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One-Step In-Situ Synthesis of Porous AuRu Solid-Solution Alloy for Efficient Non-Enzymatic Glucose Sensing Application
One-Step In-Situ Synthesis of Porous AuRu Solid-Solution Alloy for Efficient Non-Enzymatic Glucose Sensing Application
The practicality of the non-enzymatic glucose sensing depends on the development of cost-effective, binder-free, and highl...
Density-Based Resampling Strategy Unveils Metabolic Heterogeneity and Subtypes in Liver Disease Progression
Density-Based Resampling Strategy Unveils Metabolic Heterogeneity and Subtypes in Liver Disease Progression
Metabolomics studies of heterogeneous diseases, such as hepatitis B virus (HBV) infection, liver cirrhosis (LC), and hepat...
Mass Spectrometry-Based Multi-Omics Integration Decodes Metabolic-Immune Crosstalk in Multifocal Breast Cancer Progression
Mass Spectrometry-Based Multi-Omics Integration Decodes Metabolic-Immune Crosstalk in Multifocal Breast Cancer Progression
The heterogeneity in the different primary tumor sites of metabolic-immune networks across multifocal tumors remains a cri...
Cell-Permeable Mitochondrial-Targeting Probes Enable Precise Tracking Via the Interplay between Electrostatic Interaction and Lipid-Tail Anchoring Mechanism
Cell-Permeable Mitochondrial-Targeting Probes Enable Precise Tracking Via the Interplay between Electrostatic Interaction and Lipid-Tail Anchoring Mechanism
Mitochondria constitute vital organelles in eukaryotic cells, essential not only for adenosine triphosphate (ATP) synthesi...
Decoding Soft Metals Multifunctional Fluorescent Probes for Selective Ag and Hg Sensing
Decoding Soft Metals Multifunctional Fluorescent Probes for Selective Ag and Hg Sensing
Ag+ and Hg2+ are soft, thiophilic cations of high environmental and biomedical relevance, yet their closely related coordi...
Portable Microfluidic Detection of via MOF-CRISPR–Cas12a Cascade Signal Amplification
Portable Microfluidic Detection of via MOF-CRISPR–Cas12a Cascade Signal Amplification
Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia, especially in children, but its early diag...
Real-Time Imaging of Pulmonary Inflammation and Smoke-Induced Lung Toxicity via a Near-Infrared Probe Targeting Butyrylcholinesterase Activity
Real-Time Imaging of Pulmonary Inflammation and Smoke-Induced Lung Toxicity via a Near-Infrared Probe Targeting Butyrylcholinesterase Activity
Monitoring pulmonary injury caused by environmental exposures remains a critical challenge in toxicological and diagnostic...
From Sensing to Prediction: A Machine Learning-Enhanced Electrochemical Platform for Ultrasensitive Monitoring of Bioactive Flavonoids
From Sensing to Prediction: A Machine Learning-Enhanced Electrochemical Platform for Ultrasensitive Monitoring of Bioactive Flavonoids
Rutin (Rt) and quercetin (Qt), two prominent bioactive flavonoids, are widely present in functional foods and beverages, o...
A Microcontroller-Integrated Multichannel Time Detector for Paper-Based Analytical Devices — Applications to Viscosity Measurements in Saliva Analysis and Protease-Activity Assays
A Microcontroller-Integrated Multichannel Time Detector for Paper-Based Analytical Devices — Applications to Viscosity Measurements in Saliva Analysis and Protease-Activity Assays
We designed and developed a microcontroller-integrated multichannel time detection system that uses a microfluidic paper-b...
Comparative Evaluation of Three Serum Thawing Methods and Their Effects on Metabolome Integrity and Biomarker Discovery
Comparative Evaluation of Three Serum Thawing Methods and Their Effects on Metabolome Integrity and Biomarker Discovery
Serum samples are widely used in metabolomics studies and are typically stored at −80 °C after collect...
Highly Sensitive Analysis of Iodine in Seawater via Headspace Solid-Phase Microextraction Coupled with Gas Chromatography-Mass Spectrometry
Highly Sensitive Analysis of Iodine in Seawater via Headspace Solid-Phase Microextraction Coupled with Gas Chromatography-Mass Spectrometry
Monitoring iodine speciation in marine environments holds immense significance due to its profound implications for human ...
Multiple miRNA Analysis Based on DNA Fiber Barcodes for Cell Typing
Multiple miRNA Analysis Based on DNA Fiber Barcodes for Cell Typing
Tumor cell subtyping is clinically critical for early cancer diagnosis and prognostic assessment. As key regulators of cel...
Peltier-Based Temperature Control Enables High-Bandwidth and Low-Noise Measurements with Solid-State Nanopores
Peltier-Based Temperature Control Enables High-Bandwidth and Low-Noise Measurements with Solid-State Nanopores
Temperature is a fundamental yet underexploited control parameter in nanopore-based single-molecule sensing, critically in...
Tailored Assembly of Electronically Engineered Gold Nanoclusters for On-Chip Visual Detection of Nitrogen-Rich Heterocyclic Explosives
Tailored Assembly of Electronically Engineered Gold Nanoclusters for On-Chip Visual Detection of Nitrogen-Rich Heterocyclic Explosives
Rapid and reliable detection of emerging nitrogen-rich heterocyclic explosives is essential for security and environmental...
A Robust Magnetic Graphitic Nanozyme Breaking The pH Limitation For Colorimetric Isoniazid Assay in Biosamples
A Robust Magnetic Graphitic Nanozyme Breaking The pH Limitation For Colorimetric Isoniazid Assay in Biosamples
The development of a reliable method for isoniazid (INH) determination is critical for optimizing individualized dosing re...
Electrochemically Converted Dopamine Release Platform for Kinetic Analysis of Ca Responses in Hippocampal Neurons
Electrochemically Converted Dopamine Release Platform for Kinetic Analysis of Ca Responses in Hippocampal Neurons
Chemical signaling molecules mediate intercellular communication and physiological regulation, and their precise spatiotem...
Rabbit-Derived Monoclonal Antibody Based on Single B Cell Technology for Ultra-Sensitive and Specific Detection of Nicosulfuron in Soil and Agricultural Products
Rabbit-Derived Monoclonal Antibody Based on Single B Cell Technology for Ultra-Sensitive and Specific Detection of Nicosulfuron in Soil and Agricultural Products
Nicosulfuron, a sulfonylurea herbicide, is primarily used to control annual weeds in corn fields in China. Residues of nic...
On-site Mass Spectrometry Detection of Exhaled Nitric Oxide Using Modified-Mask Sampling
On-site Mass Spectrometry Detection of Exhaled Nitric Oxide Using Modified-Mask Sampling
Exhaled nitric oxide (NO) is a key biomarker of respiratory diseases and has been widely applied in clinical practice. New...
Employing Deep Learning for the Analysis of Cellular Phenotypic Changes to Assess the Combined Toxicity of Maillard Reaction Products
Employing Deep Learning for the Analysis of Cellular Phenotypic Changes to Assess the Combined Toxicity of Maillard Reaction Products
Acrylamide (AA) and N(6)-carboxymethyllysine (CML) are representative hazardous compounds generated during the Maillard re...
Structural Identification of Emodin Metabolites in Rats After Oral Administration Through Deciphering Positional Isomers
Structural Identification of Emodin Metabolites in Rats After Oral Administration Through Deciphering Positional Isomers
Emodin (Emo) is a primary active component of tartary buckwheat and rhubarb. In this study, we aimed to definitively ident...
Sensitive and Rapid Electrochemiluminescent Detection of Choline Based on Luminol Derivate-Doped Silica Nanoparticles
Sensitive and Rapid Electrochemiluminescent Detection of Choline Based on Luminol Derivate-Doped Silica Nanoparticles
As the key factor in brain development and fat metabolism, choline is widely present in foods, especially in health care a...
Hydrophobic Deep Eutectic Solvent Based Dispersive Liquid–Liquid Microextraction for a Green and Efficient Triclosan Determination: Critical Study of Extraction Variables
Hydrophobic Deep Eutectic Solvent Based Dispersive Liquid–Liquid Microextraction for a Green and Efficient Triclosan Determination: Critical Study of Extraction Variables
A rapid and effective analytical method was developed for the detection of triclosan in wastewater samples using a hydroph...
A Photoelectrochemical Sensor for Glutathione Detection Based on a Target-triggered Etching Strategy
A Photoelectrochemical Sensor for Glutathione Detection Based on a Target-triggered Etching Strategy
A highly efficient photoelectrochemical (PEC) biosensor for glutathione (GSH) assay was constructed based on the target-tr...
A Novel Conjugated Fluorescent Probe and its Application to Nitenpyram Detection
A Novel Conjugated Fluorescent Probe and its Application to Nitenpyram Detection
In this study, a fluorenyl pyridine-based (FPD) conjugated polymer was synthesized and used as a fluorescent probe to effi...
Development of a UHPLC-MS/MS Assay for Determination of Polypropylene Glycol 4 K Polymers Coupled with Micro-Solid Phase Extraction and Selection of [M + NH] Adduct Strategy to Enhance Sensitivity
Development of a UHPLC-MS/MS Assay for Determination of Polypropylene Glycol 4 K Polymers Coupled with Micro-Solid Phase Extraction and Selection of [M + NH] Adduct Strategy to Enhance Sensitivity
A simple analytical assay based on ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) and...
Chemiluminescent Quantification of Trimethylamine Oxide in Seafoods
Chemiluminescent Quantification of Trimethylamine Oxide in Seafoods
Trimethylamine N-oxide (TMAO), a small microbial metabolite, is bioactive and closely related to cardiovascular diseases (...
Activation of Wet-Pulled Carbon Nanotube Fibers for Electrochemical Detection of Dopamine
Activation of Wet-Pulled Carbon Nanotube Fibers for Electrochemical Detection of Dopamine
Carbon nanotube fibers (CNTFs) fabricated using a novel “wet-pulling” technique were evaluated for electrochem...
Typing Brucella Species by MALDI-TOF Mass Spectrometry Combined with Machine Learning
Typing Brucella Species by MALDI-TOF Mass Spectrometry Combined with Machine Learning
Brucellosis is a highly infectious anthropozoonotic disease caused by the genus Brucella, which is the pathogenic bacteria...
On-Line Monitoring of Guizhi Fuling Capsules and Tablets Dissolution Behavior Using Near-Infrared Spectroscopy Combined with Chemometrics
On-Line Monitoring of Guizhi Fuling Capsules and Tablets Dissolution Behavior Using Near-Infrared Spectroscopy Combined with Chemometrics
To validate the feasibility of using near-infrared (NIR) spectroscopy for real-time monitoring of multiple active pharmace...
Direct in situ Measurement of Electrocatalytic Carbon Dioxide Reduction Properties using Scanning Electrochemical Microscopy
Direct in situ Measurement of Electrocatalytic Carbon Dioxide Reduction Properties using Scanning Electrochemical Microscopy
One fundamental question facing electrocatalytic CO2 reduction reaction (CO2RR) is how to identify and correlate the local...
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