Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance

Burke A, Mont E, Kutys R, Virmani R (2005) Left ventricular noncompaction: a pathological study of 14 cases. Hum Pathol 36(4):403–411. https://doi.org/10.1016/j.humpath.2005.02.004

Article  PubMed  Google Scholar 

Pittorru R, De Lazzari M, Migliore F, Frasson E, Zorzi A, Cipriani A, Brunetti G, De Conti G, Motta R, Perazzolo Marra M, Corrado D (2024) Left ventricular non-compaction: evolving concepts. J Clin Med 13(19):5674

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaski JP, Arbelo E (2024) The 2023 ESC guidelines for the management of cardiomyopathies: the 10 commandments. Eur Heart J 45(13):1101. https://doi.org/10.1093/eurheartj/ehad858

Article  PubMed  Google Scholar 

Petersen SE, Selvanayagam JB, Francis JM, Myerson SG, Neubauer S (2014) Differentiation of athlete’s heart from pathological forms of cardiac hypertrophy by means of geometric indices derived from cardiovascular magnetic resonance. JACC Cardiovasc Imaging. https://doi.org/10.1081/jcmr-200060631

Article  PubMed  Google Scholar 

Ramchand J, Podugu P, Obuchowski N, Harb SC, Chetrit M, Milinovich A, Griffin B, Burrell LM, Wilson Tang WH, Kwon DH, Flamm SD (2021) Novel approach to risk stratification in left ventricular non-compaction using a combined cardiac imaging and plasma biomarker approach. J Am Heart Assoc 10(8):e019209. https://doi.org/10.1161/JAHA.120.019209

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petersen SE, Jensen B, Aung N, Friedrich MG, McMahon CJ, Mohiddin SA, Pignatelli RH, Ricci F, Anderson RH, Bluemke DA (2023) Excessive trabeculation of the left ventricle: JACC: cardiovascular imaging expert panel paper. JACC Cardiovasc Imaging 16(3):408–425. https://doi.org/10.1016/j.jcmg.2022.12.026

Article  PubMed  PubMed Central  Google Scholar 

Filho DCS, do Rêgo Aquino PL, de Souza Silva G, Fabro CB (2021) Left ventricular noncompaction: new insights into a poorly understood disease. Curr Cardiol Rev 17(2):209–216. https://doi.org/10.2174/1573403X16666200716151015

Article  PubMed  PubMed Central  Google Scholar 

Casanova JD, Carrillo JG, Jiménez JM, Muñoz JC, Esparza CM, Alvárez MS, Escribá R, Milla EB, de la Pompa JL, Raya Á, Gimeno JR, Molina MS, García GB (2020) Trabeculated myocardium in hypertrophic cardiomyopathy: clinical consequences. J Clin Med 9(10):3171. https://doi.org/10.3390/jcm9103171

Article  PubMed  PubMed Central  Google Scholar 

Sigvardsen PE, Fuchs A, Kühl JT, Afzal S, Køber L, Nordestgaard BG, Kofoed KF (2021) Left ventricular trabeculation and major adverse cardiovascular events: the Copenhagen General Population Study. Eur Heart J Cardiovasc Imaging 22(1):67–74. https://doi.org/10.1093/ehjci/jeaa110

Article  PubMed  Google Scholar 

Arbustini E, Favalli V, Narula N, Serio A, Grasso M (2016) Left ventricular noncompaction: a distinct genetic cardiomyopathy? J Am Coll Cardiol 68(9):949–66. https://doi.org/10.1016/j.jacc.2016.08.025

Article  PubMed  Google Scholar 

Mazzarotto F, Hawley MH, Beltrami M, Beekman L, de Marvao A, McGurk KA, Statton B, Boschi B, Girolami F, Roberts AM, Lodder EM, Allouba M, Romeih S, Aguib Y, Baksi AJ, Pantazis A, Prasad SK, Cerbai E, Yacoub MH, O’Regan DP, Cook SA, Ware JS, Funke B, Olivotto I, Bezzina CR, Barton PJR, Walsh R (2021) Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies. Genet Med 23(5):856–864. https://doi.org/10.1038/s41436-020-01049-x. Epub 2021 Jan 26

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rojanasopondist P, Nesheiwat L, Piombo S, Porter GA Jr, Ren M, Phoon CKL (2022) Genetic basis of left ventricular noncompaction. Circ Genom Precis Med 15(3):e003517. https://doi.org/10.1161/CIRCGEN.121.003517

Article  CAS  PubMed  Google Scholar 

Hoedemaekers YM, Caliskan K, Michels M, Frohn-Mulder I, van der Smagt JJ, Phefferkorn JE, Wessels MW, ten Cate FJ, Sijbrands EJ, Dooijes D, Majoor-Krakauer DF (2010) The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy. Circ Cardiovasc Genet 3(3):232–239. https://doi.org/10.1161/CIRCGENETICS.109.903898. Epub 2010 Jun 8

Article  PubMed  Google Scholar 

Femia G, Semsarian C, Ross SB, Celermajer D, Puranik R (2020) Left ventricular non-compaction: review of the current diagnostic challenges and consequences in athletes. Medicina (Kaunas) 56(12):697. https://doi.org/10.3390/medicina56120697

Article  PubMed  PubMed Central  Google Scholar 

Di Lisi D, Macaione F, Damiani F, Ganci L, Mirabella M, Madaudo C, Galassi AR, Novo G (2024) What happened to the left ventricular non-compaction cardiomyopathy? To be or not to be: this is the question. Curr Probl Cardiol 49(11):102787. https://doi.org/10.1016/j.cpcardiol.2024.102787

Article  PubMed  Google Scholar 

Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R (1990) Isolated noncompaction of left ventricular myocardium. A study of eight cases Circulation 82(2):507–513. https://doi.org/10.1161/01.cir.82.2.507

Article  CAS  PubMed  Google Scholar 

Jenni R, Oechslin E, Schneider J, Attenhofer Jost C, Kaufmann PA (2001) Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy. Heart 86(6):666–671. https://doi.org/10.1136/heart.86.6.666

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bennett CE, Freudenberger R (2016) The current approach to diagnosis and management of left ventricular noncompaction cardiomyopathy: review of the literature. Cardiol Res Pract 2016:5172308. https://doi.org/10.1155/2016/5172308

Article  PubMed  PubMed Central  Google Scholar 

Floria M, Tinica G, Grecu M (2014) Left ventricular non-compaction -challenges and controversies. Maedica (Bucur) 9(3):282–288

PubMed  PubMed Central  Google Scholar 

Gebhard C, Stähli BE, Greutmann M, Biaggi P, Jenni R, Tanner FC (2012) Reduced left ventricular compacta thickness: a novel echocardiographic criterion for non-compaction cardiomyopathy. J Am Soc Echocardiogr 25(10):1050–1057. https://doi.org/10.1016/j.echo.2012.07.003. Epub 2012 Aug 9

Article  PubMed  Google Scholar 

Kohli SK, Pantazis AA, Shah JS, Adeyemi B, Jackson G, McKenna WJ, Sharma S, Elliott PM (2008) Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria? Eur Heart J 29(1):89–95. https://doi.org/10.1093/eurheartj/ehm481. Epub 2007 Nov 9

Article  PubMed  Google Scholar 

Diwadkar S, Nallamshetty L, Rojas C, Athienitis A, Declue C, Cox C, Patel A, Chae SH (2017) Echocardiography fails to detect left ventricular noncompaction in a cohort of patients with noncompaction on cardiac magnetic resonance imaging. Clin Cardiol 40(6):364–369. https://doi.org/10.1002/clc.22669. Epub 2017 Mar 7

Article  PubMed  PubMed Central  Google Scholar 

Donghi V et al (2020) Left-ventricular non-compaction-comparison between different techniques of quantification of trabeculations: Should the diagnostic thresholds be modified? Arch Cardiovasc Dis 113(5):321–331. https://doi.org/10.1016/j.acvd.2020.01.004

Article  PubMed  Google Scholar 

Zuccarino F, Vollmer I, Sanchez G, Navallas M, Pugliese F (2015) Left ventricular non-compaction: imaging findings and diagnostic criteria. Cardiopulm Imaging Rev 204:519–530

Google Scholar 

Adabifirouzjaei F, Igata S, DeMaria AN (2021) Hypertrabeculation; a phenotype with heterogeneous etiology. Prog Cardiovasc Dis 68:60–69. https://doi.org/10.1016/j.pcad.2021.07.007

Article  PubMed  Google Scholar 

Dorobantu DM, Radulescu CR, Riding N, McClean G, de la Garza MS, Abuli-Lluch M, Duarte N, Adamuz MC, Ryding D, Perry D, McNally S, Stuart AG, Sitges M, Oxborough DL, Wilson M, Williams CA, Pieles GE (2023) The use of 2-D speckle tracking echocardiography in assessing adolescent athletes with left ventricular hypertrabeculation meeting the criteria for left ventricular non-compaction cardiomyopathy. Int J Cardiol 371:500–507. https://doi.org/10.1016/j.ijcard.2022.09.076

Article  PubMed  Google Scholar 

Nemes A, Caliskan K, Soliman OI, McGhie JS, Geleijnse ML, ten Cate FJ (2009) Diagnosis of biventricular non-compaction cardiomyopathy by real-time three-dimensional echocardiography. Eur J Echocardiogr 10(2):356–357. https://doi.org/10.1093/ejechocard/jep008. Epub 2009 Feb 12

Article  PubMed  Google Scholar 

Stacey RB, Andersen MM, St Clair M, Hundley WG, Thohan V (2013) Comparison of systolic and diastolic criteria for isolated LV noncompaction in CMR. JACC Cardiovasc Imaging 6(9):931–940. https://doi.org/10.1016/j.jcmg.2013.01.014. Epub 2013 Jun 13.

Article  PubMed 

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