Allocati N, Masulli M, Di Ilio C, Federici L (2018) Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases. Oncogenesis 7:8. https://doi.org/10.1038/s41389-017-0025-3
Article CAS PubMed PubMed Central Google Scholar
Bakken TE, Hodge RD, Miller JA, Yao Z, Nguyen TN, Aevermann B et al (2018) Single-nucleus and single-cell transcriptomes compared in matched cortical cell types. PLoS ONE 13:e0209648. https://doi.org/10.1371/JOURNAL.PONE.0209648
Article PubMed PubMed Central Google Scholar
Baligács N, Albertini G, Borrie SC, Serneels L, Pridans C, Balusu S et al (2024) Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s disease. Nat Commun 15:10634. https://doi.org/10.1038/s41467-024-54779-w
Article CAS PubMed PubMed Central Google Scholar
Bemiller SM, McCray TJ, Allan K, Formica SV, Xu G, Wilson G et al (2017) TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy. Mol Neurodegener 12:1–12. https://doi.org/10.1186/S13024-017-0216-6
Bhattacherjee A, Jung J, Zia S, Ho M, Eskandari-Sedighi G, Laurent CD et al (2021) The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia. Mol Neurodegener 16(1):19. https://doi.org/10.1186/s13024-021-00443-6
Article CAS PubMed PubMed Central Google Scholar
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259. https://doi.org/10.1007/BF00308809
Article CAS PubMed Google Scholar
Brown GC, St George-Hyslop P (2022) Does soluble TREM2 protect against Alzheimer’s disease? Front Aging Neurosci. https://doi.org/10.3389/fnagi.2021.834697
Article PubMed PubMed Central Google Scholar
Caramello A, Fancy N, Tournerie C, Eklund M, Chau V, Adair E et al (2025) Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease. Nat Commun 16:5189. https://doi.org/10.1038/s41467-025-60328-w
Article CAS PubMed PubMed Central Google Scholar
Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV et al (2013) Enrichr interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform 14(1):128. https://doi.org/10.1186/1471-2105-14-128
Cousin E, Hannequin D, Ricard S, Macé S, Génin E, Chansac C et al (2003) A risk for early-onset Alzheimer’s disease associated with the APBB1 gene (FE65) intron 13 polymorphism. Neurosci Lett 342:5–8. https://doi.org/10.1016/S0304-3940(03)00225-8
Article CAS PubMed Google Scholar
Daschil N, Obermair GJ, Flucher BE, Stefanova N, Hutter-Paier B, Windisch M et al (2013) CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of Amyloid-β plaques in an Alzheimer’s disease mouse model. J Alzheimers Dis 37:439–451. https://doi.org/10.3233/JAD-130560
Article CAS PubMed PubMed Central Google Scholar
Du F, Yu Q, Yan S, Zhang Z, Vangavaragu JR, Chen D et al (2021) Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer’s disease. Aging Cell 20:e13368. https://doi.org/10.1111/acel.13368
Article CAS PubMed PubMed Central Google Scholar
Escartin C, Galea E, Lakatos A, O’Callaghan JP, Petzold GC, Serrano-Pozo A et al (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci 24(3):312–325. https://doi.org/10.1038/s41593-020-00783-4
Article CAS PubMed PubMed Central Google Scholar
Eskandari-Sedighi G, Crichton M, Zia S, Gomez-Cardona E, Cortez LM, Patel ZH et al (2024) Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice. Mol Neurodegenerat 19(1):42. https://doi.org/10.1186/s13024-024-00734-8
Leyns CE, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H et al (2019) TREM2 function impedes tau seeding in neuritic plaques. Nature Neurosci 22(8):1217–1222. https://doi.org/10.1038/s41593-019-0433-0
Article CAS PubMed PubMed Central Google Scholar
Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B et al (2023) Early Alzheimer’s disease pathology in human cortex involves transient cell states. Cell 186:4438. https://doi.org/10.1016/j.cell.2023.08.005
Article CAS PubMed PubMed Central Google Scholar
Gratuze M, Leyns CEG, Holtzman DM (2018) New insights into the role of TREM2 in Alzheimer ’ s disease. Mol Neurodegener 13(1):66
Article CAS PubMed PubMed Central Google Scholar
Griciuc A, Patel S, Federico AN, Choi SH, Innes BJ, Oram MK et al (2019) TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease. Neuron 103:820-835.e7. https://doi.org/10.1016/j.neuron.2019.06.010
Article CAS PubMed PubMed Central Google Scholar
Griffiths J, Schneegans E, Whitwell H, Qiu Z, Notman B, Cheung D, Willumsen N, Matthews PM, Grant SGN, Jackson JS (2025) A synaptic-astrocytic proteomic signature associated with synaptopathy in Alzheimer’s Disease. 2025.01.23.634408
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E et al (2012) TREM2 Variants in Alzheimer’s Disease. New Eng J Med 368:117–127. https://doi.org/10.1056/nejmoa1211851
Article PubMed PubMed Central Google Scholar
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J-C, Carrasquillo MM et al (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease. Nat Genet 43:429–435. https://doi.org/10.1038/ng.803
Article CAS PubMed PubMed Central Google Scholar
Hunter S, Brayne C (2017) Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research? J Negat Results BioMed 16:1. https://doi.org/10.1186/s12952-017-0066-3
Article PubMed PubMed Central Google Scholar
Jay TR, von Saucken VE, Muñoz B, Codocedo JF, Atwood BK, Lamb BT et al (2019) TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia 67:1873–1892. https://doi.org/10.1002/GLIA.23664
Jin SC, Benitez BA, Karch CM, Cooper B, Skorupa T, Carrell D et al (2014) Coding variants in TREM2 increase risk for Alzheimer’s disease. Hum Mol Genet 23:5838–5846. https://doi.org/10.1093/HMG/DDU277
Comments (0)