Feng, F. and Zhao, Y., Hepatocellular carcinoma: Prevention, diagnosis, and treatment, Med. Princ. Pract., 2024, vol. 33, no. 5, pp. 414–423. https://doi.org/10.1159/000539349
Farooq, S., Faiz, S., Wahab, A., and Choudhary, M.I., Determination of hepatitis C virus subtype prevalent in Sindh, Pakistan: a phylogenetic analysis, Sci. Rep., 2024, vol. 14, no. 1, p. 11159. https://doi.org/10.1038/s41598-024-59342-7
Article CAS PubMed Google Scholar
Alawyia, B. and Constantinou, C., Hepatocellular carcinoma: A narrative review on current knowledge and future prospects, Curr. Treat. Options Oncol., 2023, vol. 24, no. 7, pp. 711–724. https://doi.org/10.1007/s11864-023-01098-9
Yang, M., Wang, D., Wang, X., Mei, J., and Gong, Q., Role of folate in liver diseases, Nutrients, 2024, vol. 16, no. 12, p. 1872. https://doi.org/10.3390/nu16121872
Article CAS PubMed Google Scholar
Castaño-Moreno, E., Castillo, V., Peñailillo, R., Llanos, M.N., Valenzuela, R., and Ronco, A.M., Fatty acid and lipid metabolism in liver of pregnant mice and their offspring is influenced by unbalanced folates/vitamin B12 diets, Prostaglandins, Leukotrienes Essent. Fatty Acids, 2020, vol. 154, p. 102057. https://doi.org/10.1016/j.plefa.2020.102057
Kang, S.S., Wong, P.W., and Norusis, M., Homocysteinemia due to folate deficiency, Metabolism, 1987, vol. 36, no. 5, pp. 458–462. https://doi.org/10.1016/0026-0495(87)90043-6
Article CAS PubMed Google Scholar
Bukharaeva, E., Shakirzyanova, A., Khuzakhmetova, V., Sitdikova, G., and Giniatullin, R., Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: Potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia, Front. Cell. Neurosci., 2015, vol. 9, p. 391. https://doi.org/10.3389/fncel.2015.00391
Article CAS PubMed Google Scholar
Xie, D., Yuan, Y., Guo, J., Yang, S., Xu, X., Wang, Q., Li, Y., Qin, X., Tang, G., Huo, Y., Deng, G., Wu, S., Wang, B., Zhang, Q., Wang, X., Fang, P., Wang, H., Xu, X., and Hou, F., Hyperhomocysteinemia predicts renal function decline: A prospective study in hypertensive adults, Sci. Rep., 2015, vol. 5, p. 16268. https://doi.org/10.1038/srep16268
Article CAS PubMed Google Scholar
Carboni, L., Active folate versus folic acid: the role of 5-MTHF (methylfolate) in human health, Integr. Med. (Encinitas), 2022, vol. 21, no. 3, p. 36.
Coppedè, F., Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation, Cancer Lett., 2014, vol. 342, no. 2, pp. 238–247. https://doi.org/10.1016/j.canlet.2011.12.030
Article CAS PubMed Google Scholar
Ren, Q., Zhang, G., Yan, R., Zhou, D., Huang, L., Zhang, Q., Li, W., Huang, G., Li, Z., and Yan, J., SAM/SAH mediates parental folate deficiency-induced neural cell apoptosis in neonatal rat offspring: The expression of Bcl-2, Bax, and Caspase-3, Int. J. Mol. Sci., 2023, vol. 24, no. 19, p. 14508. https://doi.org/10.3390/ijms241914508
Article CAS PubMed Google Scholar
Cai, Y., Liu, B., Zhang, Y., and Zhou, Y., MTHFR gene polymorphisms in diabetes mellitus, Clin. Chim. Acta, 2024, vol. 561, p. 119825. https://doi.org/10.1016/j.cca.2024.119825
Article CAS PubMed Google Scholar
Wu, D.F., Yin, R.X., and Deng, J.L., Homocysteine, hyperhomocysteinemia, and H-type hypertension, Eur. J. Prev. Cardiol., 2024. vol. 31, no. 9, pp. 1092–1103. https://doi.org/10.1093/eurjpc/zwae022
Luo, J., Chen, X., Guo, H., Zhao, P., Yao, H., Feng, L., and Yang, L., Novel MTR compound-heterozygous mutations in a Chinese girl with HHcy due to methionine synthase deficiency, cblG: A case report, Egypt. J. Med. Hum. Genet., 2024, vol. 25, no. 1, p. 1. https://doi.org/10.1186/s43042-023-00469-z
Gottshall, S.L., Tekin, S., and Hansen, P.J., Laboratory Procedures, Gainesville, FL: Univ. Florida, 2008.
Livak, K.J. and Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method, Methods, 2001, vol. 25, no. 4, pp. 402–408. https://doi.org/10.1006/meth.2001.1262
Article CAS PubMed Google Scholar
Dallakyan, S. and Olson, A.J., Small-molecule library screening by docking with PyRx, in Chemical Biology, Methods in Molecular Biology, vol. 1263, New York: Humana, 2015, pp. 243–250. https://doi.org/10.1007/978-1-4939-2269-7_19
Pettersen, E.F., Goddard, T.D., Huang, C.C., Couch, G.S., Greenblatt, D.M., Meng, E.C., and Ferrin, T.E., UCSF Chimera–a visualization system for exploratory research and analysis, J. Comput. Chem., 2004, vol. 25, no. 13, pp. 1605–1612. https://doi.org/10.1002/jcc.20084
Article CAS PubMed Google Scholar
Margetts, J., Ogle, L.F., Chan, S.L., Chan, A.W.H., Chan, K.C.A., Jamieson, D., Willoughby, C.E., Mann, D.A., Wilson, C.L., Manas, D.M., Yeo, W., and Reeves, H.L., Neutrophils: Driving progression and poor prognosis in hepatocellular carcinoma?, Br. J. Cancer, 2018, vol. 118, no. 2, pp. 248–257. https://doi.org/10.1038/bjc.2017.386
Article CAS PubMed Google Scholar
Kubo, Y., Shoji, K., Tajima, A., Horiguchi, S., Fukuoka, H., Nishikawa, M., Kagawa, Y., and Kawabata, T., Serum 5-methyltetrahydrofolate status is associated with one-carbon metabolism-related metabolite concentrations and enzyme activity indicators in young women, Int. J. Mol. Sci., 2023, vol. 24, no. 13, p. 10993. https://doi.org/10.3390/ijms241310993
Article CAS PubMed Google Scholar
Carr, B.I. and Guerra, V., Serum albumin levels in relation to tumor parameters in hepatocellular carcinoma patients, Int. J. Biol. Markers, 2017, vol. 32, no. 4, pp. e391–e396. https://doi.org/10.5301/ijbm.5000300
Lopez, J.B., Balasegaram, M., Thambyrajah, V., and Timor, J., The value of liver function tests in hepatocellular carcinoma, Malays. J. Pathol., 1996, vol. 18, no. 2, pp. 95–99.
Wang, X.P., Mao, M.J., He, Z.L., Zhang, L., Chi, P.D., Su, J.R., Dai, S.Q., and Liu, W.L., A retrospective discussion of the prognostic value of combining prothrombin time (PT) and fibrinogen (Fbg) in patients with hepatocellular carcinoma, J. Cancer, 2017, vol. 8, no. 11, pp. 2079–2087. https://doi.org/10.7150/jca.19181
Article CAS PubMed Google Scholar
Elgamal, S., Ghafar, A.A., Ghoneem, E., Elshaer, M., Alrefai, H., and Elemshaty, W., Characterization of patients with hepatocellular carcinoma on the way for early detection: One center experience, Egypt. J. Intern. Med., 2018, vol. 30, no. 4, pp. 231–238. https://doi.org/10.4103/ejim.ejim_29_18
Gao, H., Zhu, F., Wang, M., Zhang, H., Ye, D., Yang, J., Jiang, L., Liu, C., Qin, R., Yan, L., and Xiao, G., Preoperatively staging liver fibrosis using noninvasive method in hepatitis B virus-infected hepatocellular carcinoma patients, Oncotarget, 2017, vol. 8, no. 3, pp. 4289–4300. https://doi.org/10.18632/oncotarget.14024
Malaguarnera, M., Catania, V.E., Borzì, A.M., Malaguarnera, S., Madeddu, R., Bertino, G., and Latteri, S., Blood homocysteine levels are increased in hepatocellular carcinoma patients with portal vein thrombosis. A single centre retrospective cohort study, Int. J. Surg. Open, 2018, vol. 15, pp. 60–65. https://doi.org/10.1016/j.ijso.2018.11.001
Bhanji, R.A., Ma, M., Bain, V.G., and Montano-Loza, A.J., Hyperhomocysteinemia is associated with severity of cirrhosis and negative impact after liver transplantation, Liver Int., 2016, vol. 36, no. 5, pp. 696–704. https://doi.org/10.1111/liv.12979
Article CAS PubMed Google Scholar
Malaguarnera, G., Catania, V.E., Bertino, G., Drago, F., Madeddu, R., Bonfiglio, C., and Malaguarnera, M., Serum folate deficiency in HCV related hepatocellular carcinoma, Sci. Rep., 2022, vol. 12, no. 1, p. 5025. https://doi.org/10.1038/s41598-022-09030-1
Article CAS PubMed Google Scholar
Brown, A.R., Alhallak, I., Simmen, R.C.M., Melnyk, S.B., Heard-Lipsmeyer, M.E., Montales, M.T.E., Habenicht, D., Van, T.T., and Simmen, F.A., Krüppel-like factor 9 (KLF9) suppresses hepatocellular carcinoma (HCC)-promoting oxidative stress and inflammation in mice fed high-fat diet, Cancers, 2022, vol. 14, no. 7, p. 1737. https://doi.org/10.3390/cancers14071737
Article CAS PubMed Google Scholar
Bertino, G., Malaguarnera, G., Frazzetto, E., Sciuto, A., Inserra, G., Zanghì, G.N., and Malaguarnera, M., Responsibility of hepatitis C virus in the development of hepatocellular carcinoma: From molecular alterations to possible solutions, World J. Hepatol., 2018, vol. 10, no. 6, p. 448. https://doi.org/10.4254/wjh.v10.i6.448
Malaguarnera, G., Gagliano, C., Giordano, M., Salomone, S., Vacante, M., Bucolo, C., Caraci, F., Reibaldi, M., Drago, F., Avitabile, T., and Motta, M., Homocysteine serum levels in diabetic patients with non proliferative, proliferative and without retinopathy, Biomed. Res. Int., 2014, vol. 2014, p. 191497.
Comments (0)