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Che-Yi Chao, Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 41354, Taiwan, Woei-Cheang Shyu, Graduate Institute of Biomedical Science, China Medical University, Taichung 40604, Taiwan Chih-Lung Lin, Department of Neurosurgery, Asia University Hospital, Taichung 41354, Taiwan En-Pei Isabel Chiang, Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402, Taiwan Yueh-Hsiung Kuo, Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, 19 China Medical University, Taichung 40604 Feng-Yao Tang, China Medical University Taichung, TAIWANFollow Abstract
Background: Over recent decades, considerable attention has been directed toward the discovery of novel compounds capable of targeting survival-related signaling networks as therapeutic candidates for triple-negative breast cancer (TNBC). Central to TNBC pathobiology are the Akt/mTOR and MAPK/ERK signaling axes, both contribute to tumor progression and therapeutic resistance. Caffeic acid (CA), a naturally derived phenolic compound with anti-inflammatory activity, has previously been investigated for its anti-cancer potential. Purpose: In the present study, we explored the therapeutic value of newly synthesized CA derivatives in TNBC models using both cellular and animal-based systems. Methods: The anti-tumor efficacy of these CA derivatives was examined through a series of functional assays, including cell proliferation, clonogenicity, cell cycle profiling, apoptosis quantification, ELISA, western blotting, and histopathological analysis. Results: Among the tested derivatives, decyl caffeate (DC) demonstrated the most pronounced inhibitory effects on TNBC cell growth, significantly decreasing viability, colony formation, and enhancing cisplatin responsiveness (P
Recommended Citation
Chao, Che-Yi; Shyu, Woei-Cheang; Lin, Chih-Lung; Chiang, En-Pei Isabel; Kuo, Yueh-Hsiung; and Tang, Feng-Yao
(2026)
"Decyl caffeate inhibits the proliferation of human triple-negative breast cancer cells,"
BioMedicine: Vol. 16
:
Iss.
1
, Article 4.
DOI: 10.37796/2211-8039.1695
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