Asif K, Memeo L, Palazzolo S, Frion-Herrera Y, Parisi S, Caligiuri I, Canzonieri V, Granchi C, Tuccinardi T, Rizzolio F (2021) STARD3: A Prospective Target for Cancer Therapy. Cancers (Basel) 13. https://doi.org/10.3390/cancers13184693
Bicknell KA, Brooks G (2008) Reprogramming the cell cycle machinery to treat cardiovascular disease. Curr Opin Pharmacol 8:193–201. https://doi.org/10.1016/j.coph.2007.12.015
Article CAS PubMed Google Scholar
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229–263. https://doi.org/10.3322/caac.21834
Cerezo M, Sollis E, Ji Y, Lewis E, Abid A, Bircan KO, Hall P, Hayhurst J, John S, Mosaku A, Ramachandran S, Foreman A, Ibrahim A, McLaughlin J, Pendlington Z, Stefancsik R, Lambert SA, McMahon A, Morales J, Keane T, Inouye M, Parkinson H, Harris LW (2025) The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity. Nucleic Acids Res 53:D998–D1005. https://doi.org/10.1093/nar/gkae1070
Article CAS PubMed PubMed Central Google Scholar
Chen J, Imanaka N, Chen J, Griffin JD (2010) Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer 102:351–360. https://doi.org/10.1038/sj.bjc.6605486
Article CAS PubMed Google Scholar
Cheng YJ, Nie XY, Ji CC, Lin XX, Liu LJ, Chen XM, Yao H, Wu SH (2017) Long-Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer. J Am Heart Assoc 6. https://doi.org/10.1161/JAHA.117.005633
Dai L, Li R, Hao Q, Bao Y, Hu L, Zhang Y, Kang H, Wu H, Ma X, Song Y (2023) Breast cancer is associated with coronary heart disease: a cross-sectional survey of NHANES 1999–2018. Front Cardiovasc Med 10:1274976. https://doi.org/10.3389/fcvm.2023.1274976
Article PubMed PubMed Central Google Scholar
Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen MB, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P (2013) Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 368:987–998. https://doi.org/10.1056/NEJMoa1209825
Article CAS PubMed Google Scholar
Dominguez-Brauer C, Thu KL, Mason JM, Blaser H, Bray MR, Mak TW (2015) Targeting Mitosis in Cancer: Emerging Strategies. Mol Cell 60:524–536. https://doi.org/10.1016/j.molcel.2015.11.006
Article CAS PubMed Google Scholar
Gao X, Zhang Y, Li T, Li J, Su Y, Wang H, Yan Z, Qin K (2023) Uncovering the molecular mechanisms of Fructus Choerospondiatis against coronary heart disease using network pharmacology analysis and experimental pharmacology. Anal Biochem 675:115214. https://doi.org/10.1016/j.ab.2023.115214
Article CAS PubMed Google Scholar
Guo F, Kuo YF, Shih YCT, Giordano SH, Berenson AB (2018) Trends in breast cancer mortality by stage at diagnosis among young women in the United States. Cancer 124:3500–3509. https://doi.org/10.1002/cncr.31638
Article PubMed PubMed Central Google Scholar
Harris MA, Savas P, Virassamy B, O’Malley MMR, Kay J, Mueller SN, Mackay LK, Salgado R, Loi S (2024) Towards targeting the breast cancer immune microenvironment. Nat Rev Cancer 24:554–577. https://doi.org/10.1038/s41568-024-00714-6
Article CAS PubMed Google Scholar
Hsieh CT, Lee WC, Chiang CJ, Wang CC, Hsu HY, Lin HJ, Yeh TL, Tsai MC, Jhuang JR, Hsiao BY, Chien KL (2024) The Risk of Cancer-Associated and Radiotherapy-Associated Cardiovascular Diseases among Patients with Breast Cancer. Clin Breast Cancer 24:131–141e133. https://doi.org/10.1016/j.clbc.2023.11.002
Jiang Y, Li Y, Huang Y (2025) Circulating cytokines levels and the risk of polycystic ovary syndrome: A Mendelian randomization analysis. Med (Baltim) 104e41359. https://doi.org/10.1097/MD.0000000000041359
Kurki MI, Karjalainen J, Palta P, Sipila TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, Lehisto AA, Kanai M, Mars N, Ramo J, Kiiskinen T, Heyne HO, Veerapen K, Rueger S, Lemmela S, Zhou W, Ruotsalainen S, Parn K, Hiekkalinna T, Koskelainen S, Paajanen T, Llorens V, Gracia-Tabuenca J, Siirtola H, Reis K, Elnahas AG, Sun B, Foley CN, Aalto-Setala K, Alasoo K, Arvas M, Auro K, Biswas S, Bizaki-Vallaskangas A, Carpen O, Chen CY, Dada OA, Ding Z, Ehm MG, Eklund K, Farkkila M, Finucane H, Ganna A, Ghazal A, Graham RR, Green EM, Hakanen A, Hautalahti M, Hedman AK, Hiltunen M, Hinttala R, Hovatta I, Hu X, Huertas-Vazquez A, Huilaja L, Hunkapiller J, Jacob H, Jensen JN, Joensuu H, John S, Julkunen V, Jung M, Junttila J, Kaarniranta K, Kahonen M, Kajanne R, Kallio L, Kalviainen R, Kaprio J, FinnGen, Kerimov N, Kettunen J, Kilpelainen E, Kilpi T, Klinger K, Kosma VM, Kuopio T, Kurra V, Laisk T, Laukkanen J, Lawless N, Liu A, Longerich S, Magi R, Makela J, Makitie A, Malarstig A, Mannermaa A, Maranville J, Matakidou A, Meretoja T et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613:508–518. https://doi.org/10.1038/s41586-022-05473-8
Article CAS PubMed PubMed Central Google Scholar
Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559. https://doi.org/10.1186/1471-2105-9-559
Article CAS PubMed PubMed Central Google Scholar
Lapillo M, Salis B, Palazzolo S, Poli G, Granchi C, Minutolo F, Rotondo R, Caligiuri I, Canzonieri V, Tuccinardi T, Rizzolio F (2019) First-of-its-kind STARD(3) Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent. ACS Med Chem Lett 10:475–480. https://doi.org/10.1021/acsmedchemlett.8b00509
Article CAS PubMed PubMed Central Google Scholar
Li X, Cao Y, Li M, Jin F (2018) Upregulation of HES1 Promotes Cell Proliferation and Invasion in Breast Cancer as a Prognosis Marker and Therapy Target via the AKT Pathway and EMT Process. J Cancer 9:757–766. https://doi.org/10.7150/jca.22319
Article CAS PubMed PubMed Central Google Scholar
Li X, Li Y, Du X, Wang X, Guan S, Cao Y, Jin F, Li F (2021) HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer. Int J Biol Sci 17:247–258. https://doi.org/10.7150/ijbs.53477
Article CAS PubMed PubMed Central Google Scholar
Li P, Zhang Z, Lv H, Sun P (2022) Inhibiting the expression of STARD3 induced apoptosis via the inactivation of PI3K/AKT/mTOR pathway on ER(+) breast cancer. Tissue Cell 79:101971. https://doi.org/10.1016/j.tice.2022.101971
Article CAS PubMed Google Scholar
Liu ZH, Dai XM, Du B (2015) Hes1: a key role in stemness, metastasis and multidrug resistance. Cancer Biol Ther 16:353–359. https://doi.org/10.1080/15384047.2015.1016662
Article CAS PubMed PubMed Central Google Scholar
Matsunaga H, Ito K, Akiyama M, Takahashi A, Koyama S, Nomura S, Ieki H, Ozaki K, Onouchi Y, Sakaue S, Suna S, Ogishima S, Yamamoto M, Hozawa A, Satoh M, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Tanaka K, Arisawa K, Ikezaki H, Takashima N, Naito M, Wakai K, Tanaka H, Sakata Y, Morita H, Sakata Y, Matsuda K, Murakami Y, Akazawa H, Kubo M, Kamatani Y, Komuro I (2020) Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease. Circ Genom Precis Med 13:e002670. https://doi.org/10.1161/CIRCGEN.119.002670
Article CAS PubMed Google Scholar
Menon G, Alkabban FM, Ferguson T (2025) Breast Cancer. StatPearls. Treasure Island (FL)
Mubarik S, Yu Y, Wang F, Malik SS, Liu X, Fawad M, Shi F, Yu C (2022) Epidemiological and sociodemographic transitions of female breast cancer incidence, death, case fatality and DALYs in 21 world regions and globally, from 1990 to 2017: An Age-Period-Cohort Analysis. J Adv Res 37:185–196. https://doi.org/10.1016/j.jare.2021.07.012
Ramin C, Schaeffer ML, Zheng Z, Connor AE, Hoffman-Bolton J, Lau B, Visvanathan K (2021) All-Cause and Cardiovascular Disease Mortality Among Breast Cancer Survivors in CLUE II, a Long-Standing Community-Based Cohort. J Natl Cancer Inst 113:137–145. https://doi.org/10.1093/jnci/djaa096
Article CAS PubMed PubMed Central Google Scholar
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, FinnGen, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y (2021) A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet 53:1415–1424. https://doi.org/10.1038/s41588-021-00931-x
Article CAS PubMed PubMed Central Google Scholar
Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ (2007) The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 8:239–245. https://doi.org/10.1038/ni1443
Comments (0)