Allen TA. The role of circulating tumor cells as a liquid biopsy for cancer: advances, biology, technical challenges, and clinical relevance. Cancers (Basel). 2024. https://doi.org/10.3390/cancers16071377.

Article  PubMed  PubMed Central  Google Scholar 

Amatu A, Schirripa M, Tosi F, Lonardi S, Bencardino K, et al. High circulating methylated dna is a negative predictive and prognostic marker in metastatic colorectal cancer patients treated with regorafenib. Front Oncol. 2019;9:622.

Article  PubMed  PubMed Central  Google Scholar 

Anandappa G, Lampis A, Cunningham D, Khan KH, Kouvelakis K, et al. miR-31-3p Expression and benefit from anti-egfr inhibitors in metastatic colorectal cancer patients enrolled in the prospective phase ii prospect-c trial. Clin Cancer Res. 2019;25:3830–8.

Article  CAS  PubMed  Google Scholar 

Andersen LB, Mahler MSK, Andersen RF, Jensen LH, Raunkilde L. The clinical impact of methylated homeobox A9 ctdna in patients with non-resectable biliary tract cancer treated with erlotinib and bevacizumab. Cancers (Basel). 2022;14(19):4598.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aredo JV, Jamali A, Zhu J, Heater N, Wakelee HA, et al. Liquid biopsy approaches for cancer characterization, residual disease detection, and therapy monitoring. Am Soc Clin Oncol Educ Book. 2025;45:e481114.

Article  PubMed  Google Scholar 

Armakolas A, Kotsari M, Koskinas J. Liquid biopsies, novel approaches and future directions. Cancers (Basel). 2023. https://doi.org/10.3390/cancers15051579.

Article  PubMed  PubMed Central  Google Scholar 

Asghar S, Waqar W, Umar M, Manzoor S. Tumor educated platelets, a promising source for early detection of hepatocellular carcinoma: liquid biopsy an alternative approach to tissue biopsy. Clin Res Hepatol Gastroenterol. 2020;44:836–44.

Article  CAS  PubMed  Google Scholar 

Berger MF, Mardis ER. The emerging clinical relevance of genomics in cancer medicine. Nat Rev Clin Oncol. 2018;15:353–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Best MG, Sol N, Kooi I, Tannous J, Westerman BA, et al. RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell. 2015;28:666–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bilegsaikhan E, Liu HN, Shen XZ, Liu TT. Circulating miR-338-5p is a potential diagnostic biomarker in colorectal cancer. J Dig Dis. 2018;19:404–10.

Article  CAS  PubMed  Google Scholar 

Blay JY, Devin Q, Toulmonde M, Dufresne A, Penel N, et al. Twenty-year survival of advanced gastrointestinal stromal tumours treated with imatinib: exploratory long-term follow-up of the BFR14 trial. Ann Oncol. 2025;36:1035–46.

Article  CAS  PubMed  Google Scholar 

Bronkhorst AJ, Holdenrieder S. The changing face of circulating tumor DNA (ctDNA) profiling: factors that shape the landscape of methodologies, technologies, and commercialization. Med Genet. 2023;35:201–35.

CAS  PubMed  PubMed Central  Google Scholar 

Camblor DG, Martínez-Castedo B, Martín-Arana J, Gimeno-Valiente F, García-Micó B, et al. Clinical performance of tumor-informed versus tumor-agnostic ctDNA assays for colorectal cancer recurrence: a systematic review and diagnostic accuracy meta-analysis. Cancer Treat Rev. 2026;142:103066.

Article  CAS  PubMed  Google Scholar 

Casaletto JB, McClatchey AI. Spatial regulation of receptor tyrosine kinases in development and cancer. Nat Rev Cancer. 2012;12:387–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakraborty S, Sharma G, Karmakar S, Banerjee S. Multi-OMICS approaches in cancer biology: new era in cancer therapy. Biochimica et Biophysica Acta (BBA) - Mol Basis Disease. 2024;1870:167120.

Article  CAS  Google Scholar 

Chan HT, Chin YM, Low SK. Circulating tumor dna-based genomic profiling assays in adult solid tumors for precision oncology: recent advancements and future challenges. Cancers (Basel). 2022. https://doi.org/10.3390/cancers14133275.

Article  PubMed  PubMed Central  Google Scholar 

Chan HT, Nagayama S, Otaki M, Chin YM, Fukunaga Y, et al. Tumor-informed or tumor-agnostic circulating tumor DNA as a biomarker for risk of recurrence in resected colorectal cancer patients. Front Oncol. 2022;12:1055968.

Article  CAS  PubMed  Google Scholar 

Chee CE, Krishnamurthi S, Nock CJ, Meropol NJ, Gibbons J, et al. Phase II study of Dasatinib (BMS‐354825) in patients with metastatic adenocarcinoma of the pancreas. Oncologist. 2013;18:1091–2.

Article  PubMed  PubMed Central  Google Scholar 

Cheng H, Zhang L, Cogdell DE, Zheng H, Schetter AJ, et al. Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS ONE. 2011;6:e17745.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, et al. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22:12828.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciardiello D, Martinelli E, Troiani T, Mauri G, Rossini D, et al. Anti-EGFR rechallenge in patients with refractory ctDNA RAS/BRAF wt metastatic colorectal cancer: a nonrandomized controlled trial. JAMA Netw Open. 2024;7:e245635.

Article  PubMed  PubMed Central  Google Scholar 

Cordover E, Minden A. Signaling pathways downstream to receptor tyrosine kinases: targets for cancer treatment. J Cancer Metastasis Treat. 2020. https://doi.org/10.20517/2394-4722.2020.101.

Article  Google Scholar 

Cousin S, Guégan JP, Shitara K, Palmieri LJ, Metges JP, et al. Identification of microenvironment features associated with primary resistance to anti-PD-1/PD-L1 + antiangiogenesis in gastric cancer through spatial transcriptomics and plasma proteomics. Mol Cancer. 2024;23:197.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dasari A, Morris VK, Allegra CJ, Atreya C, Benson AB 3rd, et al. ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper. Nat Rev Clin Oncol. 2020;17:757–70.

Article  PubMed  PubMed Central  Google Scholar 

David P, Mittelstädt A, Kouhestani D, Anthuber A, Kahlert C, et al. Current applications of liquid biopsy in gastrointestinal cancer disease—from early cancer detection to individualized cancer treatment. In Cancers. 2023;15(7):1924.

Article  CAS  PubMed Central  Google Scholar 

Dayyani F, Chao J, Lee FC, Taylor TH, Neumann K, Cho MT. A phase II study of cabozantinib and pembrolizumab in advanced gastric/gastroesophageal adenocarcinomas resistant or refractory to immune checkpoint inhibitors. Oncologist. 2024;29:721-e1088.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng T, Wang F, Zhang L, Ning T, Sun Y, et al. Combinational zimberelimab plus lenvatinib and chemotherapy for alpha-fetoprotein elevated, advanced gastric cancer patients (AFPGC): a phase 1 dose-escalation study. Cancer Immunol Immunother. 2024;73:154.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duffy MJ, Diamandis EP, Crown J. Circulating tumor DNA (ctDNA) as a pan-cancer screening test: is it finally on the horizon? Clinical Chem Laboratory Med (CCLM). 2021;59:1353–61.

Article  CAS  PubMed  Google Scholar 

Engelsen AST, Lotsberg ML, Abou Khouzam R, Thiery JP, Lorens JB, et al. Dissecting the role of AXL in cancer immune escape and resistance to immune checkpoint inhibition. Front Immunol. 2022;13:869676.

Article  CAS  PubMed  PubMed Central