Achkar JM, Chan J and Casadevall A 2015 B cells and antibodies in the defense against Mycobacterium tuberculosis infection. Immunol. Rev. 264 167–181

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahmed A, Dolasia K and Mukhopadhyay S 2018 Mycobacterium tuberculosis PPE18 protein reduces inflammation and increases survival in animal model of sepsis. J. Immunol. 200 3587–3598

Article  PubMed  CAS  Google Scholar 

Allman D and Pillai S 2008 Peripheral B cell subsets. Curr. Opin. Immunol. 20 149–157

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bekeredjian-Ding I and Jego G 2009 Toll-like receptors – sentries in the B-cell response. Immunology 128 311–323

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bhat KH, Ahmed A, Kumar S, et al. 2012 Role of PPE18 protein in intracellular survival and pathogenicity of Mycobacterium tuberculosis in mice. PLoS One 7 e52601

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bosio CM, Gardner D and Elkins KL 2000 Infection of B cell-deficient mice with CDC 1551, a clinical isolate of Mycobacterium tuberculosis: delay in dissemination and development of lung pathology. J. Immunol. 164 6417–6425

Article  PubMed  CAS  Google Scholar 

Chen X, Cheng HF, Zhou J, et al. 2017 Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis. J. Biol. Chem. 292 16880–16890

Article  PubMed  PubMed Central  CAS  Google Scholar 

Choreño-Parra JA, Bobba S, Rangel-Moreno J, et al. 2020 Mycobacterium tuberculosis HN878 infection induces human-like B-cell follicles in mice. J. Infect. Dis. 221 1636–1646

Article  PubMed  PubMed Central  Google Scholar 

Cole ST, Brosch R, Parkhill J, et al. 1998 Deciphering the biology of Mycobacterium tuberculosis from the complete genome. Nature 393 537–544

Article  PubMed  CAS  Google Scholar 

Dolasia K, Nazar F and Mukhopadhyay S 2021 Mycobacterium tuberculosis PPE18 protein inhibits MHC class II antigen presentation and B cell response in mice. Eur. J. Immunol. 51 603–619

Article  PubMed  CAS  Google Scholar 

Ehrenstein MR and Notley CA 2010 The importance of natural IgM: scavenger, protector and regulator. Nat. Rev. Immunol. 10 778–786

Article  PubMed  CAS  Google Scholar 

Gey van Pittius NC, Sampson SL, Lee H, et al. 2006 Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions. BMC Evol. Biol. 6 95

Article  PubMed  PubMed Central  Google Scholar 

Global tuberculosis report 2024 Geneva: World Health Organization https://iris.who.int/bitstream/handle/10665/379339/9789240101531-eng.pdf?sequence=1

Goudie MJ, Brisbois EJ, Pant J, et al. 2016 Characterization of an S-nitroso-N-acetylpenicillamine-based nitric oxide releasing polymer from a translational perspective. Int. J. Polym. Mater. 65 769–778

Article  PubMed  PubMed Central  CAS  Google Scholar 

Harada Y, Miyamoto K and Sujino T 2022 Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction. STAR Protoc. 3 101728

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jacobs MD and Morrison DC 1975 Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen. J. Exp. Med. 141 1453–1458

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jang AR, Kim G, Hong JJ, et al. 2019 Mycobacterium tuberculosis ESAT6 drives the activation and maturation of bone marrow-derived dendritic cells via TLR4-mediated signaling. Immune Netw. 19 e13

Article  PubMed  PubMed Central  Google Scholar 

Kozakiewicz L, Phuah J, Flynn J, et al. 2013 The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Adv. Exp. Med. Biol. 783 225–250

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee MR, Seo GY, Kim YM, et al. 2011 iNOS potentiates mouse Ig isotype switching through AID expression. Biochem. Biophys. Res. Commun. 410 602–607

Article  PubMed  CAS  Google Scholar 

Maglione PJ and Chan J 2009 How B cells shape the immune response against Mycobacterium tuberculosis. Eur. J. Immunol. 39 676–686

Article  PubMed  PubMed Central  CAS  Google Scholar 

Maglione PJ, Xu J and Chan J 2007 B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J. Immunol. 178 7222–7234

Article  PubMed  CAS  Google Scholar 

Mukhopadhyay S and Balaji KN 2011 The PE and PPE proteins of Mycobacterium tuberculosis. Tuberculosis 91 441–447

Article  PubMed  CAS  Google Scholar 

Mukhopadhyay S, George A, Bal V, et al. 1999 Bruton’s tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction. J. Immunol. 163 1786–1792

Article  PubMed  CAS  Google Scholar 

Muramatsu M, Kinoshita K, Fagarasan S, et al. 2000 Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 553–563

Article  PubMed  CAS  Google Scholar 

Nair S, Ramaswamy PA, Ghosh S, et al. 2009 The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage. J. Immunol. 183 6269–6281

Article  PubMed  CAS  Google Scholar 

Nair S, Pandey AD and Mukhopadhyay S 2011 The PPE18 protein of Mycobacterium tuberculosis inhibits NF-κB/rel-mediated proinflammatory cytokine production by upregulating and phosphorylating suppressor of cytokine signaling 3 protein. J. Immunol. 186 5413–5424

Article  PubMed  CAS  Google Scholar 

Obukhanych TV and Nussenzweig MC 2006 T-independent type II immune responses generate memory B cells. J. Exp. Med. 203 305–310

Article  PubMed  PubMed Central  Google Scholar 

Pal R, Ghosh S and Mukhopadhyay S 2021 Moonlighting by PPE2 protein: Focus on mycobacterial virulence. J. Immunol. 207 2393–2397

Article  PubMed  CAS  Google Scholar 

Pal R, Bisht MK and Mukhopadhyay S 2022 Secretory proteins of Mycobacterium tuberculosis and their roles in modulation of host immune responses: focus on therapeutic targets. FEBS J. 289 4146–4171

Article  PubMed  CAS  Google Scholar 

Park J, Kim H, Kwon KW, et al. 2020 Toll-like receptor 4 signaling-mediated responses are critically engaged in optimal host protection against highly virulent Mycobacterium tuberculosis K infection. Virulence 11 430–445

Article  PubMed  PubMed Central  CAS  Google Scholar 

Phuah JY, Mattila JT, Lin PL, et al. 2012 Activated B cells in the granulomas of nonhuman primates infected with Mycobacterium tuberculosis. Am. J. Pathol. 181 508–514