Genetic predisposition to gastric cancer and treatment outcomes in South Asian and Iranian populations: a comprehensive meta-analysis

Ahmed N. 23 years of the discovery of helicobacter pylori: is the debate over? Ann Clin Microbiol Antimicrobials. 2005. https://doi.org/10.1186/1476-0711-4-17.

Article  Google Scholar 

Amjadi MA, Özdemir YC, Ramezani M, et al. Ancient DNA indicates 3,000 years of genetic continuity in the northern iranian plateau, from the copper age to the sassanid empire. Sci Rep. 2025. https://doi.org/10.1038/s41598-025-99743-w.

Article  PubMed  PubMed Central  Google Scholar 

Anderson WF, Rabkin CS, Turner N, et al. The changing face of noncardia gastric cancer incidence among us non-hispanic whites. J Natl Cancer Inst. 2018;110:608–15. https://doi.org/10.1093/jnci/djx262.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arnold M, Ferlay J, van Berge Henegouwen MI, Soerjomataram I. Global burden of oesophageal and gastric cancer by histology and subsite in 2018. Gut. 2020;69:1564–71. https://doi.org/10.1136/gutjnl-2020-321600.

Article  PubMed  Google Scholar 

Arnold M, Karim-Kos HE, Coebergh JW, et al. Recent trends in incidence of five common cancers in 26 european countries since 1988: analysis of the european cancer observatory. Eur J Cancer. 2015;51:1164–87. https://doi.org/10.1016/j.ejca.2013.09.002.

Article  PubMed  Google Scholar 

Arnold M, Park JY, Camargo MC, et al. Is gastric cancer becoming a rare disease? a global assessment of predicted incidence trends to 2035. Gut. 2020;69:823–9. https://doi.org/10.1136/gutjnl-2019-320234.

Article  PubMed  PubMed Central  Google Scholar 

Arnold M, Rutherford MJ, Bardot A, et al. Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (icbp survmark-2): a population-based study. Lancet Oncol. 2019;20:1493–505. https://doi.org/10.1016/s1470-2045(19)30456-5.

Article  PubMed  PubMed Central  Google Scholar 

Baradaran Ghavami S, Chaleshi V, Derakhshani S, et al. Association between tnf-alpha rs1799964 and raf1 rs1051208 microrna binding site snp and gastric cancer susceptibility in an iranian population. Gastroenterol Hepatol Bed Bench. 2017;10:214–9.

PubMed  PubMed Central  Google Scholar 

Bashir H, Majid S, Hamid R, et al. Polymorphism of the xrcc3 gene and risk of gastric cancer in a kashmiri population: a case-control study. Eur J Cancer Prev. 2015;24:167–75. https://doi.org/10.1097/CEJ.0000000000000115.

Article  CAS  PubMed  Google Scholar 

Borenstein M, Hedges LV, Higgins JP, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1:97–111. https://doi.org/10.1002/jrsm.12.

Article  PubMed  Google Scholar 

Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

PubMed  Google Scholar 

Camargo MC, Anderson WF, King JB, et al. Divergent trends for gastric cancer incidence by anatomical subsite in us adults. Gut. 2011;60:1644–9. https://doi.org/10.1136/gut.2010.236737.

Article  PubMed  PubMed Central  Google Scholar 

Cauci S, Buligan C, Rocchi F, et al. Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma. Oncol Lett. 2019. https://doi.org/10.3892/ol.2019.10923.

Article  PubMed  PubMed Central  Google Scholar 

Chand-Bhayal A, Krishnaveni D, Pandu-Ranga-Rao K, et al. Association of interleukin-10 promoter polymorphism (−1082 g/a) and gastric cancer in andhra pradesh population of south india. Iran J Cancer Prev. 2012;5:117–23.

PubMed  PubMed Central  Google Scholar 

Chen S, Chen L, Tan Y, Wang J. Association between rs20417 polymorphism in cyclooxygenase-2 and gastric cancer susceptibility: evidence from15 case-control studies. Medicine (Baltimore). 2019;98:e15468. https://doi.org/10.1097/MD.0000000000015468.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corso G, Berardi A, Marrelli D, et al. Cdh1 c-160a promoter polymorphism and gastric cancer risk. Eur J Cancer Prev. 2009;18:46–9. https://doi.org/10.1097/CEJ.0b013e32830c8d70.

Article  CAS  PubMed  Google Scholar 

Devi SM, Ahmed I, Francalacci P, et al. Ancestral european roots of helicobacter pylori in india. BMC Genomics. 2007;8:184. https://doi.org/10.1186/1471-2164-8-184.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferlay J EM, Lam F, Laversanne M, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I, Bray F. 2024. Global cancer observatory: Cancer today.. https://gco.iarc.who.int/today

Fortunato L, Rushton L. Stomach cancer and occupational exposure to asbestos: a meta-analysis of occupational cohort studies. Br J Cancer. 2015;112:1805–15. https://doi.org/10.1038/bjc.2014.599.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu D, Zheng R, Xin J, et al. Evaluation of gwas-identified genetic variants for gastric cancer survival. EBioMedicine. 2018;33:82–7. https://doi.org/10.1016/j.ebiom.2018.06.028.

Article  PubMed  PubMed Central  Google Scholar 

Guarino-Vignon P, Marchi N, Bendezu-Sarmiento J, et al. Genetic continuity of indo-iranian speakers since the iron age in southern central asia. Sci Rep. 2022;12:733. https://doi.org/10.1038/s41598-021-04144-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hansson L-E, Nyrén O, Hsing AW, et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335:242–9. https://doi.org/10.1056/nejm199607253350404.

Article  CAS  PubMed  Google Scholar 

Heer EV, Harper AS, Sung H, et al. Emerging cancer incidence trends in canada: The growing burden of young adult cancers. Cancer. 2020;126:4553–62. https://doi.org/10.1002/cncr.33050.

Article  PubMed  Google Scholar 

Henderson TO, Oeffinger KC, Whitton J, et al. Secondary gastrointestinal cancer in childhood cancer survivors. Ann Intern Med. 2012. https://doi.org/10.7326/0003-4819-156-11-201206050-00002.

Article  PubMed  PubMed Central  Google Scholar 

Hess T, Maj C, Gehlen J, et al. Dissecting the genetic heterogeneity of gastric cancer. EBioMedicine. 2023. https://doi.org/10.1016/j.ebiom.2023.104616.

Article  PubMed  PubMed Central  Google Scholar 

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60. https://doi.org/10.1136/bmj.327.7414.557.

Article  PubMed  PubMed Central  Google Scholar 

Hong J-B, Zuo W, Wang A-J, Lu N-H. Helicobacter pylori infection synergistic with il-1β gene polymorphisms potentially contributes to the carcinogenesis of gastric cancer. Int J Med Sci. 2016;13:298–303. https://doi.org/10.7150/ijms.14239.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods. 2006;11:193–206. https://doi.org/10.1037/1082-989X.11.2.193.

Article  PubMed  Google Scholar 

Ibrahim M, Gilbert K. Management of gastric cancer in indian population. Transl Gastroenterol Hepatol. 2017;2:64.

Article  PubMed  PubMed Central  Google Scholar 

Katona BW, Rustgi AK. Gastric cancer genomics: Advances and future directions. Cell Mol Gastroenterol Hepatol. 2017;3:211–7. https://doi.org/10.1016/j.jcmgh.2017.01.003.

Article  PubMed  PubMed Central 

Comments (0)

No login
gif