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Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates
Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates
Non-human primates are important for preclinical vaccine evaluation. In depth characterization of the antibody response re...
Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease?
Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease?
The major histocompatibility complex (MHC) plays a central role in immune responses, with strong links to both infectious ...
NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis
NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis
Lymphomas are biologically heterogeneous malignancies with multifactorial etiologies involving genetic, environmental, and...
Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissues
Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissues
Within the bovine immune response, a distinct type of immunoglobulin (Ig), known as ultralong complementarity-determining ...
Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19
Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19
Integrating whole-genome sequencing with single-cell RNA-seq data enhances the current understanding of how genomic differ...
Evolution of and reveals complex duplication scenarios in Muroids and Ruminants
Evolution of and reveals complex duplication scenarios in Muroids and Ruminants
Chemokine receptor type 1 (CCR1) is expressed on several immune cells, including neutrophils, monocytes, and T cells. In r...
The digital keystone: how artificial intelligence is reshaping HLA research and clinical practice
The digital keystone: how artificial intelligence is reshaping HLA research and clinical practice
The human leukocyte antigen (HLA) system underpins allorecognition and shapes the response to infection, autoimmunity, and...
Genetic and evolutionary characteristics of the major histocompatibility complex class II β-chain genes of a large colony of captive king penguins ()
Genetic and evolutionary characteristics of the major histocompatibility complex class II β-chain genes of a large colony of captive king penguins ()
Major histocompatibility complex class II beta (MHC-class IIB) genes are highly polymorphic and play important roles in im...
Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification
Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification
The humoral immune response relies on a diverse antibody repertoire, which is expanded through processes such as somatic h...
Genetic and immunological determinants of Pemphigus vulgaris: integrative analysis of HLA-DRB1 and FCGR2B variants
Genetic and immunological determinants of Pemphigus vulgaris: integrative analysis of HLA-DRB1 and FCGR2B variants
Pemphigus vulgaris (PV) is a rare autoimmune blistering disease mediated by pathogenic autoantibodies. Although both HLA a...
Allelic diversity and selection at the MHC class I and class II in a long-distance migratory shorebird, the Hudsonian Godwit ()
Allelic diversity and selection at the MHC class I and class II in a long-distance migratory shorebird, the Hudsonian Godwit ()
The major histocompatibility complex (MHC) plays a central role in vertebrate adaptive immunity by encoding receptors that...
Deciphering in Avians: unravelling loss events and functional insights
Deciphering in Avians: unravelling loss events and functional insights
In vertebrates, cytidine-to-uracil (C-to-U) editing is mediated by the AID/APOBEC family of deaminases, with APOBEC1 (A1) ...
Climate factors and selection shape MHC class II diversity in a montane wild sheep ()
Climate factors and selection shape MHC class II diversity in a montane wild sheep ()
Understanding how environmental heterogeneity drives spatially varying selection is key to deciphering adaptive evolution....
Reconstructed amphibian heavy-chain constant regions support a mosaic origin of IgXA with IgY-like CH1–CH2, an intermediate CH3, and an IgM-like CH4
Reconstructed amphibian heavy-chain constant regions support a mosaic origin of IgXA with IgY-like CH1–CH2, an intermediate CH3, and an IgM-like CH4
The evolutionary relationship between amphibian IgM, IgY, and IgX/A-like antibodies has remained difficult to resolve, lar...
Genetic characterization of the and its allelic association with in the chicken major histocompatibility complex
Genetic characterization of the and its allelic association with in the chicken major histocompatibility complex
TAPBP is a key chaperone of the peptide-loading complex that facilitates peptide loading onto major histocompatibility com...
Unraveling the genomic structures, conserved functional domains and evolutionary dynamics of beta-defensins in and
Unraveling the genomic structures, conserved functional domains and evolutionary dynamics of beta-defensins in and
Defensins are key innate immune proteins exhibiting pleiotropic functions such as antibacterial activity, antiviral activi...
Elevated interleukin-36γ and gene polymorphisms implicate novel risk in essential hypertension
Elevated interleukin-36γ and gene polymorphisms implicate novel risk in essential hypertension
Cytokines are crucial in regulating hypertension and vascular inflammation. The clinical significance of circulating IL-36...
Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis
Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis
Breast cancer (BC) is closely linked to coronary heart disease (CHD), yet the genetic causal relationship and common drivi...
HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand
HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand
The Maniq, a small and isolated nomadic hunter-gatherer population from the rainforests of Southern Thailand, offer a uniq...
Genetic diversity of in Latin American Creole cattle: an update of the state of the art
Genetic diversity of in Latin American Creole cattle: an update of the state of the art
Genetic diversity of the bovine leukocyte antigen BoLA-DRB3 gene has been reported in cattle breeds due to its central rol...
Association between single-nucleotide polymorphism rs868875 of gene and clinical severity of COVID-19 in a Brazilian population
Association between single-nucleotide polymorphism rs868875 of gene and clinical severity of COVID-19 in a Brazilian population
COVID-19, caused by the SARS-CoV-2 virus, has had a global impact, leading to high incidence and mortality rates worldwide...
Immunoglobulin genetics of a model squamate reptile,
Immunoglobulin genetics of a model squamate reptile,
Squamate reptiles are a diverse group of terrestrial vertebrates that includes over 10,000 species. Despite their broad di...
Genetic insights into the major histocompatibility complex class I BF2 gene of Korean native chickens in relation to the LEI0258 microsatellite marker and the 90-SNP panel
Genetic insights into the major histocompatibility complex class I BF2 gene of Korean native chickens in relation to the LEI0258 microsatellite marker and the 90-SNP panel
The chicken major histocompatibility complex (MHC) represents a “minimal essential MHC” consisting of classica...
Evaluation of lymphoid defects in specific inborn errors of immunity using a single-tube multicolor flow cytometry assay
Evaluation of lymphoid defects in specific inborn errors of immunity using a single-tube multicolor flow cytometry assay
The present study aimed to evaluate lymphoid defects in patients with specific IEIs (n = 28) using a 12-antibo...
Compact genomic architecture of the axolotl MHC region: setting the record straight
Compact genomic architecture of the axolotl MHC region: setting the record straight
The Major Histocompatibility Complex (MHC) is a gene-dense genomic region essential to adaptive immunity, exhibiting both ...
Evolution of SAMD9 and SAMD9L genes in primates: a complex history of gene loss, gene duplication and pseudogenization
Evolution of SAMD9 and SAMD9L genes in primates: a complex history of gene loss, gene duplication and pseudogenization
The Sterile Alpha Motif Domain-containing 9 (SAMD9) and SAMD9-like (SAMD9L) are two paralogous genes responsible for impor...
A novel mutation in associated with a syndromic immunodeficiency and cardiomyopathy
A novel mutation in associated with a syndromic immunodeficiency and cardiomyopathy
Genetic variants in Folliculin interacting protein 1 (FNIP1) were recently discovered as monogenic causes for immunodefici...
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
The blockade of the interleukin 6 receptor (IL-6R) demonstrates significant potential in various autoimmune diseases (ADs)...
Spatial variation in toll-like receptor diversity in koala populations across their geographic distribution
Spatial variation in toll-like receptor diversity in koala populations across their geographic distribution
The koala (Phascolarctos cinereus) is an iconic Australian species that is listed as endangered in the northern parts of i...
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Lept...
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