Bates TC, Maes H, Neale MC (2019) Umx: twin and path-based structural equation modeling in R. Twin Res Hum Genet 22:27–41. https://doi.org/10.1017/thg.2019.2
Boomsma D, Busjahn A, Peltonen L (2002) Classical twin studies and beyond. Nat Rev Genet 3:872–882. https://doi.org/10.1038/nrg932
Article CAS PubMed Google Scholar
Buzzetti E, Pinzani M, Tsochatzis EA (2016) The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism 65:1038–1048. https://doi.org/10.1016/j.metabol.2015.12.012
Article CAS PubMed Google Scholar
Carrel L, Willard HF (2005) X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434:400–404. https://doi.org/10.1038/nature03479
Article CAS PubMed Google Scholar
Caussy C, Aubin A, Loomba R (2021) The relationship between type 2 diabetes, NAFLD, and cardiovascular risk. Curr Diab Rep 21:15. https://doi.org/10.1007/s11892-021-01383-7
Article PubMed PubMed Central Google Scholar
Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K (2012) The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet 8:e1002709. https://doi.org/10.1371/journal.pgen.1002709
Article CAS PubMed PubMed Central Google Scholar
Choudhary NS, Duseja A (2021) Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Transl Gastroenterol Hepatol 6:2. https://doi.org/10.21037/tgh.2019.09.06
Article PubMed PubMed Central Google Scholar
Duan H, Ning F, Zhang D, Wang S, Zhang D, Tan Q, Tian X, Pang Z (2013) The Qingdao Twin Registry: a status update. Twin Res Hum Genet 16:79–85. https://doi.org/10.1017/thg.2012.113
Felson J (2014) What can we learn from twin studies? A comprehensive evaluation of the equal environments assumption. Soc Sci Res 43:184–199. https://doi.org/10.1016/j.ssresearch.2013.10.004
Ferraioli G, Soares Monteiro LB (2019) Ultrasound-based techniques for the diagnosis of liver steatosis. World J Gastroenterol 25:6053–6062. https://doi.org/10.3748/wjg.v25.i40.6053
Article PubMed PubMed Central Google Scholar
Kozlitina J, Smagris E, Stender S, Nordestgaard BG, Zhou HH, Tybjærg-Hansen A, Vogt TF, Hobbs HH, Cohen JC (2014) Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 46:352–356. https://doi.org/10.1038/ng.2901
Article CAS PubMed PubMed Central Google Scholar
Loomba R, Friedman SL, Shulman GI (2021) Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell 184:2537–2564. https://doi.org/10.1016/j.cell.2021.04.015
Article CAS PubMed PubMed Central Google Scholar
Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D (2015) Heritability of hepatic fibrosis and steatosis based on a prospective twin study. Gastroenterology 149:1784–1793. https://doi.org/10.1053/j.gastro.2015.08.011
Article PubMed PubMed Central Google Scholar
Mackay TF (2014) Epistasis and quantitative traits: using model organisms to study gene-gene interactions. Nat Rev Genet 15:22–33. https://doi.org/10.1038/nrg3627
Article CAS PubMed Google Scholar
Maes HH, Neale MC, Eaves LJ (1997) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27:325–351. https://doi.org/10.1023/a:1025635913927
Article CAS PubMed Google Scholar
Mandrekar P (2011) Epigenetic regulation in alcoholic liver disease. World J Gastroenterol 17:2456–2464. https://doi.org/10.3748/wjg.v17.i20.2456
Article CAS PubMed PubMed Central Google Scholar
Mauvais-Jarvis F (2015) Sex differences in metabolic homeostasis, diabetes, and obesity. Biol Sex Differ 6:14. https://doi.org/10.1186/s13293-015-0033-y
Article CAS PubMed PubMed Central Google Scholar
Meng, L., Gao, W. J., Cao, W. H., Lyu, J., Yu, C. Q., Wu, T., Wang, S. F., Pang, Z. C., Yu, M., Wang, H., Wu, X. P., Dong, Z., Wu, F., Jiang, G. H., Wang, X. J., Lu, L., Li, L. M., 2020. Heritability of alcohol intake among adult twins, calculate by the structural equation model. Zhonghua Liu Xing Bing Xue Za Zhi 41, 819-823. https://doi.org/10.3760/cma.j.cn112338-20200103-00007
Article CAS PubMed Google Scholar
Poulsen P, Vaag A, Kyvik K, Beck-Nielsen H (2001) Genetic versus environmental aetiology of the metabolic syndrome among male and female twins. Diabetologia 44:537–543. https://doi.org/10.1007/s001250051659
Article CAS PubMed Google Scholar
Rich NE, Oji S, Mufti AR, Browning JD, Parikh ND, Odewole M, Mayo H, Singal AG (2018) Racial and Ethnic Disparities in Nonalcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 16:198-210.e192. https://doi.org/10.1016/j.cgh.2017.09.041
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN (2023) A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol 79:1542–1556. https://doi.org/10.1016/j.jhep.2023.06.003
Article CAS PubMed Google Scholar
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC, Hobbs HH (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40:1461–1465. https://doi.org/10.1038/ng.257
Article CAS PubMed PubMed Central Google Scholar
Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, Shiehmorteza M, Yokoo T, Chavez A, Middleton MS, Sirlin CB (2009) Heritability of nonalcoholic fatty liver disease. Gastroenterology 136:1585–1592. https://doi.org/10.1053/j.gastro.2009.01.050
Article CAS PubMed PubMed Central Google Scholar
Simon TG, Roelstraete B, Hagström H, Sundström J, Ludvigsson JF (2022) Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort. Gut 71:1867–1875. https://doi.org/10.1136/gutjnl-2021-325724
Stols-Gonçalves D, Meijnikman AS, Tristão LS, Santos CLD, Denswil NP, Verheij J, Bernardo WM, Nieuwdorp M (2024) Metabolic dysfunction-associated steatotic liver disease and alcohol-associated liver disease: liver DNA methylation analysis-a systematic review. Cells. https://doi.org/10.3390/cells13221893
Article PubMed PubMed Central Google Scholar
Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A, Lappalainen T, Regev A, Ardlie KG, Hacohen N, MacArthur DG (2017) Landscape of X chromosome inactivation across human tissues. Nature 550:244–248. https://doi.org/10.1038/nature24265
Article PubMed PubMed Central Google Scholar
Wagenknecht LE, Scherzinger AL, Stamm ER, Hanley AJ, Norris JM, Chen YD, Bryer-Ash M, Haffner SM, Rotter JI (2009) Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort. Obes (Silver Spring) 17:1240–1246. https://doi.org/10.1038/oby.2009.4
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