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Single-cell and spatial transcriptomics identify CAPG as a key driver of cisplatin resistance in bladder cancer
Single-cell and spatial transcriptomics identify CAPG as a key driver of cisplatin resistance in bladder cancer
Cisplatin-based chemotherapy is widely used for bladder cancer, yet therapeutic resistance remains a major clinical obstac...
Multi-omics identification of SPON1-related risk model for predicting prognosis and drug response in ovarian cancer
Multi-omics identification of SPON1-related risk model for predicting prognosis and drug response in ovarian cancer
Ovarian cancer (OC) is a highly lethal gynecological malignancy owing to late-stage diagnosis, high recurrence and metasta...
ANGPTL4 in gestational diabetes: a diagnostic biomarker linked to placental senescence
ANGPTL4 in gestational diabetes: a diagnostic biomarker linked to placental senescence
Current diagnostic methods for Gestational Diabetes Mellitus (GDM) inadequately reflect early placental pathophysiology. A...
Correction to: Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer
Correction to: Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Systems-level genomic analyses reveal shared mechanisms underlying endometriosis and sleep disorders
Systems-level genomic analyses reveal shared mechanisms underlying endometriosis and sleep disorders
We examined clinical, genetic, and molecular links between sleep disorders and endometriosis. Women aged 20–54&n...
Single-cell and spatial transcriptomic landscapes reveal PIGT as a pivotal regulator of immunometabolic remodeling in colorectal cancer liver metastasis
Single-cell and spatial transcriptomic landscapes reveal PIGT as a pivotal regulator of immunometabolic remodeling in colorectal cancer liver metastasis
Colorectal cancer liver metastasis (CRLM) represents the leading cause of mortality in colorectal cancer (CRC). However, t...
A review of ARGOS-mediated regulation of plant organ size: molecular mechanisms, environmental interactions, and agricultural implications
A review of ARGOS-mediated regulation of plant organ size: molecular mechanisms, environmental interactions, and agricultural implications
Improving crop productivity relies on a thorough comprehension of genetic modules that coordinate plant organ growth with ...
USF1-mediated transcription of PARP1 contributes to sevoflurane-induced pyroptosis in perioperative neurocognitive disorders
USF1-mediated transcription of PARP1 contributes to sevoflurane-induced pyroptosis in perioperative neurocognitive disorders
Perioperative neurocognitive disorders (POCD) are a class of common complications of central nervous system after general ...
Dihydrolipoamide dehydrogenase promotes hepatocellular carcinoma progression and modulates cuproptosis-dependent cell death
Dihydrolipoamide dehydrogenase promotes hepatocellular carcinoma progression and modulates cuproptosis-dependent cell death
Hepatocellular carcinoma (HCC) is a major cause of cancer deaths with few treatment options. Cuproptosis, a copper-depende...
Hsa_circ_0006969 aggravates keratinocytes from high-glucose injury by sponging miR-375 to promote USP10 and SCD expression
Hsa_circ_0006969 aggravates keratinocytes from high-glucose injury by sponging miR-375 to promote USP10 and SCD expression
Diabetic foot ulcer (DFU) is a severe and frequent complication of diabetes, posing a major burden on patient well-being. ...
A single-cell cell-of-origin audit of the lncRNA RMST: bulk expression under-represents its broad neural expression and over-attributes a liver biomarker
A single-cell cell-of-origin audit of the lncRNA RMST: bulk expression under-represents its broad neural expression and over-attributes a liver biomarker
Long non-coding RNAs (lncRNAs) are widely nominated as biomarkers from bulk-tissue data, which cannot reveal which cell ty...
LGMN regulates endothelial-to-mesenchymal transition via the p38 MAPK pathway to promote pulmonary fibrosis
LGMN regulates endothelial-to-mesenchymal transition via the p38 MAPK pathway to promote pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease driven by fibroblast activation and extracellular...
Identification of the BCO gene family and its effect on body coloration in
Identification of the BCO gene family and its effect on body coloration in
The beta-carotene oxygenase (BCO) gene family plays a key role in carotenoid metabolism, which is closely linked to body c...
Exposure-informed lung transcriptomic analysis links predicted NNK targets to cell type-specific remodeling programs in idiopathic pulmonary fibrosis
Exposure-informed lung transcriptomic analysis links predicted NNK targets to cell type-specific remodeling programs in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is associated with cigarette smoking, yet the relationship between the tobacco-specifi...
Single-cell immune landscape of patients with different ovarian reserves during COH
Single-cell immune landscape of patients with different ovarian reserves during COH
Assisted reproductive technology (ART) is widely used to treat infertility, a global health burden. Controlled ovarian hyp...
Developmental dynamics of ovine lung in health and cystic fibrosis at single-cell resolution
Developmental dynamics of ovine lung in health and cystic fibrosis at single-cell resolution
The sheep lung has long been used to model aspects of the human lung, both its normal development and pathological changes...
Dual-reference projection defines a callable core and reference-sensitive shell in a Qiantang River draft assembly
Dual-reference projection defines a callable core and reference-sensitive shell in a Qiantang River draft assembly
Short-read genome projects in non-model fishes are often interpreted in chromosome-scale coordinates before assemblies can...
Cross-species functional transcriptomic analysis distinguishes conserved aging-niche remodeling from inflammatory fibroblast heterogeneity in cardiac aging and heart failure
Cross-species functional transcriptomic analysis distinguishes conserved aging-niche remodeling from inflammatory fibroblast heterogeneity in cardiac aging and heart failure
Cardiac aging is accompanied by inflammatory and extracellular-matrix remodeling, but the extent to which aging-associated...
Whole genome sequencing and annotation of a non-pathogenic TZ1MST22 strain isolated from in Southern Tunisian oases
Whole genome sequencing and annotation of a non-pathogenic TZ1MST22 strain isolated from in Southern Tunisian oases
Fusarium sambucinum species complex (FSAMSC) includes not only major mycotoxin-producing pathogens but also non-pathogenic...
IFI6 is associated with interferon activation and complement-associated immune responses in primary Sjögren’s disease
IFI6 is associated with interferon activation and complement-associated immune responses in primary Sjögren’s disease
Primary Sjögren’s disease (pSjD) is a systemic autoimmune disease characterized by chronic immune-mediated infl...
Can the molecular and transgenic breeding of crops be an alternative and sustainable technology to meet food demand?
Can the molecular and transgenic breeding of crops be an alternative and sustainable technology to meet food demand?
The gradual increase in the worldwide population represents various challenges, and one of the most alarming being the foo...
Roles of Immunity and Endogenous Retroelements in the Pathogenesis of Rheumatoid Arthritis and Treatment Strategies
Roles of Immunity and Endogenous Retroelements in the Pathogenesis of Rheumatoid Arthritis and Treatment Strategies
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease that primarily affects the joints. RA usually res...
Epigenetic profiles integrated with transcriptomic reveal the difference between COPD and PRISm in KOCOSS-NIH
Epigenetic profiles integrated with transcriptomic reveal the difference between COPD and PRISm in KOCOSS-NIH
In 2023, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) introduced a provision regarding preserved rati...
EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis
EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis
Human EXO1 is a 5' → 3' exonuclease that plays a critical role in regulating cell cycle checkpoi...
Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations
Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations
Cancer diagnostics highlight the critical requirement for sensitive and accurate tools with functional biomarkers for earl...
Multi-omic profiling identifies as a predictor of immune infiltration and prognosis in gastroesophageal junction cancer
Multi-omic profiling identifies as a predictor of immune infiltration and prognosis in gastroesophageal junction cancer
Gastroesophageal junction cancer (GEJ) is typically investigated alongside gastric or esophageal cancers. However, separat...
Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks
Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks
Acute pancreatitis (AP) is a common gastrointestinal inflammatory disease that requires hospitalization, with 40–70%...
Identification of a NEK7-related pyroptosis gene signature against pancreatic cancer and evaluation of its potential in tumor microenvironment remodeling via regulating inflammasome complex
Identification of a NEK7-related pyroptosis gene signature against pancreatic cancer and evaluation of its potential in tumor microenvironment remodeling via regulating inflammasome complex
The treatment options for pancreatic ductal adenocarcinoma (PDAC) remain limited. It is therefore important to explore new...
A Multi-omics approach to identify and validate shared genetic architecture in rheumatoid arthritis, multiple sclerosis, and type 1 diabetes: integrating GWAS, GEO, MSigDB, and scRNA-seq data
A Multi-omics approach to identify and validate shared genetic architecture in rheumatoid arthritis, multiple sclerosis, and type 1 diabetes: integrating GWAS, GEO, MSigDB, and scRNA-seq data
The notable comorbidity among autoimmune diseases underscores their shared genetic underpinnings, particularly evident in ...
SNP’s use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic
SNP’s use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic
Breast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, necessitating ongoing researc...
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