The Potential for Using the Mechanism of Hypoxic Adaptation in Lower Eukaryotes

Margulis L., Sagan D. 1986. Microcosmos: Four billion years of microbial evolution. In: Chapter 6, The Oxygen Holocaust. California: University of California Press, p. 99.

Zorov D.B., Juhaszova M., Sollott S.J. 2014. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol. Rev. 94 (3), 909–950.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zorov D.B., Bannikova S.Y., Belousov V.V., Vyssokikh M.Y., Zorova L.D., Isaev N.K., Krasnikov B.F., Plotnikov E.Y. 2015. Reactive oxygen and nitrogen species: Friends or foes? Biochemistry (Moscow). 70 (2), 215–221.

Article  Google Scholar 

Zorov D.B., Isaev N.K., Plotnikov E.Y., Zorova L.D., Stelmashook E.V., Vasileva A.K., Arkhangelskaya A.A., Khrjapenkova T.G. 2007. The mitochondrion as Janus bifrons. Biochemistry (Moscow). 72 (10), 1115–1126.

Article  CAS  PubMed  Google Scholar 

Plotnikov E.Y., Vasileva A.K., Arkhangelskaya A.A., Pevzner I.B., Skulachev V.P., Zorov D.B. 2008. Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: Protective effects of SkQ1, lithium ions and insulin. FEBS Lett. 582 (20), 3117–3124.

Article  CAS  PubMed  Google Scholar 

Ito K., Nioka S., Chance B. 1990. Oxygen dependence of energy state and cardiac work in the perfused rat heart. Adv. Exp. Med. Biol. 277, 449–457.

Article  CAS  PubMed  Google Scholar 

Chandel N.S., Budinger G.R., Choe S.H., Schumacker P.T. 1997. Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J. Biol. Chem. 272 (30), 18 808–18 816.

Article  Google Scholar 

Korshunov S.S., Skulachev V.P., Starkov A.A. 1997. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416 (1), 15–18.

Article  CAS  PubMed  Google Scholar 

Starkov A.A., Fiskum G. 2003. Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J. Neurochem. 86 (5), 1101–1107.

Article  CAS  PubMed  Google Scholar 

Krogh A. 1919. The supply of oxygen to the tissues and the regulation of capillary circulation. J. Physiol. 52, 457–474.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chance B., Williams G.R. 1955. Respiratory enzymes in oxidative phosphorylation. IV. The respiratory chain. J. Biol. Chem. 217 (1), 429–438.

Article  CAS  PubMed  Google Scholar 

Chance B., Cohen P., Jobsis F., Schoener B. 1962. Intracellular oxidation-reduction states in vivo. Science. 137 (3529), 499–508.

Article  CAS  PubMed  Google Scholar 

Degn H., Wohlrab H. 1971. Measurement of steady-state values of respiration rate and oxidation levels of respiratory pigments at low oxygen tensions. A new technique. Biochim. Biophys. Acta. 245, 347–355.

Article  CAS  PubMed  Google Scholar 

Rosenthal M., Lamanna J.C., Jöbsis F.F., Levasseur J.E., Kontos H.A., Patterson J.L. 1976. Effects of respiratory gases on cytochrome A in intact cerebral cortex: Is there critical Po2? Brain Res. 108 (1), 143–154.

Article  CAS  PubMed  Google Scholar 

Jöbsis F.F., Keizer J.H., LaManna J.C., Rosenthal M. 1977. Reflectance spectrophotometry of cytochrome aa3 in vivo. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 43 (5), 858–872.

PubMed  Google Scholar 

Bashford C.L., Barlow C.H., Chance B., Haselgrove J., Sorge J. 1982. Optical measurements of oxygen delivery and consumption in gerbil cerebral cortex. Am. J. Physiol. 242 (5), C265–271.

Article  CAS  PubMed  Google Scholar 

Zorov D.B., Krasnikov B.F., Kuzminova A.E., Vysokikh M.Yu., Zorova L.D. 1997. Mitochondria revisited. Alternative functions of mitochondria. Biosci. Rep. 17 (6), 507–520.

Article  CAS  PubMed  Google Scholar 

Burmeste T. 2002. Origin and evolution of arthropod hemocyanins and related proteins. J. Comp. Physiol. B. 172, 95–107.

Article  Google Scholar 

Kurtz D.M. Jr 1999. Oxygen-carrying proteins: Three solutions to a common problem. Essays Biochem. 34, 85–100.

Article  CAS  PubMed  Google Scholar 

Burmester T., Hankeln T. 2014. Function and evolution of vertebrate globins. Acta Physiol. (Oxford). 211 (3), 501–514.

Article  CAS  Google Scholar 

Van Hellemond J.J., Klockiewicz M., Gaasenbeek C.P., Roos M.H., Tielens A.G. 1995. Rhodoquinone and complex II of the electron transport chain in anaerobically functioning eukaryotes. J. Biol. Chem. 270 (52), 31065–31070.

Article  CAS  PubMed  Google Scholar 

Kita K., Hirawake H., Miyadera H., Amino H., Takeo S. 2002. Role of complex II in anaerobic respiration of the parasite mitochondria from Ascaris suum and Plasmodium falciparum. Biochim. Biophys. Acta. 553 (1–2), 123–139.

Article  Google Scholar 

Sakai C., Tomitsuka E., Esumi H., Harada S., Kita K. 2012. Mitochondrial fumarate reductase as a target of chemotherapy: From parasites to cancer cells. Biochim. Biophys. Acta. 1820 (5), 643–651.

Valeros J., Jerome M., Tseyang T., Vo P., Do T., et al. 2025. Rhodoquinone carries electrons in the mammalian electron transport chain. Cell. 188, 1084–1099.

Article  CAS  PubMed  Google Scholar 

Ryan D.G., Murphy M.P., Frezza C., Prag H.A., Chouchani E.T., O’Neill L.A., Mills E.L. 2018. Coupling Krebs cycle metabolites to signaling in immunity and cancer. Nat. Metab. 1, 16–33.

Article  Google Scholar 

Bisbach C.M., Hass D.T., Robbings B.M., Rountree A.M., Sadilek M., Sweet I.R., Hurley J.B. 2020. Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium. Cell Rep. 31, 107606.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reddy A., Bozi L.H.M., Yaghi O.K., Mills E.L., Xiao H., Nicholson H.E., Paschini M., Paulo J.A., Garrity R., Laznik-Bogoslavski D., et al. 2020. pH-Gated succinate secretion regulates muscle remodeling in response to exercise. Cell. 183, 62–75.e17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toma I., Kang J.J., Sipos A., Vargas S., Bansal E., Hanner, F., Meer E., Peti-Peterdi J. 2008. Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney. J. Clin. Investig. 118, 2526–2534.

CAS  PubMed  PubMed Central  Google Scholar 

Wu K.K. 2023. Extracellular succinate: A physiological messenger and a pathological trigger. Int. J. Mol. Sci. 24, 11165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selak M.A., Armour S.M., MacKenzie E.D., Boulahbel H., Watson D.G., Mansfield K.D., Pan Y., Simon M.C., Thompson C.B., Gottlieb E. 2005. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 7, 77–85.

Article  CAS  PubMed  Google Scholar 

Michelucci A., Cordes T., Ghelfi J., Pailot A., Reiling N., Goldmann O., Binz T., Wegner A., Tallam A., Rausell A. et al. 2013. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc. Natl. Acad. Sci. USA. 110, 7820–7825.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jha A.K., Huang S.C.-C., Sergushichev A., Lampropoulou V., Ivanova Y., et al. 2015. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity. 42, 419–430.

Article  CAS  PubMed  Google Scholar 

Li Z., Zheng W., Kong W., Zeng T. 2023. T. Itaconate: A potent macrophage immunomodulator. Inflammation. 46, 1177–1191.

Article  CAS  PubMed 

Comments (0)

No login
gif