Signaling Effects of alpha-Ketoglutarate Precursor Administration in Rat Soleus Muscle under 7-Day Mechanical Unloading

Shenkman B.S. 2020. How postural muscle senses disuse. Early signs and signals. Int. J. Mol. Sci. 21 (14). https://doi.org/10.3390/ijms21145037

Schiaffino S., Reggiani C. 2011. Fiber types in mammalian skeletal muscles. Physiol. Rev. 91 (4), 1447–1531. https://doi.org/10.1152/physrev.00031.2010

Article  CAS  PubMed  Google Scholar 

Begue G., Raue U., Jemiolo B., Trappe S. 2017. DNA methylation assessment from human slow- and fast-twitch skeletal muscle fibers. J. Appl. Physiol. (1985). 122 (4), 952–967. https://doi.org/10.1152/japplphysiol.00867.2016

Wen Y., Dungan C.M., Mobley C.B., Valentino T., Von Walden F., Murach K.A. 2021. Nucleus type-specific DNA methylomics reveals epigenetic “memory” of prior adaptation in skeletal muscle. Function (Oxf.). 2 (5), https://doi.org/10.1093/function/zqab038

Baar K. 2010. Epigenetic control of skeletal muscle fibre type. Acta Physiol. (Oxf.). 199 (4), 477–487. https://doi.org/10.1111/j.1748-1716.2010.02121

Article  CAS  PubMed  Google Scholar 

Tomiga Y., Ito A., Sudo M., Ando S., Eshima H., Sakai K., Nakashima S., Uehara Y., Tanaka H., Soejima H., Higaki Y. 2019. One week, but not 12 hours, of cast immobilization alters promotor DNA methylation patterns in the nNOS gene in mouse skeletal muscle. J. Physiol. 597 (21), 5145–5159. https://doi.org/10.1113/JP277019

Article  CAS  PubMed  Google Scholar 

Alibegovic A.C., Sonne M.P., Hojbjerre L., Bork-Jensen J., Jacobsen S., Nilsson E., Faerch K., Hiscock N., Mortensen B., Friedrichsen M., Stallknecht B., Dela F., Vaag A. 2010. Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Am. J. Physiol. Endocrinol. Metab. 299 (5), E752–E763. https://doi.org/10.1152/ajpendo.00590.2009

Article  CAS  PubMed  Google Scholar 

Sharlo K.A., Vilchinskaya N.A., Tyganov S.A., Turtikova O.V., Lvova I.D., Sergeeva K.V., Rukavishnikov I.V., Shenkman B.S., Tomilovskaya E.S., Orlov O.I. 2023. 6-Day dry immersion leads to downregulation of slow-fiber type and mitochondria-related genes expression. Am. J. Physiol. Endocrinol. Metab. 325 (6), E734–E743. https://doi.org/10.1152/ajpendo.00284.2023

Article  CAS  PubMed  Google Scholar 

Zhang X., Trevino M.B., Wang M., Gardell S.J., Ayala J.E., Han X., Kelly D.P., Goodpaster B.H., Vega R.B., Coen P.M. 2018. Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J. Gerontol. A. Biol. Sci. Med. Sci. 73 (10), 1313–1322. https://doi.org/10.1093/gerona/gly051

Article  CAS  PubMed  Google Scholar 

Hou P., Kuo C.Y., Cheng C.T., Liou J.P., Ann D.K., Chen Q. 2014. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1alpha by inhibiting prolyl-4-hydroxylase PHD2. PLoS One 9 (11), e113865. https://doi.org/10.1371/journal.pone.0113865

Article  CAS  PubMed  Google Scholar 

Morey-Holton E., Globus R.K., Kaplansky A., Durnova G. 2005. The hindlimb unloading rat model: Literature overview, technique update and comparison with space flight data. Adv. Space. Biol. Med. 10, 7–40. https://doi.org/10.1016/s1569-2574(05)10002-1

Article  PubMed  Google Scholar 

Pfaffl M.W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 (9), e45. https://doi.org/10.1093/nar/29.9.e45

Article  CAS  PubMed  Google Scholar 

Lomonosova Y.N., Turtikova O.V., Shenkman B.S. 2016. Reduced expression of MyHC slow isoform in rat soleus during unloading is accompanied by alterations of endogenous inhibitors of calcineurin/NFAT signaling pathway. J. Muscle Res. Cell Motil. 37 (1–2), 7–16. https://doi.org/10.1007/s10974-015-9428-y

Article  CAS  PubMed  Google Scholar 

Shenkman B.S. 2016. From slow to fast: Hypogravity-induced remodeling of muscle fiber myosin phenotype. Acta Naturae. 8 (4), 47–59.

Article  CAS  PubMed  Google Scholar 

Theilen N.T., Jeremic N., Weber G.J., Tyagi S.C. 2018. Exercise preconditioning diminishes skeletal muscle atrophy after hindlimb suspension in mice. J. Appl. Physiol. 125 (4), 999–1010. https://doi.org/10.1152/japplphysiol.00137.2018

Article  CAS  PubMed  Google Scholar 

Cai X., Yuan Y., Liao Z., Xing K., Zhu C., Xu Y., Yu L., Wang L., Wang S., Zhu X., Gao P., Zhang Y., Jiang Q., Xu P., Shu G. 2018. alpha-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway. FASEB J. 32 (1), 488–499. https://doi.org/10.1096/fj.201700670R

Article  CAS  PubMed  Google Scholar 

Canto C., Auwerx J. 2009. PGC-1alpha, SIRT1 and ADPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol. 20 (2), 98–105. https://doi.org/10.1097/MOL.0b013e328328d0a4

Article  CAS  PubMed  Google Scholar 

Sharlo K.A., Paramonova I.I., Lvova I.D., Vilchinskaya N.A., Bugrova A.E., Shevchenko T.F., Kalamkarov G.R., Shenkman B.S. 2020. NO-dependent mechanisms of myosin heavy chain transcription regulation in rat soleus muscle after 7-days hindlimb unloading. Front. Physiol. 11, 814. https://doi.org/10.3389/fphys.2020.00814

Article  PubMed  Google Scholar 

Su Y., Wang T., Wu N., Li D., Fan X., Xu Z., Mishra S.K., Yang M. 2019. Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating ADPK. Aging (Albany NY). 11 (12), 4183–4197. https://doi.org/10.18632/aging.102045

Article  CAS  PubMed  Google Scholar 

Allen D.L., Sartorius C.A., Sycuro L.K., Leinwand L.A. 2001. Different pathways regulate expression of the skeletal myosin heavy chain genes. J. Biol. Chem. 276 (47), 43 524–43 533. https://doi.org/10.1074/jbc.M108017200

Article  Google Scholar 

Williamson D.L., Butler D.C., Alway S.E. 2009. ADPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism. Am. J. Physiol. Endocrinol. Metab. 297 (2), E304–314. https://doi.org/10.1152/ajpendo.91007.2008

Article  CAS  PubMed  Google Scholar 

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