Giger J.M., Bodell P.W., Zeng M., Baldwin K.M., Haddad F. 2009. Rapid muscle atrophy response to unloading: Pretranslational processes involving MHC and actin. J. Appl. Physiol. (1985). 107 (4), 1204–1212.

Article  Google Scholar 

Vilchinskaya N.A., Mochalova E.P., Nemirovskaya T.L., Mirzoev T.M., Turtikova O.V., Shenkman B.S. 2017. Rapid decline in MyHC I(beta) mRNA expression in rat soleus during hindlimb unloading is associated with AMPK dephosphorylation. J. Physiol. 595 (23), 7123–7134.

Article  CAS  PubMed  Google Scholar 

Paramonova I.I., Vilchinskaya N.A., Shenkman B.S. 2021. HDAC4 is indispensable for reduced slow myosin expression at the early stage of hindlimb unloading in rat soleus muscle. Pharmaceuticals (Basel). 14 (11), 1167.

Article  CAS  PubMed  Google Scholar 

Sharlo K.A., Lvova I.D., Belova S.P., Zaripova K.A., Shenkman B.S., Nemirovskaya T.L. 2022. Metformin attenuates slow-to-fast fiber shift and proteolysis markers increase in rat soleus after 7 days of rat hindlimb unloading. Int. J. Mol. Sci. 24 (1), 503.

Article  PubMed  Google Scholar 

Lomonosova Y.N., Turtikova O.V., Shenkman B.S. 2016. Reduced expression of MyHC slow isoform in rat soleus during unloading is accompanied by alterations of endogenous inhibitors of calcineurin/NFAT signaling pathway. J. Muscle Res. Cell Motil. 37 (1–2), 7–16.

Article  CAS  PubMed  Google Scholar 

Desaphy J.F., Pierno S., Liantonio A., De Luca A., Didonna M.P., Frigeri A., Nicchia G.P., Svelto M., Camerino C., Zallone A., Camerino D.C. 2005. Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile. Neurobiol. Dis. 18 (2), 356–365.

Article  CAS  PubMed  Google Scholar 

Ingalls C.P., Warren G.L., Armstrong R.B. 1999. Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading. J. Appl. Physiol. (1985). 87 (1), 386–390.

Ingalls C.P., Wenke J.C., Armstrong R.B. 2001. Time course changes in [Ca2+]i, force, and protein content in hindlimb-suspended mouse soleus muscles. Aviat. Space Environ. Med. 72 (5), 471–476.

CAS  PubMed  Google Scholar 

Petrov A.M., Kravtsova V.V., Matchkov V.V., Vasiliev A.N., Zefirov A.L., Chibalin A.V., Heiny J.A., Krivoi I.I. 2017. Membrane lipid rafts are disturbed in the response of rat skeletal muscle to short-term disuse. Am. J. Physiol. Cell Physiol. 312 (5), 627–637.

Article  Google Scholar 

Sharlo K.A., Tygonov S.A., Sidorenko D.A., Bokov R.O., Zaripova K.A., Nemirovskaya T.L. 2025. DHPR inhibition prevents strength decline during 3-day functional unloading of the rat soleus muscle. Aviakosmich. ekologich. med. (Rus.). 59 (2), 27–32.

Shen T., Liu Y., Randall W.R., Schneider M.F. 2006. Parallel mechanisms for resting nucleo-cytoplasmic shuttling and activity dependent translocation provide dual control of transcriptional regulators HDAC and NFAT in skeletal muscle fiber type plasticity. J. Muscle Res. Cell Motil. 27, 405–411.

Article  CAS  PubMed  Google Scholar 

Chin E.R., Olson E.N., Richardson J.A., Yang Q., Humphries C., Shelton J.M., Wu H., Zhu W., Bassel-Duby R., Williams R.S. 1998. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev. 12 (16), 2499–2509.

Article  CAS  PubMed  Google Scholar 

Meissner J.D., Umeda P.K., Chang K.C., Gros G., Scheibe R.J. 2007. Activation of the beta myosin heavy chain promoter by MEF-2D, MyoD, p300, and the calcineurin/NFATc1 pathway. J. Cell Physiol. 211 (1), 138–148.

Article  CAS  PubMed  Google Scholar 

Youn H.D., Grozinger C.M., Liu J.O. 2000. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. J. Biol. Chem. 275 (29), 22 563–22 567.

Article  Google Scholar 

Liu Y., Randall W.R., Schneider M.F. 2005. Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle. J. Cell Biol. 168 (6), 887–897.

Article  CAS  PubMed  Google Scholar 

Shenkman B.S. 2016. From slow to fast: Hypogravity-induced remodeling of muscle fiber myosin phenotype. Acta Naturae. 8 (4), 47–59.

Article  CAS  PubMed  Google Scholar 

Moretti I., Ciciliot S., Dyar K.A., Abraham R., Murgia M., Agatea L., Akimoto T., Bicciato S., Forcato M., Pierre P., Uhlenhaut N.H., Rigby P.W., Carvajal J.J., Blaauw B., Calabria E., Schiaffino S. 2016. MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity. Nat. Commun. 7, 12397.

Article  CAS  PubMed  Google Scholar 

Morey-Holton E.R., Globus R.K. 2002. Hindlimb unloading rodent model: Technical aspects. J. Appl. Physiol. (1985). 92 (4), 1367–1377.

Article  Google Scholar 

Novikov V.E., Ilyin E.A. 1981. Age-related reactions of rat bones to their unloading. Aviat. Space Environ. Med. 52 (9), 551–553.

CAS  PubMed  Google Scholar 

Belova S.P., Shenkman B.S., Kostrominova T.Y., Nemirovskaya T.L. 2017. Paradoxical effect of IKKbeta inhibition on the expression of E3 ubiquitin ligases and unloading-induced skeletal muscle atrophy. Physiol. Rep. 5 (16), 13291.

Article  Google Scholar 

Lomonosova Y.N., Shenkman B.S., Nemirovskaya T.L. 2012. Attenuation of unloading-induced rat soleus atrophy with the heat-shock protein inducer 17-(allylamino)-17-demethoxygeldanamycin. FASEB J. 26 (10), 4295–4301.

Article  CAS  PubMed  Google Scholar 

Sharlo K.A., Paramonova I.I., Lvova I.D., Mochalova E.P., Kalashnikov V.E., Vilchinskaya N.A., Tyganov S.A., Konstantinova T.S., Shevchenko T.F., Kalamkarov G.R., Shenkman B.S. 2021. Plantar mechanical stimulation maintains slow myosin expression in disused rat soleus muscle via NO-dependent signaling. Int. J. Mol. Sci. 22 (3), 1372.

Article  CAS  PubMed  Google Scholar 

Sharlo K.A., Paramonova I.I., Turtikova O.V., Tyganov S.A., Shenkman B.S. 2019. Plantar mechanical stimulation prevents calcineurin-NFATc1 inactivation and slow-to-fast fiber type shift in rat soleus muscle under hindlimb unloading. J. Appl. Physiol. (1985). 126 (6), 1769–1781.

Rothermel B.A., McKinsey T.A., Vega R.B., Nicol R.L., Mammen P., Yang J., Antos C.L., Shelton J.M., Bassel-Duby R., Olson E.N., Williams R.S. 2001. Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. USA. 98 (6), 3328–3333.

Article  CAS  PubMed  Google Scholar 

Sharlo K.A., Paramonova I.I., Lvova I.D., Vilchinskaya N.A., Bugrova A.E., Shevchenko T.F., Kalamkarov G.R., Shenkman B.S. 2020. NO-dependent mechanisms of myosin heavy chain transcription regulation in rat soleus muscle after 7-days hindlimb unloading. Front. Physiol. 11, 814.

Article  PubMed  Google Scholar 

Sharlo K.A., Mochalova E.P., Belova S.P., Lvova I.D., Nemirovskaya T.L., Shenkman B.S. 2020. The role of MAP-kinase p38 in the m. soleus slow myosin mRNA transcription regulation during short-term functional unloading. Arch. Biochem. Biophys. 695, 108622.

Article  CAS  PubMed  Google Scholar 

Sharlo K.A., Lvova I.D., Tyganov S.A., Zaripova K.A., Belova S.P., Kostrominova T.Y., Shenkman B.S., Nemirovskaya T.L. 2023. The effect of SERCA activation on functional characteristics and signaling of rat soleus muscle upon 7 days of unloading. Biomolecules. 13 (9), 1354.

Article  CAS  PubMed  Google Scholar 

Paramonova I.I., Sharlo K.A., Vilchinskaya N.A., Shenkman B.S. 2020. The time course of muscle nuclear content of transcription factors regulating the MyHC I(β) expression in the rat soleus muscle under gravitational unloading. Biochem. (Moscow) Suppl. Ser. A, Membr. Cell Biol. 14 (3), 242–248.

Google Scholar 

Meissner J.D., Freund R., Krone D., Umeda P.K., Chang K.C., Gros G., Scheibe R.J. 2011. Extracellular signal-regulated kinase 1/2-mediated phosphorylation of p300 enhances myosin heavy chain I/beta gene expression via acetylation of nuclear factor of activated T cells c1. Nucleic Acids Res. 39 (14), 5907–5925.

Article  CAS  PubMed  Google Scholar 

Mochalova E.P., Belova S.P., Mirzoev T.M., Shenkman B.S., Nemirovskaya T.L. 2019. Atrogin-1/MAFbx mRNA expression is regulated by histone deacetylase 1 in rat soleus muscle under hindlimb unloading. Sci. Rep. 9 (1), 10263.

Article  PubMed  Google Scholar 

Mukhina A.M., Altaeva E.G., Nemirovskaya T.L., Shenkman B.S. 2008. The role of L-type calcium channels in the accumulation of Ca2+ in soleus muscle fibers in the rat and changes in the ratio of myosin and serca isoforms in conditions of gravitational unloading. Neurosci. Behav. Physiol. 38 (2), 181–188.

Article  CAS  PubMed  Google Scholar