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Circadian Rhythms and Neuroendocrine Dysregulation in ADHD: Therapeutic Insights from Omega-3 Fatty Acids
Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition often accompanied by circadian rh...
Tai Chi for Cardiovascular Wellness: Integrating an Ancient Practice into Modern Therapeutic Approaches
Tai Chi, a traditional Chinese martial art characterized by gentle, fluid movements and deep breathing, has gained increas...
Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Monotherapy in Preventing Recurrent Major Depressive Disorder: A Randomized Controlled Trial
Background: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have demonstrated efficacy as adjunctive treatment for MDD. In...
Neuroprotection of paeoniflorin as antidepressant candidate
Background: Depression is one of the common mental disorders worldwide, and currently used antidepressants have undesirabl...
Genetic variations in extracellular matrix degradation pathways linking to major depressive disorder: Evidence from a large-scale genetic association study
Dysregulation of extracellular matrix (ECM) degradation pathways has been increasingly implicated in major depressive diso...
Increased dairy product consumption is associated with shorter telomere length in buccal cells among normotensive adults
Background: Telomere length (TL) is a biomarker of biological aging and a predictor of age-related diseases. Dietary patte...
Chinese herbal medicine treatment and the association with long-term major adverse cardiac events in patients with chronic kidney disease: A propensity-score matched cohort study
Background: Cardiovascular disease (CVD) represents the leading cause of mortality among idividuals with chronic kidney di...
The association between the GNB3 rs5443 C/C genotype and obesity phenotypes in Taiwanese individuals
Background: The prevalence of obesity has increased significantly over the years, and its health concerns cannot be undere...
Decyl caffeate inhibits the proliferation of human triple-negative breast cancer cells
Background: Over recent decades, considerable attention has been directed toward the discovery of novel compounds capable ...
Assessing the capabilities of AI-based large language models (AI-LLMs) in interpreting histopathological slides and scientific figures: performance evaluation study
Background: Integrating artificial intelligence-based large language models (AI-LLMs) into medical and other scientific do...
A glimpse into the impact of physical activity on linear growth in children and adolescents through activity restrictions accompanying the COVID-19 outbreak
Background: Linear growth in children and adolescents, a key health indicator, is influenced by various factors, including...
Neurosurgical Management of Pineal Lesions: Insights from a Single-Center Study of 27 Cases
Introduction: Pineal lesions are rare and surgically challenging due to their deep location, histological diversity, and p...
Adjunctive Hyperbaric Oxygen Therapy for Chronic Diabetic Foot Ulcer Unresponsive to Standard Care: A Case Report
Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus and are often challenging to treat...
Hepatoprotective Evaluation of Benzoylated Emodin Derivatives: Integrating Bioinformatics and In Vitro Studies
Background: Emodin exhibits various pharmacological activities, including hepatoprotective effects. However, its clinical ...
Impacts of DNA ligase I genotypes on Taiwan Parkinson’s disease
Introduction: Genetic polymorphisms in DNA repair pathways can modulate DNA repair capacity and influence susceptibility t...
Evaluation of Bai-Zhu (Atractylodes macrocephala)-Based Herbal Formulae in Breast Cancer: Implications for Metastasis via Zeb1 and Slug Modulation
Background: Bai-Zhu (Atractylodes macrocephala Koidz. [Asteraceae]) is classified in traditional Chinese medicine (TCM) as...
Traditional Chinese herbal medicines suppress endometriosis development through modulating macrophage-mediated immune responses in the peritoneal cavity
Background: Due to unique dietary culture, Asian patients with endometriosis usually seek assistance through traditional C...
Unveiling immune-related gene signatures in triple negative breast cancer through integrated transcriptomic analysis
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options and poor prognosi...
The adverse effects of clozapine on blood markers and electrocardiographic findings in patients with schizophrenia
Introduction: Clozapine remains the gold-standard antipsychotic for treatment-resistant schizophrenia, but its use is hind...
Early life exposure to antibiotics increases the risk of myopia: a retrospective cohort study
Background Myopia is a growing health issue, expected to affect nearly half of the global population by 2050. Genetic pred...
The Protective Role of Astaxanthin Against Oxidative Stress and Inflammation in Peritoneal Dialysis Rats
Background: Prolonged exposure of peritoneal membrane to dialysate solution is known to cause fibrosis mediated by imbalan...
Nutraceutical benefits and neuro-protective potent of four colored peppers (Capsicum annuum var. grossum)
Background: Four colored peppers (Capsicum annuum var. grossum), orange, purple, yellow and red, are plant foods served as...
Cyclohexylamine, the principal metabolite of cyclamate, contracts the epididymal vas deferens of rats by affecting endogenous catecholamine release via postsynaptic α1Aand presynaptic α2-adrenoceptors in a calcium-dependent manner
Background: Cyclohexylamine (CHA) is a principal metabolite of cyclamate, which was once one of the most prominently consu...
A Staged-OLIF Approach Can Minimize Construct Lengths In Adult Spinal Deformity- A Case Series And Literature Review
Background: Adult Spinal Deformity (ASD) is one of the challenging conditions to treat for spine surgeons. One of the impo...
Neurenteric Cysts: A Neurosurgical Case Series and Treatment Perspectives
Neurenteric cysts (NC) are rare lesions of endodermal origin lined by mucin-secreting cuboidal or columnar epithelium of a...
Russell’s viper envenomation: The Challenge of Diagnosis
Russell’s viper envenomation is rare in Taiwan, and its typical clinical presentations, including consumption coagulopathy...
Metabolomics in cancer detection: A review of techniques, biomarkers, and clinical utility
Cancer poses a significant burden on global public health, contributing to high mortality rates worldwide. Ongoing diagnos...
An Investigation into the Potent Anticancer, Antimicrobial, and Anti-inflammatory Activities of a Punica granatum Nanoemulgel
Purpose: The objective of this study is to formulate a nanoemulgel using Punica granatum (P. granatum) seed oil and study ...
Investigating the association between hyperthyroidism and the risk of herpes zoster in a cohort study in Taiwan
Background: The aim of this cohort study was to investigate the association between hyperthyroidism and the likelihood of ...
Effect of garcinol against arsenic-induced neurobehavioral alterations and liver and kidney dysfunction in albino mice
The extended exposure to inorganic arsenic is commonly linked to brain damage through oxidative and apoptotic processes. T...
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