Briones-Aranda A, Flores-Durán D, Romero-Nava R, Corzo-Gómez JC, Cruz-Trujillo R, Toalá-Sepúlveda F, et al. Role of 5-HT1A and 5-HT7 receptors in memory regulation and the importance of their coexpression: a systematic review. Biomolecules. 2025;15:762.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, Wang N, Zhang L, Zhuang Y, Xin Q, Gu X, et al. Serotonin (5-Hydroxytryptamine): metabolism, signaling, biological functions, diseases, and emerging therapeutic opportunities. MedComm. 2020;2025(6):e70383.
Liu S, He M, Sun H, Wu Y, Jin W. 5-Hydroxytryptamine G-protein-coupled receptor family genes: key players in cancer prognosis, immune regulation, and therapeutic response. Genes (Basel). 2024;15:1541-62.
Wang X, Shi M, Tian J, Yu W. Cancer and neurotransmitter receptors. Chin Med J. 2025;138(13):1540–58.
Article CAS PubMed PubMed Central Google Scholar
Meleiro M, Henrique R. Epigenetic alterations in glioblastoma multiforme as novel therapeutic targets: a scoping review. Int J Mol Sci. 2025;26.
Singh S, Dey D, Barik D, Mohapatra I, Kim S, Sharma M, et al. Glioblastoma at the crossroads: current understanding and future therapeutic horizons. Signal Transduct Target Ther. 2025;10:213.
Article PubMed PubMed Central Google Scholar
Liu Y, Zhou F, Ali H, Lathia JD, Chen P. Immunotherapy for glioblastoma: current state, challenges, and future perspectives. Cell Mol Immunol. 2024;21:1354–75.
Article CAS PubMed PubMed Central Google Scholar
Stockham AL, Tievsky AL, Koyfman SA, Reddy CA, Suh JH, Vogelbaum MA, et al. Conventional MRI does not reliably distinguish radiation necrosis from tumor recurrence after stereotactic radiosurgery. J Neurooncol. 2012;109:149–58.
Lawrence LSP, Chan RW, Singnurkar A, Detsky J, Heyn C, Maralani PJ, et al. Applications of advanced imaging for radiotherapy planning and response assessment in the central nervous system. Tomography. 2025;11:68.
Article PubMed PubMed Central Google Scholar
Binneboese A, Covington MF, Horn KP, Archibald ZG, Boucher KM, Morton KA, et al. Correlation between FDG-PET uptake and survival in patients with primary brain tumors. Am J Nucl Med Mol Imaging. 2021;11:196–206.
CAS PubMed PubMed Central Google Scholar
Cao X, Tan D, Liu Z, Liao M, Kan Y, Yao R, et al. Differentiating solitary brain metastases from glioblastoma by radiomics features derived from MRI and 18F-FDG-PET and the combined application of multiple models. Sci Rep. 2022;12:5722.
Article CAS PubMed PubMed Central Google Scholar
Kawasaki T, Miwa K, Shinoda J, Asano Y, Takei H, Ikegame Y, et al. Dissociation between 11 C-methionine-positron emission tomography and gadolinium-enhanced magnetic resonance imaging in longitudinal features of glioblastoma after postoperative radiotherapy. World Neurosurg. 2019;125:93–100.
Palanichamy K, Chakravarti A. Diagnostic and prognostic significance of methionine uptake and methionine positron emission tomography imaging in gliomas. Front Oncol. 2017;7:257.
Article PubMed PubMed Central Google Scholar
Pessina F, Navarria P, Clerici E, Bellu L, Franzini A, Milani D et al. Role of 11 C Methionine Positron Emission Tomography (11CMETPET) for surgery and radiation therapy planning in newly diagnosed glioblastoma patients enrolled into a phase II clinical study. J Clin Med. 2021;10:2313-26.
Sipos D, Debreczeni-Máté Z, Ritter Z, Freihat O, Simon M, Kovács Á. Complex diagnostic challenges in glioblastoma: the role of (18)F-FDOPA PET imaging. Pharmaceuticals (Basel). 2024;17:1215-31.
Sipos D, László Z, Tóth Z, Kovács P, Tollár J, Gulybán A, et al. Additional value of 18F-FDOPA amino acid analog radiotracer to irradiation planning process of patients with glioblastoma multiforme. Front Oncol. 2021;11:699360.
Article CAS PubMed PubMed Central Google Scholar
Ferjančič P, Ebert MA, Francis R, Nowak AK, Jeraj R. Repeatability of Quantitative 18F-FET PET in Glioblastoma. Biomed Phys Eng Express. 2021;7:035020.
Nedergaard MK, Michaelsen SR, Urup T, Broholm H, El Ali H, Poulsen HS, et al. 18F-FET microPET and microMRI for anti-VEGF and anti-PlGF response assessment in an orthotopic murine model of human glioblastoma. PLoS ONE. 2015;10:e0115315.
Article PubMed PubMed Central Google Scholar
Dagher SA, Johnson JM, Mohamed RMM, Ansari S, Mawlawi O, Liu HL, et al. Study of 18 F-fluciclovine PET for serial assessment of glioblastoma tumor volumes during surgery and radiotherapy. J Neurooncol. 2025;175:549–60.
Article CAS PubMed PubMed Central Google Scholar
Bolcaen J, Kleynhans J, Nair S, Verhoeven J, Goethals I, Sathekge M, et al. A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma. Theranostics. 2021;11:7911–47.
Article CAS PubMed PubMed Central Google Scholar
Alexiou GA, Tsiouris S, Kyritsis AP, Fotakopoulos G, Goussia A, Voulgaris S, et al. The value of 99mTc-tetrofosmin brain SPECT in predicting survival in patients with glioblastoma multiforme. J Nucl Med. 2010;51:1923–6.
Osawa S, Tosaka M, Horiguchi K, Tokue A, Higuchi T, Tsushima Y, et al. Usefulness of dual isotope (123)I-IMP and (201)Tl SPECT for the diagnosis of primary central nervous system lymphoma and glioblastoma. Int J Clin Oncol. 2022;27:1264–72.
Article CAS PubMed Google Scholar
Hulshof MC, Rehmann CJ, Booij J, van Royen EA, Bosch DA, González González D. Lack of perfusion enhancement after administration of nicotinamide and carbogen in patients with glioblastoma: a 99mTc-HMPAO SPECT study. Radiother Oncol. 1998;48:135–42.
Article CAS PubMed Google Scholar
Nagamachi S, Jinnouchi S, Nabeshima K, Nishii R, Flores L 2nd, Kodama T, et al. The correlation between 99mTc-MIBI uptake and MIB-1 as a nuclear proliferation marker in glioma–a comparative study with 201Tl. Neuroradiology. 2001;43:1023–30.
Article CAS PubMed Google Scholar
Saednia S, Emami S, Molavipordanjani S, Abedi SM, Amiri FT, Hosseinimehr SJ. Synthesis and biological evaluation of (99m)Tc-labeled phenylpiperazine derivatives as selective serotonin-7 receptor ligands for brain tumor imaging. Mol Pharm. 2021;18:2360–74.
Article CAS PubMed Google Scholar
Karimi M, Mardanshahi A, Irannejad H, Mohammad Abedi S, Molavipordanjani S. Synthesis and evaluation of (99m)Tc-labeled 1-(2-Pyridyl)piperazine derivatives as radioligands for 5HT(7) receptors. Bioorg Chem. 2023;135:106486.
Article CAS PubMed Google Scholar
Mardanshahi A, Vaseghi S, Hosseinimehr SJ, Abedi SM, Molavipordanjani S. 99mTc(CO)3-labeled 1-(2-Pyridyl)piperazine derivatives as radioligands for 5-HT7 receptors. Ann Nucl Med. 2024;38:139–53.
Article CAS PubMed Google Scholar
Molavipordanjani S. 99mTc(CO)3-Labeled 1-(3-Nitropyridin-2-yl) Piperazine as potential radioligand for 5-HT7 receptors. J Mazandaran Univ Med Sci. 2024;34:14–25.
Lacivita E, Niso M, Hansen HD, Di Pilato P, Herth MM, Lehel S, et al. Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor. Bioorg Med Chem. 2014;22:1736–50.
Article CAS PubMed Google Scholar
Narayanaswami V, Tong J, Fiorino F, Severino B, Sparaco R, Magli E, et al. Synthesis, in vitro and in vivo evaluation of 11 C-O-methylated arylpiperazines as potential serotonin 1A (5-HT1A) receptor antagonist radiotracers. EJNMMI Radiopharm Chem. 2020;5:13.
Article PubMed PubMed Central Google Scholar
Hazari PP, Pandey A, Chaturvedi S, Mishra AK. New trends and current status of positron-emission tomography and single-photon-emission computerized tomography radioligands for neuronal serotonin receptors and serotonin transporter. Bioconjug Chem. 2017;28:2647–72.
Article CAS PubMed Google Scholar
Zenati K, Malek Saied N, Asmi A, Saidi M. Synthesis and biological evaluation of 99mTc labeled aryl piperazine derivatives as cerebral radiotracers. J Radioanal Nucl Chem. 2017;312:67–74.
Shimoda Y, Yui J, Xie L, Fujinaga M, Yamasaki T, Ogawa M, et al. Synthesis and evaluation of 1-[2-(4-[11 C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain. Bioorg Med Chem. 2013;21:5316–22.
Article CAS PubMed Google Scholar
Alberto R, Ortner K, Wheatley N, Schibli R, Schubiger AP. Synthesis and properties of boranocarbonate: a convenient in situ CO source for the aqueous preparation of [(99m)Tc(OH(2))3(CO)3]+. J Am Chem Soc. 2001;123:3135–6.
Comments (0)