Ali FEM, Ibrahim IM, Ghogar OM, Abd-Alhameed EK, Althagafy HS, Hassanein EHM (2023) Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study. World J Gastroenterol 29:1026–1053. https://doi.org/10.3748/wjg.v29.i6.1026
Article CAS PubMed PubMed Central Google Scholar
Binkowski BF, Butler BL, Stecha PF, Eggers CT, Otto P, Zimmerman K, Vidugiris G, Wood MG, Encell LP, Fan F, Wood KV (2011) A luminescent biosensor with increased dynamic range for intracellular cAMP. ACS Chem Biol 6:1193–1197. https://doi.org/10.1021/cb200248h
Article CAS PubMed Google Scholar
Bolte S, Cordelieres FP (2006) A guided tour into subcellular colocalization analysis in light microscopy. J Microsc 224:213–232. https://doi.org/10.1111/j.1365-2818.2006.01706.x
Article CAS PubMed Google Scholar
Brown RDR, Veerman BEP, Oh J, Tate RJ, Torta F, Cunningham MR, Adams DR, Pyne S, Pyne NJ (2021) A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells. J Biol Chem 296:100674. https://doi.org/10.1016/j.jbc.2021.100674
Article CAS PubMed PubMed Central Google Scholar
Cardinale CJ, Liu Y, Kevadia A, Strong A, Watts VJ, Hakonarson H (2025) The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T-helper 2 phenotype and Class II antigen presentation. J Crohns Colitis 19:jjaf030. https://doi.org/10.1093/ecco-jcc/jjaf030
Article PubMed PubMed Central Google Scholar
Chen J, Jiang Y, Hou M, Liu C, Liu E, Zong Y, Wang X, Meng Z, Gu M, Su Y, Wang H, Fu J (2024) Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC. Gut 74:128–140. https://doi.org/10.1136/gutjnl-2024-332902
Article CAS PubMed PubMed Central Google Scholar
Cheng L, Su L, Tian X, Xia F, Zhao C, Yan W, Shao Z (2022) A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors. J Vis Exp doi. https://doi.org/10.3791/64054
Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ (2013) Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J Pharmacol Exp Ther 347:276–287. https://doi.org/10.1124/jpet.113.207449
Article CAS PubMed PubMed Central Google Scholar
Devasani K, Yao Y (2022) Expression and functions of adenylyl cyclases in the CNS. Fluids Barriers CNS 19:23. https://doi.org/10.1186/s12987-022-00322-2
Article CAS PubMed PubMed Central Google Scholar
Drexler Y, Molina J, Mitrofanova A, Fornoni A, Merscher S (2021) Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases. J Am Soc Nephrol 32:9–31. https://doi.org/10.1681/ASN.2020050697
Article CAS PubMed Google Scholar
Eden N, Gaunt E, Ong EMS, Sharif K, Selinger C (2025) The Role of Novel Small Molecule Drugs in the Management of Inflammatory Bowel Disease. Br J Hosp Med (Lond) 86:1–14. https://doi.org/10.12968/hmed.2024.0798
Gao Y, Luo Y, Ji G, Wu T (2024) Functional and pathological roles of adenylyl cyclases in various diseases. Int J Biol Macromol 281:136198. https://doi.org/10.1016/j.ijbiomac.2024.136198
Article CAS PubMed Google Scholar
Guo R, Liu T, Shasaltaneh MD, Wang X, Imani S, Wen Q (2022) Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy. Front Oncol 12:829212. https://doi.org/10.3389/fonc.2022.829212
Article CAS PubMed PubMed Central Google Scholar
Jiang LI, Collins J, Davis R, Lin KM, DeCamp D, Roach T, Hsueh R, Rebres RA, Ross EM, Taussig R, Fraser I, Sternweis PC (2007) Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway. J Biol Chem 282:10576–10584. https://doi.org/10.1074/jbc.M609695200
Article CAS PubMed PubMed Central Google Scholar
Jiang LI, Collins J, Davis R, Fraser ID, Sternweis PC (2008) Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII. J Biol Chem 283:23429–23439. https://doi.org/10.1074/jbc.M803281200
Article CAS PubMed PubMed Central Google Scholar
Jiang LI, Wang JE, Sternweis PC (2013) Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway. Mol Pharmacol 83:587–593. https://doi.org/10.1124/mol.112.082446
Article CAS PubMed Google Scholar
Liu Q, Tang Z, Qian Y, Wang C, Kong C, Li M, Geng X, Zhang Y, Cheng X, Ren C, Wang K, Bai L, Wang L, Jiang D, Wang S, Liu X, Xia P (2025) Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome. Nat Chem Biol 21:1283–1291. https://doi.org/10.1038/s41589-025-01919-y
Article CAS PubMed Google Scholar
Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J, Kennedy NA, Lamb CA, McCarthy S, Ahmad T, Edwards C, Serra EG, Hart A, Hawkey C, Mansfield JC, Mowat C, Newman WG, Nichols S, Pollard M, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson DC, Lee JC, Prescott NJ, Lees CW, Mathew CG, Parkes M, Barrett JC, Anderson CA (2017) Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. Nat Genet 49:186–192. https://doi.org/10.1038/ng.3761
Article CAS PubMed PubMed Central Google Scholar
Means CK, Miyamoto S, Chun J, Brown JH (2008) S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem 283:11954–11963. https://doi.org/10.1074/jbc.M707422200
Article CAS PubMed PubMed Central Google Scholar
Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B (2003) Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. J Biol Chem 278:4552–4560. https://doi.org/10.1074/jbc.M210386200
Article CAS PubMed Google Scholar
Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS (2022) Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiol Rev 102:815–857. https://doi.org/10.1152/physrev.00013.2021
Article CAS PubMed Google Scholar
Pizzoni A, Zhang X, Altschuler DL (2024) From membrane to nucleus: A three-wave hypothesis of cAMP signaling. J Biol Chem 300: 105497 https://doi.org/10.1016/j.jbc.2023.105497
Rachmilewitz D, Karmeli F, Selinger Z (1983) Increased colonic adenylate cyclase activity in active ulcerative colitis. Gastroenterology 85:12–16
Article CAS PubMed Google Scholar
Raker VK, Becker C, Steinbrink K (2016) The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases. Front Immunol 7:123. https://doi.org/10.3389/fimmu.2016.00123
Article CAS PubMed PubMed Central Google Scholar
Reeve M, Kanai M, Graham D, Karjalainen J, Luo S, Kolosov N, Adams C, Ritari J, Karczewski K, Kiiskinen T, Fuller Z, Mehtonen J, Kurki M, Khan Z, Partanen J, McCarthy M, Artomov M, Tuomi T, Pirinen M, Kero J, Xavier R, Daly M, Ripatti S, Gen F (2024) Autoimmune hypothyroidism GWAS reveals independent autoimmune and thyroid-specific contributions and an inverse relation with cancer risk. Res Sq rs 3:rs–4626646. https://doi.org/10.21203/rs.3.rs-4626646/v1
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M (2008) Cyclic AMP: master regulator of innate immune cell function. Am J Respir Cell Mol Biol 39:127–132. https://doi.org/10.1165/rcmb.2008-0091TR
Article CAS PubMed PubMed Central Google Scholar
Shao S, Zeng W, Zhang J, Ma L, Huang F, Jiang Z (2025) Decoding rheumatoid arthritis: Biomarker identification and immune profiling via bioinformatics and Mendelian randomization. Med (Baltim) 104:e43872. https://doi.org/10.1097/MD.0000000000043872
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