Berndt SI, Vijai J, Benavente Y, Camp NJ, Nieters A, Wang Z et al (2022) Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. Leukemia 36(12):2835–2844

Article  PubMed  PubMed Central  Google Scholar 

Bosch X, Sanclemente-Ansó C, Escoda O, Monclús E, Franco-Vanegas J, Moreno P et al (2018) Time to diagnosis and associated costs of an outpatient vs inpatient setting in the diagnosis of lymphoma: a retrospective study of a large cohort of major lymphoma subtypes in Spain. BMC Cancer 18(1):276

Article  PubMed  PubMed Central  Google Scholar 

Cao Y, Wang X, Jin T, Tian Y, Dai C, Widarma C et al (2020) Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy. Signal Transduct Target Ther 5(1):250

Article  PubMed  PubMed Central  Google Scholar 

Carrillo-Bustamante P, Keşmir C, de Boer RJ (2016) The evolution of natural killer cell receptors. Immunogenetics 68(1):3–18

Article  PubMed  Google Scholar 

Chiu J, Ernst DM, Keating A (2018) Acquired natural killer cell dysfunction in the tumor microenvironment of classic hodgkin lymphoma. Front Immunol 9:267

Article  PubMed  PubMed Central  Google Scholar 

David S (2021) A current guide to candidate gene association studies. Trends Genet 37(12):1056–1059

Article  PubMed  Google Scholar 

de Leval L, Alizadeh AA, Bergsagel PL, Campo E, Davies A, Dogan A et al (2022) Genomic profiling for clinical decision making in lymphoid neoplasms. Blood 140(21):2193–2227

Article  PubMed  PubMed Central  Google Scholar 

Din L, Sheikh M, Kosaraju N, Smedby KE, Bernatsky S, Berndt SI et al (2019) Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes. Genet Epidemiol 43(7):844–863

Article  PubMed  PubMed Central  Google Scholar 

Duminuco A, Scarso S, Del Fabro V, Caruso LA, Stanzione G, Di Raimondo F et al (2025) Diffuse large B-cell lymphoma in the new era: prognostic tools for mapping risk. Ann Hematol 104(10):4897–4911

Article  PubMed  PubMed Central  Google Scholar 

Espinoza JL, Minami M (2018) Sensing bacterial-induced DNA damaging effects. Front Immunol 9:52

Article  PubMed  PubMed Central  Google Scholar 

Espinoza J, Takami A, Onizuka M, Sao H, Akiyama H, Miyamura K et al (2009) NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies. Haematologica 94(10):1427–34

Article  PubMed  PubMed Central  Google Scholar 

Espinoza JL, Nguyen VH, Ichimura H, Pham TT, Nguyen CH, Pham TV et al (2016) A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers. Sci Rep 6:39231

Article  PubMed  PubMed Central  Google Scholar 

Espinoza JL, Nguyen VH, Ichimura H, Pham TTT, Nguyen CH, Pham TV et al (2016) A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers. Sci Rep. https://doi.org/10.1038/srep39231

Article  PubMed  PubMed Central  Google Scholar 

Furue H, Matsuo K, Kumimoto H, Hiraki A, Suzuki T, Yatabe Y et al (2008a) Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. Carcinogenesis 29(2):316–320

Article  PubMed  Google Scholar 

Furue H, Kumimoto H, Matsuo K, Suzuki T, Hasegawa Y, Shinoda M et al (2008) Opposite impact of NKG2D genotype by lifestyle exposure to risk of aerodigestive tract cancer among Japanese. Int J Cancer 123(1):181–6

Article  PubMed  Google Scholar 

Garrido P, Almeida J, Romero JM, Cantón J, Sandberg Y, Bárcena P et al (2008) Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis. Hum Immunol 69(2):101–7

Article  PubMed  Google Scholar 

Ghabadzaadeh S, Shams A, Islami G, Zadeh SA (2013) Study of the frequency of NKG2D rs1049174 polymorphism in breast cancer: comparison with healthy individuals. J Shahid Sadoughi Univ Med Sci 21(3):291–299

Google Scholar 

Haik J, Nardini G, Goldman N, Galore-Haskel G, Harats M, Zilinsky I et al (2016) Increased serum NKG2D-ligands and downregulation of NKG2D in peripheral blood NK cells of patients with major burns. Oncotarget 7(3):2220–2228

Article  PubMed  Google Scholar 

Hayashi T, Imai K, Morishita Y, Hayashi I, Kusunoki Y, Nakachi K (2006) Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral blood lymphocytes and cancer immunosurveillance. Cancer Res 66(1):563–570

Article  PubMed  Google Scholar 

Hilton LK, Scott DW, Morin RD (2023) Biological heterogeneity in diffuse large B-cell lymphoma. Semin Hematol 60(5):267–276

Article  PubMed  Google Scholar 

Imai K, Hayashi T, Yamaoka M, Kajimura J, Yoshida K, Kusunoki Y et al (2012) Effects of NKG2D haplotypes on the cell-surface expression of NKG2D protein on natural killer and CD8 T cells of peripheral blood among atomic-bomb survivors. Hum Immunol 73(6):686–91

Article  PubMed  Google Scholar 

Jelenčić V, Lenartić M, Wensveen FM, Polić B (2017) NKG2D: a versatile player in the immune system. Immunol Lett. https://doi.org/10.1016/j.imlet.2017.04.006

Article  PubMed  Google Scholar 

J. L. Espinoza, Akiyoshi Takami, Katsuji Yoshioka, Katsuya Nakata, Tokiharu Sato, Yoshihito Kasahara, Shinji Nakao. Haematologica. 2012 Sep;97(9):1295–1303. https://doi.org/10.3324/haematol.2011.058529

Kuznetsova AV, Glukhova XA, Beletsky IP, Ivanov AA (2025) NK cell activity in the tumor microenvironment. Front Cell Dev Biol 13:1609479

Article  PubMed  PubMed Central  Google Scholar 

Lee K, Lee C (2023) Generation of CRISPR-Cas9-mediated knockin mutant models in mice and MEFs for studies of polymorphism in clock genes. Sci Rep 13(1):8109

Article  PubMed  PubMed Central  Google Scholar 

Lee J, Lee K, Kim D, Heo D (2004) Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. J Immunol 172(12):7335–7340

Article  PubMed  Google Scholar 

Lin Z, Assaraf YG, Kwok HF (2024) Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies. Cancer Metastasis Rev 43(4):1315–1336

Article  PubMed  Google Scholar 

Molfetta R, Quatrini L, Santoni A, Paolini R (2017) Regulation of NKG2D-dependent NK cell functions: the yin and the yang of receptor endocytosis. Int J Mol Sci. https://doi.org/10.3390/ijms18081677

Article  PubMed  PubMed Central  Google Scholar 

Moore A, Kane E, Wang Z, Panagiotou OA, Teras LR, Monnereau A et al (2019) Genetically determined height and risk of Non-hodgkin lymphoma. Front Oncol 9:1539

Article  PubMed  Google Scholar 

Muntasell A, Ochoa MC, Cordeiro L, Berraondo P, de López-Díaz Cerio A, Cabo M et al (2017) Targeting NK-cell checkpoints for cancer immunotherapy. Curr Opin Immunol 45:73–81

Article  PubMed  Google Scholar 

Patil S, Rajput S, Mhaiskar A (2025) B-cell lymphoma: advances in pathogenesis, diagnosis, and targeted therapies. Pathol Res Pract 271:156036

Article  PubMed  Google Scholar 

Shafi S, Vantourout P, Wallace G, Antoun A, Vaughan R, Stanford M et al (2011) An NKG2D-mediated human lymphoid stress surveillance response with high interindividual variation. Sci Transl Med 3(113):113ra24

Article  Google Scholar 

Shen Z, Tan Z, Ge L, Wang Y, Xing X, Sang W et al (2024) The global burden of lymphoma: estimates from the global burden of disease 2019 study. Public Health 226:199–206

Article  PubMed  Google Scholar 

VH JLE, TT NHI, CH P (2016) N, TV P, A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to human papilloma Virus-related cancers. Sci Rep

Viet NH, Trung NQ, Dong LT, Trung LQ, Espinoza JL (2021) Genetic variants in NKG2D axis and susceptibility to Epstein-Barr virus-induced nasopharyngeal carcinoma. J Cancer Res Clin Oncol 147(3):713–723

Article  PubMed  PubMed Central