SCI Abstract

search
+
ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis
ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, most sporadic cases exhibiting TAR DNA-binding ...
Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE)
Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE)
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neurodegenerative disease marked by TDP-43 proteinopathy,...
Frequency of mixed neuropathologies in individuals with Down syndrome with and without Alzheimer's dementia
Frequency of mixed neuropathologies in individuals with Down syndrome with and without Alzheimer's dementia
Individuals with Down syndrome (DS) develop Alzheimer's disease neuropathological change (ADNC) by the age of 40&n...
Future directions in the treatment of brain metastases: evaluating the role of cellular players in the tumour microenvironment
Future directions in the treatment of brain metastases: evaluating the role of cellular players in the tumour microenvironment
Recent clinical trials have demonstrated the efficacy of different modalities of systemic therapy in treating brain metast...
A plasma protein signature for cerebral amyloid angiopathy
A plasma protein signature for cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the deposition of amyloid-β (Aβ...
The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex
The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in TSC1 and TSC2, resulting in activation of mechan...
Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration
Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration
Alzheimer disease neuropathologic change (ADNC) is considered to be the most common cause of cognitive decline and dementi...
and fusions in non-vestibular intracranial schwannomas
and fusions in non-vestibular intracranial schwannomas
Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G et al (2016) The genomic landscape of schwannoma. Nat Genet...
Reevaluating the role of beta2-microglobulin: new insights on selective vulnerability in ALS pathology
Reevaluating the role of beta2-microglobulin: new insights on selective vulnerability in ALS pathology
Amyotrophic lateral sclerosis (ALS) is characterized by the selective loss of motor neurons (MNs). Why these neurons are p...
GRP78 associates with alpha-synuclein in vulnerable neurons of the Parkinson’s disease brain
GRP78 associates with alpha-synuclein in vulnerable neurons of the Parkinson’s disease brain
Conflict of interest The authors declare no competing inter...
AETA peptide contributes to Alzheimer’s disease signature of synapse dysfunction
AETA peptide contributes to Alzheimer’s disease signature of synapse dysfunction
Alzheimer’s disease (AD), the leading cause of dementia, is characterized by early synaptic dysfunction that precede...
Expression of GPR34 in microglia remains stable in human Alzheimer’s disease
Expression of GPR34 in microglia remains stable in human Alzheimer’s disease
Microglia are the resident immune cells of the human central nervous system and play key roles in development, homeostasis...
Mechanisms of increased Alzheimer’s disease pathology with and variants
Mechanisms of increased Alzheimer’s disease pathology with and variants
TREM2 plays multiple functional roles in microglia and variants are associated with increased risks of Alzheimer’s d...
Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer’s disease
Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer’s disease
Fluid and imaging biomarker data show that anti-amyloid (Aβ) antibodies promote the clearance of Aβ from the bra...
CTE has multiple pathologic variants that might relate to different clinical symptom presentation
CTE has multiple pathologic variants that might relate to different clinical symptom presentation
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease found in individuals with a history of r...
Risk stratification for meningiomas with discordant molecular classification
Risk stratification for meningiomas with discordant molecular classification
Bayley JC, Hadley CC, Harmanci AO, Harmanci AS, Klisch TJ, Patel AJ (2022) Multiple approaches converge on three biologica...
Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP
Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP
Across tauopathies—Alzheimer’s disease (AD), frontotemporal lobar degeneration due to tau (FTLD-tau)—we ...
Donor-specific pathological features associate with genetic background, lesion type distribution, and clinical heterogeneity in multiple sclerosis
Donor-specific pathological features associate with genetic background, lesion type distribution, and clinical heterogeneity in multiple sclerosis
Multiple sclerosis (MS) shows pronounced pathological and clinical variability between individuals, reflecting differences...
VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy
VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy
X-Linked myopathy with excessive autophagy (XMEA) is a rare vacuolar myopathy caused by mutations in Vma21, an assembly ch...
Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity
Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity
Mesial temporal lobe epilepsy (mTLE) is a subtype of focal epilepsy in which approximately one-third of patients develop p...
Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
The SH3PXD2A-HTRA1 fusion gene has recently been identified in a subset of schwannomas, but its frequency and clinical sig...
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Oligodendroglial alpha-synuclein (aSyn) deposits are a key feature in the atypical parkinsonian disorder, multiple system ...
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
DNA methylation-based classification using the Heidelberg Classifier is a state-of-the-art data-driven method for molecula...
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer’s disease (AD), also occu...
Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas
Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas
Both spinal ependymomas (SPE) and myxopapillary ependymomas (MPE) exhibit a character...
Evolution of pilocytic astrocytoma to diffuse leptomeningeal glioneuronal tumor (DLGNT): bridging two distinct tumor types
Evolution of pilocytic astrocytoma to diffuse leptomeningeal glioneuronal tumor (DLGNT): bridging two distinct tumor types
DCM and JC receive support from the St. Jude Comprehensive Cancer Center (NCI grant P30CA021765) and American Lebanese Syr...
Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease
Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease
Disturbances within the cerebrovascular system substantially contribute to the pathogenesis of age-related cognitive impai...
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells
Tumor-associated macrophages (TAMs) represent the main immune cell population in various brain malignancies, but there is ...
Primary age-related tauopathy
Primary age-related tauopathy
Primary age-related tauopathy (PART) was proposed in 2014 as a neuropathological term to describe patients with Alzheimer&...
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM
Diffuse midline glioma (DMG; a subtype of pediatric high-grade glioma) is a fatal disease in children, due to the localiza...
Load More
format_indent_increase