Hinderer S, Schenke-Layland K. Cardiac fibrosis - A short review of causes and therapeutic strategies. Adv Drug Deliver Rev. 2019;146:77–82.
Adao DMT, Ching C, Fish JE, Simmons CA, Billia F. Endothelial cell-cardiomyocyte cross-talk: understanding bidirectional paracrine signaling in cardiovascular homeostasis and disease. Clin Sci. 2024;138:1395–419.
Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G. Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review. J Am Heart Assoc. 2019;73:190–209.
Wang Z, Stuckey DJ, Murdoch CE, Camelliti P, Lip GYH, Griffin M. Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor. Cell Death Dis. 2018;9:613.
Article PubMed PubMed Central Google Scholar
Zhang GH, Yu FC, Li Y, Wei Q, Song SS, Zhou FP. Prolyl 4-hydroxylase domain protein 3 overexpression improved obstructive sleep apnea-induced cardiac perivascular fibrosis partially by suppressing endothelial-to-mesenchymal transition. J Am Heart Assoc. 2017;6:e006680.
Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007;13:952–61.
Article CAS PubMed Google Scholar
Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M. Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun. 2021;12:681.
Article CAS PubMed PubMed Central Google Scholar
Alemasova EE, Lavrik OI. Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins. Nucleic Acids Res. 2019;47:3811–27.
Article CAS PubMed PubMed Central Google Scholar
Jagtap P, Szabó C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005;4:421–40.
Article CAS PubMed Google Scholar
Li Z, Guo Z, Lan R, Cai S, Lin Z, Li J. The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy. Acta Pharmacol Sin B. 2021;11:1286–99.
Lu J, Zhang R, Hong H, Yang Z, Sun D, Sun S, et al. The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy. Biochim Biophys Acta Biomembr. 2016;1863:3027–39.
Wang L, Li Z, Tan Y, Li Q, Yang H, Wang P. PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy. Mol Cel Endocrinol. 2018;474:137–50.
Li Q, Li ZM, Sun SY, Wang LP, Wang PX, Guo Z. PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy. Acta Pharmacol Sin. 2019;40:589–98.
Article CAS PubMed Google Scholar
Wang L, Wang P, Xu S, Li Z, Duan DD, Ye J. The cross-talk between PARylation and SUMOylation in C/EBPβ at K134 site participates in pathological cardiac hypertrophy. Int J Biol Sci. 2022;18:783–99.
Article CAS PubMed PubMed Central Google Scholar
Fan M, Yang K, Wang X, Chen L, Gill PS, Ha T. Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction. Sci Adv. 2023;9:eadc9465.
Article CAS PubMed PubMed Central Google Scholar
Li J, Zhang Y, Li C, Xie J, Liu Y, Zhu W. HSPA12B attenuates cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism. Cardiovas Res. 2013;99:674–84.
He Y, Li S, Jiang L, Wu K, Chen S, Su L. Palmitic acid accelerates endothelial cell injury and cardiovascular dysfunction via palmitoylation of PKM2. Adv Sci. 2025;12:e2412895.
Kuno A, Hosoda R, Tsukamoto M, Sato T, Sakuragi H, Ajima N. SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX. Cardiovasc Res. 2023;118:3360–73.
Wang J, Niu N, Xu S, Jin ZG. A simple protocol for isolating mouse lung endothelial cells. Sci Rep-UK. 2019;9:1458.
Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR. A metabolic basis for endothelial-to-mesenchymal transition. Mol Cell. 2018;69:689–98.
Article CAS PubMed PubMed Central Google Scholar
Vilar E, Bartnik CM, Stenzel SL, Raskin L, Ahn J, Moreno V. MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. Cancer Res. 2011;71:2632–42.
Article CAS PubMed PubMed Central Google Scholar
Tai S, Sun J, Zhou Y, Zhu Z, He Y, Chen M. Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux. J Adv Res. 2022;41:205–18.
Article CAS PubMed Google Scholar
Mao J, Wang D, Wang D, Wu Q, Shang Q, Gao C. SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis. Exp Mol Med. 2023;55:253–68.
Article CAS PubMed PubMed Central Google Scholar
Liu T, Zhou L, Yang K, Iwasawa K, Kadekaro AL, Takebe T. The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal Transduct Target Ther. 2019;4:63.
Article CAS PubMed PubMed Central Google Scholar
Zhai KF, Zheng JR, Tang YM, Li F, Lv YN, Zhang YY. The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis. Br J Pharmacol. 2017;174:2818–31.
Wu J, Gou W, Wang Z, Chang H, Li D, Hou W. Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosis in vitro and in vivo. Acta Pharmacol Sin B. 2023;13:1216–30.
Amrute JM, Luo X, Penna V, Yang S, Yamawaki T, Hayat S. Targeting immune-fibroblast cell communication in heart failure. Nature. 2024;635:423–33.
Article CAS PubMed PubMed Central Google Scholar
Maciejak A, Kiliszek M, Michalak M, Tulacz D, Opolski G, Matlak K. Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure. Genome Med. 2015;7:26.
Article PubMed PubMed Central Google Scholar
Koenig AL, Shchukina I, Amrute J, Andhey PS, Zaitsev K, Lai L. Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure. Nat Cardiovasc Res. 2022;1:263–80.
Article CAS PubMed PubMed Central Google Scholar
Qaqorh T, Takahashi Y, Sameshima K, Otani K, Yazawa I, Nishida Y. Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by spatial and single-cell transcriptomics. Sci Adv. 2025;11:eadq1575.
Article CAS PubMed PubMed Central Google Scholar
Chiu SP, Camacho CV, Kraus WL. Development and characterization of recombinant ADP-ribose binding reagents that allow simultaneous detection of mono and poly ADP-ribose. J Biol Chem. 2024;300:107609.
Article CAS PubMed PubMed Central Google Scholar
Gao A, Su Z, Shang Z, He C, Miao D, Li X. TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner. Cell Death Dis. 2022;13:900.
Article CAS PubMed PubMed Central Google Scholar
Shi M, Cui H, Shi J, Mei Y. Silencing FHL2 inhibits bleomycin-induced pulmonary fibrosis through the TGF-β1/Smad signaling pathway. Exp Cell Res. 2023;423:113470.
Comments (0)