Tamanna N, Mahmood N. Food processing and Maillard reaction products: Effect on human health and nutrition. Int J Food Sci Technol. 2015;2015(1):526762.

Google Scholar 

Starowicz M, Zieliński H. How Maillard reaction influences sensorial properties (color, flavor and texture) of dood products? Food Rev Int. 2019;35(8):707–25.

Article  CAS  Google Scholar 

Gerrard JA. The Maillard reaction in food: Progress made, challenges ahead—Conference report from the eighth international symposium on the maillard reaction. Trends in Food Science & Technology. 2006;17(6):324-30.

Zhang F, Yu X, Tian Y, Zeng J, Zhuang P, Jia W, Zhang Y. Joint control of multiple food processing contaminants in Maillard reaction: A comprehensive review of health risks and prevention. Compr Rev Food Sci Food Saf. 2025;24(2):e70138.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Chen Y, Deng P, He Z, Qin F, Chen Q, Wang Z, Pan H, Chen J, Zeng M. Research progress on generation, detection and inhibition of multiple hazards - acrylamide, 5-hydroxymethylfurfural, advanced glycation end products, methylimidazole - in baked goods. Food Chem. 2024;431:137152.

Article  CAS  PubMed  Google Scholar 

Auñon-Lopez A, Strauss M, Hinterreiter-Kern E, Klein A, Varga E, Pignitter M. Influence of processing of seitan, tempeh, and firm regular tofu on protein and lipid oxidation and Maillard reaction products formation. Food Chem. 2025;467:142273.

Article  PubMed  Google Scholar 

Wang C, Yang Y, Wu N, Gao M, Tan Y. Combined toxicity of pyrethroid insecticides and heavy metals: A review. Environ Chem Lett. 2019;17(4):1693–706.

Article  CAS  Google Scholar 

Fu Y, Yin S, Zhao C, Fan L, Hu H. Combined toxicity of food-borne mycotoxins and heavy metals or pesticides. Toxicon. 2022;217:148–54.

Article  CAS  PubMed  Google Scholar 

Hogervorst JG, Baars BJ, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. The carcinogenicity of dietary acrylamide intake: A comparative discussion of epidemiological and experimental animal research. Crit Rev Toxicol. 2010;40(6):485–512.

Article  CAS  PubMed  Google Scholar 

Ahmed MM, Hammad AA, Orabi SH, Elbaz HT, Elweza AE, Tahoun EA, Elseehy MM, El-Shehawi AM, Mousa AA. Reproductive injury in male rats from acrylamide toxicity and potential protection by earthworm methanolic extract. Animals. 2022;12(13):1723.

Article  PubMed  PubMed Central  Google Scholar 

Sun JX, Li MW, Zou FY, Bai S, Jiang XW, Tian LM, Ou SY, Jiao R, Bai WB. Protection of cyanidin-3-glucoside against acrylamide- and glycidamide-induced reproductive toxicity in leydig cells. Food Chem Toxicol. 2018;119:268–74.

Article  CAS  PubMed  Google Scholar 

Liu X, Zheng L, Zhang R, Liu G, Xiao S, Qiao X, Wu Y, Gong Z. Toxicological evaluation of advanced glycation end product Nepsilon-(carboxymethyl)lysine: Acute and subacute oral toxicity studies. Regul Toxicol Pharmacol. 2016;77:65–74.

Article  CAS  PubMed  Google Scholar 

Sun W, Yan S, Meng Z, Tian S, Jia M, Huang S, Wang Y, Zhou Z, Diao J, Zhu W. Combined ingestion of polystyrene microplastics and epoxiconazole increases health risk to mice: Based on their synergistic bioaccumulation in vivo. Environ Int. 2022;166:107391.

Article  CAS  PubMed  Google Scholar 

Wei Q, Li J, Li X, Zhang L, Shi F. Reproductive toxicity in acrylamide-treated female mice. Reprod Toxicol. 2014;46:121–8.

Article  CAS  PubMed  Google Scholar 

Zink D, Chuah JKC, Ying JY. Assessing toxicity with human cell-based in vitro methods. Trends Mol Med. 2020;26(6):570–82.

Article  CAS  PubMed  Google Scholar 

Wu J, Lin X, Li J, Lv Z, Duan N, Wang Z, Wu S. Dual-color nanospheres based on aggregation-induced emission and catalytic hairpin assembly for simultaneous imaging of acrylamide and miR-21 in living cells. J Hazard Mater. 2024;462:132815.

Article  CAS  PubMed  Google Scholar 

Wittek F, Torabi S, Kolb M, Walther UI. Pro-oxidative toxicity of cells in suspension does not point to a cell cultural artefact as an explanation of the increased susceptibility of alveolar epithelial-like cells after glucocorticoid pretreatment. Toxicol Vitro. 2014;28(6):1089–96.

Article  CAS  Google Scholar 

Hipkiss AR, Preston JE, Himswoth DTM, Worthington VC, Abbot NJ. Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells. Neurosci Lett. 1997;238(3):135–8.

Article  CAS  PubMed  Google Scholar 

Jiao GZ, He X, Li X, Qiu JQ, Xu HY, Zhang N, Liu SM. Limitations of MTT and CCK-8 assay for evaluation of graphene cytotoxicity. RSC Adv. 2015;5(66):53240–4.

Article  CAS  Google Scholar 

Jager T, Vandenbrouck T, Baas J, de Coen WM, Kooijman SALM. A biology-based approach for mixture toxicity of multiple endpoints over the life cycle. Ecotoxicology. 2010;19(2):351–61.

Article  CAS  PubMed  Google Scholar 

Kang L, Lin X, Feng J, Duan M, Duan N, Wang Z, Wu S. Machine learning-assisted multiplexed fluorescence-labeled miRNAs imaging decoding for combined mycotoxins toxicity assessment. Anal Chem. 2025;97(14):8001–10.

Article  CAS  PubMed  Google Scholar 

Gustavsson M, Käll S, Svedberg P, Inda-Diaz JS, Molander S, Coria J, Backhaus T, Kristiansson E. Transformers enable accurate prediction of acute and chronic chemical toxicity in aquatic organisms. Sci Adv. 2024;10(10):eadk6669.

Article  PubMed  PubMed Central  Google Scholar 

He H, Qin G, Xue M, Feng Z, Mao J, Tao W, Chen H, Wang X, Yu D, Huang F. Mitochondrial nanoprobe for precise cellular and drug analysis via graph Neural network. Chem Eng J. 2024;493:152709.

Article  CAS  Google Scholar 

Ning Z, Zhang Y, Zhang S, Lin X, Kang L, Duan N, Wang Z, Wu S. Deep learning-assisted cellular imaging for evaluating acrylamide toxicity through phenotypic changes. Food Chem Toxicol. 2025;200:115401.

Article  CAS  PubMed  Google Scholar 

Chen X, Xun D, Zheng R, Zhao L, Lu Y, Huang J, Wang R, Wang Y. Deep-learning-assisted assessment of DNA damage based on Foci images and its application in high-content screening of lead compounds. Anal Chem. 2020;92(20):14267–77.

Article  CAS  PubMed  Google Scholar 

Zhang XW, Yang YF, Qi GX, Zhai FH, Fei T, Wang JH, Yu YL, Chen S. Rapid and accurate identification of cell phenotypes of different drug mechanisms by using single-cell fluorescence images via deep learning. Anal Chem. 2023;95(20):8113–20.

Article  CAS  PubMed  Google Scholar 

Sfayyih AH, Sulaiman N, Sabry AH. Non-invasive diagnosis of lung diseases via multimodal feature extraction from breathing audio and chest dynamics. Comput Biol Med. 2025;191:110182.

Article  PubMed  Google Scholar 

Vlot AHC, Aniceto N, Menden MP, Ulrich-Merzenich G, Bender A. Applying synergy metrics to combination screening data: Agreements, disagreements and pitfalls. Drug Discov Today. 2019;24(12):2286–98.

Article  CAS  PubMed  Google Scholar 

Cao J, Liu Y, Jia L, Jiang LIP, Geng CY, Yao XF, Kong Y, Jiang BN, Zhong LF. Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric Food Chem. 2008;56(24):12059–63.

Article  CAS  PubMed  Google Scholar 

Zhang L, Yang L, Luo Y, Dong L, Chen F. Acrylamide-induced hepatotoxicity through oxidative stress: Mechanisms and interventions. Antioxid Redox Signal. 2022;38(16–18):1122–37.

Google Scholar 

Lee WJ, Sheu HH, Liu SH, Yi YC, Chen WC, Lin SY, Liang KW, Shen CC, Yeh HY, Lin LY. Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction. Free Radic Biol Med. 2014;74:294–306.

Article  CAS  PubMed  Google Scholar 

Stirling DR, Swain-Bowden MJ, Lucas AM, Carpenter AE, Cimini BA, Goodman A. CellProfiler 4: Improvements in speed, utility and usability. BMC Bioinf. 2021;22(1):433.

Article  Google Scholar