differences in kidney disease epidemiology, management and outcomes in men and women could help ...
Mechanisms and consequences of sex differences in immune responses
Mechanisms and consequences of sex differences in immune responses
Biological sex differences refer to differences between males and females caused by the sex chromosome complement (that is...
Author Correction: The immunoregulatory roles of non-haematopoietic cells in the kidney
Authors and AffiliationsDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USAGeorge C. Tsokos, Afr...
Renoprotective effects of sparsentan: clinical trial evidence in IgA nephropathy and FSGS
Renoprotective effects of sparsentan: clinical trial evidence in IgA nephropathy and FSGS
In early 2023, the dual endothelin–angiotensin receptor antagonist sparsentan became the first non-immunosuppressive thera...
Targeting APRIL to slow progression of IgA nephropathy
Targeting APRIL to slow progression of IgA nephropathy
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The immunoregulatory roles of non-haematopoietic cells in the kidney
The immunoregulatory roles of non-haematopoietic cells in the kidney
The deposition of immune complexes, activation of complement and infiltration of the kidney by cells of the adaptive and i...
Kidney xenotransplantation edges closer to the clinic
Kidney xenotransplantation edges closer to the clinic
The demand for kidney transplants is far from met by human donors — a problem that may be solved by the clinical tra...
Equitable access to kidney transplants for Aboriginal and Torres Strait Islander people in Australia
Equitable access to kidney transplants for Aboriginal and Torres Strait Islander people in Australia
First Nations peoples in Australia face systemic inequities in access to kidney transplantation. The National Indigenous&a...
Transport and barrier mechanisms that regulate ciliary compartmentalization and ciliopathies
Transport and barrier mechanisms that regulate ciliary compartmentalization and ciliopathies
Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs and signalling molecules tha...
Taking kidney temperatures to detect rejection
Taking kidney temperatures to detect rejection
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A new pathway links iron sensing with histone demethylation and regulation of mTORC1 activity
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Clonal haematopoiesis, ageing and kidney disease
Clonal haematopoiesis, ageing and kidney disease
Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a sizeable proportion of an ind...