Al Naggar Y, Baer B (2019) Consequences of a short time exposure to a sublethal dose of flupyradifurone (Sivanto) pesticide early in life on survival and immunity in the honeybee (Apis mellifera). Sci Rep 9:19753. https://doi.org/10.1038/s41598-019-56224-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

An H, Landis JT, Bailey AG, Marron JS, Dittmer DP (2019) Dr4pl: a stable convergence algorithm for the 4 parameter logistic model. R J 11:171–190. https://doi.org/10.32614/RJ-2019-003

Article  Google Scholar 

Bartlett AJ, Hedges AM, Intini KD, Brown LR, Maisonneuve FJ, Robinson SA, Gillis PL, de Solla SR (2018) Lethal and sublethal toxicity of neonicotinoid and butenolide insecticides to the mayfly, Hexagenia spp. Environ Pollut 238:63–75. https://doi.org/10.1016/j.envpol.2018.03.004

Article  CAS  PubMed  Google Scholar 

Bass C, Denholm I, Williamson MS, Nauen R (2015) The global status of insect resistance to neonicotinoid insecticides. Pestic Biochem Physiol 121:78–87. https://doi.org/10.1016/j.pestbp.2015.04.004

Article  CAS  PubMed  Google Scholar 

Blacquière T, Smagghe G, Van Gestel CAM, Mommaerts V (2012) Neonicotinoids in bees: a review on concentrations, side-effects and risk assessment. Ecotoxicology 21:973–992. https://doi.org/10.1007/s10646-012-0863-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buckingham SD, Lapied B, Le Corronc HL, Grolleau F, Sattelle DB (1997) Imidacloprid actions on insect neuronal acetylcholine receptors. J Exp Biol 200:2685–2692. https://doi.org/10.1242/jeb.200.21.2685

Article  CAS  PubMed  Google Scholar 

Cardoso P, Barton PS, Birkhofer K et al (2020) Scientists’ warning to humanity on insect extinctions. Biol Conserv 242:108426. https://doi.org/10.1016/j.biocon.2020.108426

Article  Google Scholar 

Casida JE (2018) Neonicotinoids and other insect nicotinic receptor competitive modulators: progress and prospects. Annu Rev Entomol 63:125–144. https://doi.org/10.1146/annurev-ento-020117

Article  CAS  PubMed  Google Scholar 

Christian M, Kraft M, Wilknitz P, Nowotny M, Schöneich S (2025) Flupyradifurone, imidacloprid and clothianidin disrupt the auditory processing in the locust CNS. J Comp Physiol A 211:311–325. https://doi.org/10.1007/s00359-025-01735-8

Article  CAS  Google Scholar 

Clemens J, Schöneich S, Kostarakos K, Hennig RM, Hedwig B (2021) A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets. eLife 10:e61475. https://doi.org/10.7554/eLife.61475

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cook DL, Schwindt PC, Grande LA, Spain WJ (2003) Synaptic depression in the localization of sound. Nature 421:66–70. https://doi.org/10.1038/nature01248

Article  CAS  PubMed  Google Scholar 

Dentzman K, Franklin D, Avemegah E, Goldberger JR (2025) An overview of agricultural neonicotinoid regulation in the EU, Canada, and the United States. Pest Manag Sci. https://doi.org/10.1002/ps.70126

Desneux N, Decourtye A, Delpuech JM (2007) The sublethal effects of pesticides on beneficial arthropods. Annu Rev Entomol 52:81–106. https://doi.org/10.1146/annurev.ento.52.110405.091440

Article  CAS  PubMed  Google Scholar 

Dong Y, Zhang Y, An B, Yuan W, Smagghe G, Qin Q, He Y, Wang D (2026) Integrating physiology, behavior, and transcriptomics to refine pesticide risk assessment: the case of flupyradifurone and Coccinella septempunctata. J Pest Sci 99(2):62. https://doi.org/10.1007/s10340-026-02022-4

Article  CAS  Google Scholar 

FAO (2024) Pesticides use and trade, 1990–2022. FAOSTAT AnalyticalBriefs, No 89. Rome. https://doi.org/10.4060/cd1486en

Faulkes Z, Pollack GS (2000) Effects of inhibitory timing on contrast enhancement in auditory circuits in crickets (Teleogryllus oceanicus). J Neurophysiol 84:1247–1255

Article  CAS  PubMed  Google Scholar 

Faulkes Z, Pollack GS (2001) Mechanisms of frequency-specific responses of omega neuron 1 in crickets (Teleogryllus oceanicus): a polysynaptic pathway for song? J Exp Biol 204:1295–1305

Article  CAS  PubMed  Google Scholar 

Fischer LR, Ramesh D, Weidenmüller A (2023) Sub-lethal but potentially devastating—the novel insecticide flupyradifurone impairs collective brood care in bumblebees. Sci Total Environ 903:166097. https://doi.org/10.1016/j.scitotenv.2023.166097

Article  CAS  PubMed  Google Scholar 

Fullard JH, Ratcliffe JM, Guignion C (2005) Sensory ecology of predator-prey interactions: responses of the AN2 interneuron in the field cricket, Teleogryllus oceanicus to the echolocation calls of sympatric bats. J Comp Physiol A 191:605–618. https://doi.org/10.1007/s00359-005-0610-3

Article  Google Scholar 

Gao Z, Ji L, Luo W, Feng Z, Leng X, Ma Y, Wei Y, Pang S, An D, Lu H (2026) Neonicotinoids disrupt flight, bioenergetic homeostasis and neurotransmission in honey bees. J Hazard Mater 506:141620. https://doi.org/10.1016/j.jhazmat.2026.141620

Article  CAS  PubMed  Google Scholar 

Godfray HCJ, Blacquière T, Field LM, Hails RS, Petrokofsky G, Potts SG, Raine NE, Vanbergen AJ, McLean AR (2014) A restatement of the natural science evidence base concerning neonicotinoid insecticides and insect pollinators. Proc Roy Soc B 281:20140558. https://doi.org/10.1098/rspb.2014.0558

Article  Google Scholar 

Góngora-Gamboa C, Ruiz-Sánchez E, Zamora-Bustillos R, Hernandez-Nunez E, Ballina-Gomez H (2025) Lethal and sublethal effects of flupyradifurone and cyantraniliprole on two neotropical stingless bee species. Ecotoxicology 34:456–466. https://doi.org/10.1007/s10646-024-02848-7

Article  CAS  PubMed  Google Scholar 

Hallmann CA, Sorg M, Jongejans E, Siepel H, Hofland N, Schwan H, Stenmans W, Müller A, Sumser H, Hörren T, Goulson D, de Kroon H (2017) More than 75% decline over 27 years in total flying insect biomass in protected areas. PLoS ONE 12:e0185809. https://doi.org/10.1371/journal.pone.0185809

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hedwig B (2006) Pulses, patterns and paths: neurobiology of acoustic behaviour in crickets. J Comp Physiol A 192:677–689

Article  Google Scholar 

Hennig RM (1988) Ascending auditory interneurons in the cricket Teleogryllus commodus (Walker): comparative physiology and direct connections with afferents. J Comp Physiol A 163:135–143. https://doi.org/10.1007/BF00612003

Article  CAS  PubMed  Google Scholar 

Hesselbach H, Scheiner R (2018) Effects of the novel pesticide flupyradifurone (Sivanto) on honeybee taste and cognition. Sci Rep 8:4954. https://doi.org/10.1038/s41598-018-23200-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hesselbach H, Scheiner R (2019) The novel pesticide flupyradifurone (Sivanto) affects honeybee motor abilities. Ecotoxicology 28:354–366. https://doi.org/10.1007/s10646-019-02028-y

Article  CAS  PubMed  Google Scholar 

Hesselbach H, Seeger J, Schilcher F, Ankenbrand M, Scheiner R, Beggs J (2020) Chronic exposure to the pesticide flupyradifurone can lead to premature onset of foraging in honeybees Apis mellifera. J Appl Ecol 57:609–618. https://doi.org/10.1111/1365-2664.13555

Article  CAS  Google Scholar 

Hildebrandt KJ, Benda J, Hennig RM (2009) The origin of adaptation in the auditory pathway of locusts is specific to cell type and function. J Neurosci 29:2626–2636. https://doi.org/10.1523/JNEUROSCI.4800-08.2009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirtz R, Wiese K (1997) Ultrastructure of synaptic contacts between identified neurons of the auditory pathway in Gryllus bimaculatus DeGeer. J Comp Neurol 386:347–357

Article  CAS  PubMed  Google Scholar 

Horseman G, Huber F (1994) Sound iocalisation in crickets: I. Contralateral inhibition of an ascending auditory interneuron (AN1) in the cricket Gryllus bimaculatus. J Comp Physiol A 175:389–398. https://doi.org/10.1007/BF00199247

Article